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Systemic Effects

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Photodynamic Therapy in Veterinary Medicine: From Basics to Clinical Practice

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Abstract

Photodynamic therapy (PDT) is a clinically approved practice for treatment of cancer and infectious diseases. PDT involves systemic or topical administration of a photosensitizer (PS), followed by irradiation of the target area with light of a wavelength matching the absorption band of the PS. In the presence of oxygen, photochemical reactions trigger the production of reactive oxygen species and, consequently, cell death by oxidative stress. Besides causing direct cytotoxicity to tumor cells, PDT induces destruction of the tumor vasculature releasing pro-inflammatory cytokines. Current literature supports that PDT is able to affect both the innate and adaptive responses of the immune system. In addition, PDT-induced adaptive immunity may attack distant untreated tumor cells and lead to development of antitumor memory immunity, which can potentially avoid the cancer relapse. Conversely, pro-inflammatory activity of PDT can also collaborate to resolve local infections since more neutrophils are recruited to the infected region.

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Acknowledgments

MR Hamblin was supported by the US NIH Grant R01AI050875.

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Authors and Affiliations

  1. Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, Bartlett Hall, Room 414, Boston, MA, USA

    Michael Richard Hamblin

  2. Department of Dermatology, Harvard Medical School, Boston, MA, USA

    Michael Richard Hamblin

  3. Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA

    Michael Richard Hamblin

  4. Department of Microbiology, Institute for Biomedical Sciences, University of São Paulo, Av. Lineu Prestes 1347, Cidade Universitária, Sao Paulo, 05508-000, SP, Brazil

    Caetano Padial Sabino

  5. Department of Clinical Analysis, School of Pharmaceutical Sciences, University of São Paulo, Sao Paulo, Brazil

    Caetano Padial Sabino

  6. Center for Lasers and Applications, Nuclear and Energy Research Institute, National Commission for Nuclear Energy, Sao Paulo, SP, Brazil

    Caetano Padial Sabino

  7. Department of Medical Biophysics, Princess Margaret Cancer Institute, University of Toronto, Toronto, Canada

    Caetano Padial Sabino

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  1. Michael Richard Hamblin
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Correspondence to Michael Richard Hamblin .

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Editors and Affiliations

  1. University of São Paulo, Department of Internal Medicine, School of Veterinary Medicine and Animal Science, Butantã, São Paulo, Brazil

    Fábio Parra Sellera

  2. Santos Aquarium, Veterinary Unit of Santos Aquarium, Ponta da Praia, Santos, São Paulo, Brazil

    Cristiane Lassálvia Nascimento

  3. IPEN-CNEN/SP, Center for Lasers and Applications, Cidade Universitária, São Paulo, São Paulo, Brazil

    Martha Simões Ribeiro

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Hamblin, M.R., Sabino, C.P. (2016). Systemic Effects. In: Sellera, F., Nascimento, C., Ribeiro, M. (eds) Photodynamic Therapy in Veterinary Medicine: From Basics to Clinical Practice. Springer, Cham. https://doi.org/10.1007/978-3-319-45007-0_6

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