Abstract
Scar resulting from umbilical reconstruction or reimplantation is treated by physical or chemical methods. The authors describe the healing process, abnormal healing such as hypertrophic and keloid scar, and therapeutic options. The treatment of abnormal scarring with triamcinolone and 5-FU is discussed. The authors’ experience with 5 FU solution (5 FU, triamcinolone) has histopathologically demonstrated the effectiveness of collagen fiber synthesis reduction and fiber rearrangement, thus explaining the positive clinical effect
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References
Fitzpatrick RE. Treatment of inflamed hypertrophic scars using intralesional 5-FU. Dermatol Surg. 1999;25(3):224–32.
Blugerman G. Keloids and Hypertrophic scars. Congreso de CirugĂa Plástica del Cono Sur, Porto Alegre. Brasil: Mayo; 2001.
Blugerman G, Schavelzon D. Intralesional use of 5-FU in subcutaneous fibrosis. J Drugs Dermatol. 2003;2:169–71.
Yamamoto T, Varani J, Soong HK, Lichter PR. Effect of 5-fluorouracil and mitomycin on cultured rabbit subconjunctival fibroblast. Ophthalmology. 1990;97:1202–10.
Yeatts RP, Ford JG, Stanton CA, Reed JW. Topical 5-fluorouracil in the intra epithelial neoplasia of the conjuntiva and cornea. Ophthalmology. 1995;102:1388–44.
Lee DA, Shapourifar-Tehrani S, Kitada S. The effect of 5-fluorouracil and cytarabine on human fibroblasts from Tenon’s capsule. Invest Ophthalmol Vis Sci. 1990;31:1848–55.
Schellini SA, Shiratori CN, Spirandelli PH, Shiratori CA, Padovani CR. Uso do 5-fluorouracil no intra-operatĂłrio da cirurgia do pterĂgio. Arq Bras Oftalmol. 2000;63(2):111–4.
Acali A, Khan U, Khaw PT, McGrouther AD. Decrease in adhesión formation by a single application of 5Fluorouracil after flexor tendon injury. Plast Reconstr Surg. 1999;103(1):151–8.
Jemec B, Linge C, Grobbelaar AO, Smith PJ, Sanders R, McGrouther DA. The effect of 5-fluorouracil on Dupuytren fibroblast proliferation and differentiation. Chir Main. 2000;19(1):15–22.
Viera MH, Amini S, Valins W, Berman B. Innovative therapies in the treatment of keloids and hypertrophic scars. J Clin Aesthet Dermatol. 2010;3(5):20–6.
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Blugerman, G., Schavelzon, D., Wexler, G., Lotocky, M. (2017). Pathological Umbilical Scar Management with 5-FU Injections. In: Shiffman, M. (eds) Adult Umbilical Reconstruction. Springer, Cham. https://doi.org/10.1007/978-3-319-43887-0_11
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DOI: https://doi.org/10.1007/978-3-319-43887-0_11
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