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Surgical Intervention for Indeterminate Thyroid Nodules

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Management of Thyroid Nodules and Differentiated Thyroid Cancer

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Abstract

Thyroid nodules are common and have a ~5 % risk of malignancy. On fine-needle aspiration biopsy, nodules classified in one of the three indeterminate Bethesda categories including atypia of undetermined significance/follicular lesion of undetermined significance, follicular neoplasm/suspicious for follicular neoplasm, and suspicious for malignancy have varying rates of malignancy with predicted probabilities of cancer of 5–15 %, 15–30 %, and 60–75 %, respectively. The optimal management of the indeterminate nodule is dependent on cytology category and concern for malignancy and can be further modified by preoperative assessment of clinical, sonographic, and molecular risk factors. Either thyroid lobectomy or total thyroidectomy can provide definitive diagnosis.

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Authors and Affiliations

  1. Department of Surgery, Division of Endocrine Surgery and Surgical Oncology, University of Pittsburgh, Pittsburgh, PA, USA

    Snehal G. Patel MD & Linwah Yip MD

  2. University of Pittsburgh School of Medicine, Suite 101-3471 Fifth Avenue, Pittsburgh, PA, 15213, USA

    Linwah Yip MD

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  1. Snehal G. Patel MD
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Correspondence to Linwah Yip MD .

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  1. Endocrine Surgery, Department of Surgery, Duke University Medical Center Duke Cancer Institute, Durham, North Carolina, USA

    Sanziana A. Roman

  2. Department of Surgery, Duke University Medical Center Duke Cancer Institute, Durham, North Carolina, USA

    Julie Ann Sosa

  3. Division of Surgical Oncology and Endocrine Surgery, Vanderbilt Endocrine Surgery Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA

    Carmen C. Solórzano

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Patel, S.G., Yip, L. (2017). Surgical Intervention for Indeterminate Thyroid Nodules. In: Roman, S., Sosa, J., Solórzano, C. (eds) Management of Thyroid Nodules and Differentiated Thyroid Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-43618-0_10

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