Abstract
Melanomas with indistinct clinical margins are at increased risk for local recurrence or positive microscopic margins after conventional excision, particularly lentigo maligna melanoma (LMM). If reconstruction is performed immediately after conventional excision and before confirming clear margins, patients may require additional excisions and more complex reconstruction procedures. Mohs micrographic surgery (MMS) with melanocytic immunostains addresses these challenges with immediate microscopic examination of the entire peripheral and deep surgical margin to identify and remove subclinical LMM prior to reconstruction. This chapter explains MMS for LMM and how it can improve management compared to conventional excision.
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References
Trost LB, Bailin PL. History of Mohs surgery. Dermatol Clin. 2011;29(2):135–9.
Mohs FE. Mohs micrographic surgery. A historical perspective. Dermatol Clin. 1989;7(4):609–11.
Zitelli JA, Brown C, Hanusa BH. Mohs micrographic surgery for the treatment of primary cutaneous melanoma. J Am Acad Dermatol. 1997;37(2 Pt 1):236–45.
Prieto VG, Argenyi ZB, Barnhill RL, Duray PH, Elenitsas R, From L, et al. Are en face frozen sections accurate for diagnosing margin status in melanocytic lesions? Am J Clin Pathol. 2003;120(2):203–8. doi:10.1309/J1Q0-V35E-UTMV-R193.
Barlow RJ, White CR, Swanson NA. Mohs’ micrographic surgery using frozen sections alone may be unsuitable for detecting single atypical melanocytes at the margins of melanoma in situ. Br J Dermatol. 2002;146(2):290–4.
Cohen LM, McCall MW, Hodge SJ, Freedman JD, Callen JP, Zax RH. Successful treatment of lentigo maligna and lentigo maligna melanoma with Mohs’ micrographic surgery aided by rush permanent sections. Cancer. 1994;73(12):2964–70.
Zitelli JA, Moy RL, Abell E. The reliability of frozen sections in the evaluation of surgical margins for melanoma. J Am Acad Dermatol. 1991;24(1):102–6.
Bienert TN, Trotter MJ, Arlette JP. Treatment of cutaneous melanoma of the face by Mohs micrographic surgery. J Cutan Med Surg. 2003;7(1):25–30. doi:10.1007/s10227-002-1161-7.
Griego RD, Zitelli JA. Mohs micrographic surgery using HMB-45 for a recurrent acral melanoma. Dermatol Surg. 1998;24(9):1003–6.
Zalla MJ, Lim KK, Dicaudo DJ, Gagnot MM. Mohs micrographic excision of melanoma using immunostains. Dermatol Surg. 2000;26(8):771–84.
Albertini JG, Elston DM, Libow LF, Smith SB, Farley MF. Mohs micrographic surgery for melanoma: a case series, a comparative study of immunostains, an informative case report, and a unique mapping technique. Dermatol Surg. 2002;28(8):656–65.
Cherpelis BS, Moore R, Ladd S, Chen R, Glass LF. Comparison of MART-1 frozen sections to permanent sections using a rapid 19-minute protocol. Dermatol Surg. 2009;35(2):207–13. doi:10.1111/j.1524-4725.2008.34411.x.
Kelley LC, Starkus L. Immunohistochemical staining of lentigo maligna during Mohs micrographic surgery using MART-1. J Am Acad Dermatol. 2002;46(1):78–84.
Viola KV, Rezzadeh KS, Gonsalves L, Patel P, Gross CP, Yoo J, et al. National utilization patterns of Mohs micrographic surgery for invasive melanoma and melanoma in situ. J Am Acad Dermatol. 2015;72(6):1060–5. doi:10.1016/j.jaad.2015.02.1122.
Bricca GM, Brodland DG, Ren D, Zitelli JA. Cutaneous head and neck melanoma treated with Mohs micrographic surgery. J Am Acad Dermatol. 2005;52(1):92–100. doi:10.1016/j.jaad.2004.08.038.
Kunishige JH, Brodland DG, Zitelli JA. Surgical margins for melanoma in situ. J Am Acad Dermatol. 2012;66(3):438–44. doi:10.1016/j.jaad.2011.06.019.
Etzkorn JR, Sobanko JF, Elenitsas R, Newman JG, Goldbach H, Shin TM, et al. Low recurrence rates for in situ and invasive melanomas using Mohs micrographic surgery with melanoma antigen recognized by T cells 1 (MART-1) immunostaining: tissue processing methodology to optimize pathologic staging and margin assessment. J Am Acad Dermatol. 2015;72(5):840–50. doi:10.1016/j.jaad.2015.01.007.
Newman J, Beal M, Schram SE, Lee PK. Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma using Mel-5 immunostaining: an update from the University of Minnesota. Dermatol Surg. 2013;39(12):1794–9. doi:10.1111/dsu.12356.
Bhardwaj SS, Tope WD, Lee PK. Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma using Mel-5 immunostaining: University of Minnesota experience. Dermatol Surg. 2006;32(5):690–6. doi:10.1111/j.1524-4725.2006.32142.x. discussion 6–7.
Iorizzo 3rd LJ, Chocron I, Lumbang W, Stasko T. Importance of vertical pathology of debulking specimens during Mohs micrographic surgery for lentigo maligna and melanoma in situ. Dermatol Surg. 2013;39(3 Pt 1):365–71. doi:10.1111/dsu.12078.
Huilgol SC, Selva D, Chen C, Hill DC, James CL, Gramp A, et al. Surgical margins for lentigo maligna and lentigo maligna melanoma: the technique of mapped serial excision. Arch Dermatol. 2004;140(9):1087–92. doi:10.1001/archderm.140.9.1087.
Cohen LM, McCall MW, Zax RH. Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma. A follow-up study. Dermatol Surg. 1998;24(6):673–7.
Somach SC, Taira JW, Pitha JV, Everett MA. Pigmented lesions in actinically damaged skin. Histopathologic comparison of biopsy and excisional specimens. Arch Dermatol. 1996;132(11):1297–302.
Bub JL, Berg D, Slee A, Odland PB. Management of lentigo maligna and lentigo maligna melanoma with staged excision: a 5-year follow-up. Arch Dermatol. 2004;140(5):552–8. doi:10.1001/archderm.140.5.552.
Mahoney MH, Joseph M, Temple CL. The perimeter technique for lentigo maligna: an alternative to Mohs micrographic surgery. J Surg Oncol. 2005;91(2):120–5.
Gardner KH, Hill DE, Wright AC, Brewer JD, Arpey CJ, Otley CC, et al. Upstaging from melanoma in situ to invasive melanoma on the head and neck after complete surgical resection. Dermatol Surg. 2015;41(10):1122–5. doi:10.1097/DSS.0000000000000466.
Bene NI, Healy C, Coldiron BM. Mohs micrographic surgery is accurate 95.1 % of the time for melanoma in situ: a prospective study of 167 cases. Dermatol Surg. 2008;34(5):660–4. doi:10.1111/j.1524-4725.2007.34124.x.
Bricca GM, Brodland DG, Zitelli JA. Immunostaining melanoma frozen sections: the 1-hour protocol. Dermatol Surg. 2004;30(3):403–8.
Kimyai-Asadi A, Ayala GB, Goldberg LH, Vujevich J, Jih MH. The 20-minute rapid MART-1 immunostain for malignant melanoma frozen sections. Dermatol Surg. 2008;34(4):498–500. doi:10.1111/j.1524-4725.2007.34095.x.
Glass LF, Raziano RM, Clark GS, Higgins HW, Ladd S, Lien MH, et al. Rapid frozen section immunostaining of melanocytes by microphthalmia-associated transcription factor. Am J Dermatopathol. 2010;32(4):319–25.
Christensen KN, Hochwalt PC, Hocker TL, Roenigk RK, Brewer JD, Baum CL, et al. Comparison of MITF and melan-A immunohistochemistry during Mohs surgery for lentigo maligna-type melanoma in situ and lentigo maligna melanoma. Dermatol Surg. 2016;42(2):167–75.
Plaza JA, Bonneau P, Prieto V, Sangueza M, Mackinnon A, Suster D, et al. Desmoplastic melanoma: an updated immunohistochemical analysis of 40 cases with a proposal for an additional panel of stains for diagnosis. J Cutan Pathol. 2015.
Robinson JK. Current histologic preparation methods for Mohs micrographic surgery. Dermatol Surg. 2001;27(6):555–60.
Walling HW, Scupham RK, Bean AK, Ceilley RI. Staged excision versus Mohs micrographic surgery for lentigo maligna and lentigo maligna melanoma. J Am Acad Dermatol. 2007;57(4):659–64. doi:10.1016/j.jaad.2007.02.011.
Hou JL, Reed KB, Knudson RM, Mirzoyev SA, Lohse CM, Frohm ML, et al. Five-year outcomes of wide excision and Mohs micrographic surgery for primary lentigo maligna in an academic practice cohort. Dermatol Surg. 2015;41(2):211–8. doi:10.1097/DSS.0000000000000248.
Temple CL, Arlette JP. Mohs micrographic surgery in the treatment of lentigo maligna and melanoma. J Surg Oncol. 2006;94(4):287–92. doi:10.1002/jso.20305.
Ad Hoc Task F, Connolly SM, Baker DR, Coldiron BM, Fazio MJ, Storrs PA, et al. AAD/ACMS/ASDSA/ASMS 2012 appropriate use criteria for Mohs micrographic surgery: a report of the American Academy of Dermatology, American College of Mohs Surgery, American Society for Dermatologic Surgery Association, and the American Society for Mohs Surgery. J Am Acad Dermatol. 2012;67(4):531–50.
Etzkorn JR, Sobanko JF, Shin TM, Elenitsas R, Chu EY, Gelfand JM et al. Correlation between appropriate use criteria and the frequency of subclinical spread or reconstruction with a flap or graft for melanomas treated with Mohs surgery with melanoma antigen recognized by T cells 1 immunostaining. Dermatol Surg; 2016.
Kiehl P, Matthies B, Ehrich K, Volker B, Kapp A. Accuracy of frozen section measurements for the determination of Breslow tumour thickness in primary malignant melanoma. Histopathology. 1999;34(3):257–61.
33. Melanoma. In: NCCN clinical practice guidelines in oncology; 2016. http://www.nccn.org/professionals/physician_gls/pdf/melanoma.pdf. Accessed 15 Jan 2016.
Rapini RP. False-negative surgical margins. Adv Dermatol. 1995;10:137–48. discussion 49.
Abide JM, Nahai F, Bennett RG. The meaning of surgical margins. Plast Reconstr Surg. 1984;73(3):492–7.
Kimyai-Asadi A, Katz T, Goldberg LH, Ayala GB, Wang SQ, Vujevich JJ, et al. Margin involvement after the excision of melanoma in situ: the need for complete en face examination of the surgical margins. Dermatol Surg. 2007;33(12):1434–9. discussion 9–41.
Florell SR, Boucher KM, Leachman SA, Azmi F, Harris RM, Malone JC, et al. Histopathologic recognition of involved margins of lentigo maligna excised by staged excision: an interobserver comparison study. Arch Dermatol. 2003;139(5):595–604.
Hendi A, Brodland DG, Zitelli JA. Melanocytes in long-standing sun-exposed skin: quantitative analysis using the MART-1 immunostain. Arch Dermatol. 2006;142(7):871–6. doi:10.1001/archderm.142.7.871.
Barlow JO, Maize Sr J, Lang PG. The density and distribution of melanocytes adjacent to melanoma and nonmelanoma skin cancers. Dermatol Surg. 2007;33(2):199–207.
Kunishige JH, Brodland DG, Zitelli JA. Surgical margins for melanoma in situ: when 5-mm margins are really 9 mm. J Am Acad Dermatol. 2015;72(4):745. doi:10.1016/j.jaad.2014.12.016.
Aiello Bowles EJ, Tuzzio L, Wiese CJ, Kirlin B, Greene SM, Clauser SB, et al. Understanding high-quality cancer care: a summary of expert perspectives. Cancer. 2008;112(4):934–42.
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Shin, T.M., Sobanko, J.F., Etzkorn, J.R., Miller, C.J. (2017). Mohs Surgery for Lentigo Maligna Melanoma. In: Nehal, K., Busam, K. (eds) Lentigo Maligna Melanoma. Springer, Cham. https://doi.org/10.1007/978-3-319-43787-3_7
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