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Antibiotic Susceptibility of Kingella kingae

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Advances in Understanding Kingella kingae

Part of the book series: SpringerBriefs in Immunology ((BRIEFSIMMUN))

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Abstract

Most isolates of Kingella kingae are susceptible to the antimicrobial agents that are administered empirically to children with suspected skeletal system infections or bacteremia. A TEM-1 β-lactamase is present in ~ 10 % of oropharyngeal isolates and a variable percentage of invasive isolates and can be encoded on a plasmid or on the chromosome. The TEM-1 β-lactamase is rare in continental Europe, Israel, and Canada but is common in Reykjavik (Iceland) and Minneapolis, Minnesota (USA). As a measure of caution, all invasive K. kingae isolates should be assessed for β-lactamase activity using the sensitive nitrocefin method. With rare exceptions, K. kingae is susceptible to rifampin, macrolides, aminoglycosides, fluoroquinolones, and tetracyclines but has relatively high MIC values to isoxazolylpenicillins such as oxacillin. Of relevance in regions where community-associated methicillin-resistant Staphylococcus aureus infections are common, most isolates are resistant to clindamycin, and all isolates are resistant to glycopeptide antibiotics such as vancomycin.

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Author information

Authors and Affiliations

  1. EUCAST Development Laboratory, Växjö, Sweden

    Gunnar Kahlmeter & Erika Matuschek

  2. Clinical Microbiology Laboratory, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, 84101, Israel

    Pablo Yagupsky

Authors
  1. Gunnar Kahlmeter
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  2. Erika Matuschek
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  3. Pablo Yagupsky
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Corresponding author

Correspondence to Pablo Yagupsky .

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Editors and Affiliations

  1. Physician-in-Chief, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Joseph W. St. Geme, III

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Kahlmeter, G., Matuschek, E., Yagupsky, P. (2016). Antibiotic Susceptibility of Kingella kingae . In: St. Geme, III, J. (eds) Advances in Understanding Kingella kingae. SpringerBriefs in Immunology. Springer, Cham. https://doi.org/10.1007/978-3-319-43729-3_6

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