Fundamentals on Osteochondral Tissue Engineering

  • Viviana RibeiroEmail author
  • Sandra Pina
  • Joaquim Miguel Oliveira
  • Rui Luís Reis
Part of the Studies in Mechanobiology, Tissue Engineering and Biomaterials book series (SMTEB, volume 21)


The repair and regeneration of osteochondral (OC) defects has been increasing owing the high number of diseases, trauma and injuries. Although current clinical options are effective for the treatment of the OC lesions, new therapeutic options are necessary for the complete regeneration of the damaged articular cartilage which has a limited healing capacity. OC tissue engineering has been proposing advanced tools and technologies involving structured scaffolds, bioactive molecules, and cells for the repair and regeneration of the bone and cartilage tissues, as well as their interface. Multi-phased or stratified scaffolds with distinct bone and cartilage sections have been designed for OC repair. Diverse forms, as porous scaffolds, fibres, and hydrogels are the most commonly strategies used for OC tissue engineering. This chapter presents the current treatment and biomimetic strategies for OC tissue engineering. Structure and properties of the OC tissue are also briefly described.


Articular Cartilage Subchondral Bone Collagen Fibril Composite Scaffold Amorphous Calcium Phosphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The research leading to this work has received funding from the European Union’s Seventh Framework Program (FP7/2007-2013) under grant Agreement No REGPOT-CT2012-316331-POLARIS, and from QREN (ON.2—NORTE-01-0124-FEDER-000016) cofinanced by North Portugal Regional Operational Program (ON.2—O Novo Norte), under the National Strategic Reference Framework (NSRF), through the European Regional Development Fund (ERDF). Thanks are also due to the Portuguese Foundation for Science and Technology (FCT) and FSE/POCH (Fundo Social Europeu através do Programa Operacional do Capital Humano), PD/59/2013, for the project PEst-C/SAU/LA0026/201, for the fellowship grants of Sandra Pina (SFRH/BPD/108763/2015) and Viviana Ribeiro (PD/BD/113806/2015), and for the distinction attributed to J.M. Oliveira under the Investigator FCT program (IF/00423/2012).


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Viviana Ribeiro
    • 1
    • 2
    Email author
  • Sandra Pina
    • 1
    • 2
  • Joaquim Miguel Oliveira
    • 1
    • 2
  • Rui Luís Reis
    • 1
    • 2
  1. 1.3B’s Research Group—Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoBarco, GuimarãesPortugal
  2. 2.ICVS/3B’s—PT Government Associate LaboratoryBraga, GuimarãesPortugal

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