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Patent Ductus Arteriosus

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Congenital Heart Disease in Pediatric and Adult Patients

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Abstract

Patent ductus arteriosus accounts for 5–10 % of all congenital heart diseases with an incidence of 1 in 2,000 live births in children born at term. The failure of ductus arteriosus closure results in a left-to-right shunt that can lead to pulmonary vascular and left ventricular volume overload. Necrotizing enterocolitis, myocardial dysfunction, systemic hypotension, altered intracerebral blood flow, and intracerebral and intraventricular hemorrhage have been associated with failed ductal constriction. Transthoracic echocardiography remains the gold standard method for patent ductus arteriosus diagnosing. Therapy options designed to close a patent ductus arteriosus in premature infants remain challenging. Previously, medical therapy with indomethacin or surgical ligation constituted the only two options for symptomatic patent ductus arteriosus. Nowadays, the use of paracetamol and the advent of smaller occlusion devices and transcatheter therapy have gained importance as alternative treatments of hemodynamically significant patent ductus arteriosus, with reports of even treating patients <1 kg.

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Author information

Authors and Affiliations

  1. Fellowship of Advanced Aortic Surgery, Ospedale San Raffaele, Milan, Italy

    Sthefano Atique Gabriel MD, PhD (Vascular and Endovascular Surgeon)

  2. São José do Rio Preto, São Paulo, Brazil

    Edmo Atique Gabriel MD, PhD (Cardiac Surgeon, Coordinator and Professor of Medicine of União das Faculdades dos Grandes Lagos (Unilago)

Authors
  1. Sthefano Atique Gabriel MD, PhD
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  2. Edmo Atique Gabriel MD, PhD
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Corresponding author

Correspondence to Sthefano Atique Gabriel MD, PhD .

Editor information

Editors and Affiliations

  1. Cardiac Anesthesiology Department, Anesthesiology Research Center Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Ali Dabbagh

  2. Kaiser Permanente Los Angeles Medical Center Division of Cardiac Anesthesiology, Los Angeles, California, USA

    Antonio Hernandez Conte

  3. Department of Anesthesiology, Cedars-Sinai Medical Center, Los Angeles, California, USA

    Lorraine Lubin

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Gabriel, S.A., Gabriel, E.A. (2017). Patent Ductus Arteriosus. In: Dabbagh, A., Conte, A., Lubin, L. (eds) Congenital Heart Disease in Pediatric and Adult Patients. Springer, Cham. https://doi.org/10.1007/978-3-319-44691-2_25

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  • DOI: https://doi.org/10.1007/978-3-319-44691-2_25

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-44689-9

  • Online ISBN: 978-3-319-44691-2

  • eBook Packages: MedicineMedicine (R0)

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