Abstract
Resected brain metastases have a high rate of local recurrence without adjuvant therapy. Adjuvant whole-brain radiotherapy (WBRT) remains the standard of care with a local control rate >90 %. However, WBRT is delivered over 10–15 days, which can delay other therapy and is associated with acute and long-term toxicities. Permanent brachytherapy implants can be used at the time of surgical resection, which both provides necessary adjuvant therapy as well as allowing the patient’s disease to be treated fully in one visit. Several radioisotopes have been used in central nervous system brachytherapy, including low dose rate Iodine-125 and Cesium-131. Cesium-131 in particular provides an excellent balance between optimizing local control and minimizing toxicities associated with radiation treatment.
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Wernicke, A.G., Taube, S., Smith, A.W., Parashar, B. (2017). Central Nervous System Brachytherapy. In: Mayadev, J., Benedict, S., Kamrava, M. (eds) Handbook of Image-Guided Brachytherapy. Springer, Cham. https://doi.org/10.1007/978-3-319-44827-5_18
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DOI: https://doi.org/10.1007/978-3-319-44827-5_18
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