Advances in Biomaterials for the Treatment of Articular Cartilage Defects

  • Cristiana GonçalvesEmail author
  • Hajer Radhouani
  • Joaquim Miguel Oliveira
  • Rui Luís Reis
Part of the Studies in Mechanobiology, Tissue Engineering and Biomaterials book series (SMTEB, volume 21)


The management of cartilage defects is one of the most challenging problems for public and medical communities. The complete repairing of the damaged cartilage is a complex procedure, since articular cartilage is characterized by a poor vascularization (absence of blood vessels and nerve source), which limits the capacity to repair itself. Cartilage tissue engineering and regenerative medicine are relatively novel areas of research and may hold the key to the successful treatment of cartilage diseases and disorders. Materials such as natural and synthetic biomaterials have been explored to recreate the microarchitecture of articular cartilage through multilayered biomimetic scaffolds. In this chapter, an overview is given of the natural and synthetic biomaterials used on cartilage repair, describing the procedures to obtain these biomaterials, their chemical structure, their modifications to enhance their properties, and also their medical applications.


Articular Cartilage Hyaluronic Acid Atom Transfer Radical Polymerization Atom Transfer Radical Polymerization Chondroitin Sulphate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Cristiana Gonçalves
    • 1
    • 2
    Email author
  • Hajer Radhouani
    • 1
    • 2
  • Joaquim Miguel Oliveira
    • 1
    • 2
  • Rui Luís Reis
    • 1
    • 2
  1. 1.3B’s Research Group—Biomaterials, Biodegradables and Biomimetics, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoBarco, GuimarãesPortugal
  2. 2.ICVS/3B’s—PT Government Associate LaboratoryBraga, GuimarãesPortugal

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