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Influences of Germline Cells on Organismal Lifespan and Healthspan

  • Francis R. G. Amrit
  • Arjumand GhaziEmail author
Chapter
Part of the Healthy Ageing and Longevity book series (HAL)

Abstract

Historically, research has focused on the detrimental effects of ageing on fertility, but studies in the last two decades have shown that reproductive status profoundly impacts the length and quality of life. The nematode C. elegans has been at the forefront of these discoveries that have led to a fundamental transformation in our understanding of the relationship between procreation and lifespan in metazoans. In C. elegans, removing a population of proliferative germline-stem cells (GSCs) confers long life and enhances stress resilience. Germline loss is a major physiological challenge that compels the animal to arrest reproduction and reorganize its metabolic profile, so the phenomenon also provides a unique platform to understand how complex metazoans cope with changes in fertility and age. Recent studies have shown that GSC depletion triggers the activation of a group of conserved transcription factors in somatic cells. The transcriptional changes orchestrated by these proteins alter lipid metabolism, proteasomal function, autophagy and stress resistance, events that likely facilitate the adaptation to germline loss and lead to improved health and longevity. Here, we review the current literature on this longevity paradigm and the contributions made by C. elegans to understanding the molecular basis of the reproductive control of ageing.

Keywords

Ageing Reproduction Germline Lipid metabolism glp-1 Longevity Transcription Factor Autophagy Proteostasis 

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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Department of Paediatrics, Rangos Research CentreUniversity of PittsburghPittsburghUSA

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