Percutaneous Left Atrial Appendage Closure: Rational, Patient Selection, and Preoperative Evaluation

  • Marco Mennuni
  • Carlo PenzoEmail author
  • Giuseppe Ferrante
  • Giulio Stefanini
  • Bernhard Reimers


Atrial fibrillation (AF) is the most common arrhythmia, affecting 1–2 % of worldwide population, the incidence is 0.05 % cases per year, and it is expected to more than double by 2050 in the western countries [1]. AF presence increases the risk of embolic stroke by four- to fivefold [2] and results in stroke incidence of 2–5 % per year in untreated patients [3]. Such disabling complication is mainly related to thrombus formation within the left atrial appendage (LAA) [4]. Furthermore, among patients with AF and history of stroke, the rate of new embolic events may increase up to 12 % per year if patients are not on oral anticoagulants and is at 3 % per year in patients who are properly under medical treatment [2].


Oral Anticoagulation Left Atrial Appendage CHADS2 Score Left Atrial Appendage Thrombus Left Atrial Appendage Occlusion 
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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  • Marco Mennuni
    • 1
  • Carlo Penzo
    • 2
    Email author
  • Giuseppe Ferrante
    • 1
  • Giulio Stefanini
    • 1
  • Bernhard Reimers
    • 1
  1. 1.Cardiovascular DepartmentHumanitas Research HospitalMilanItaly
  2. 2.Cardiovascular DepartmentMirano HospitalMiranoItaly

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