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AMP-activated Protein Kinase pp 203–226Cite as

AMPK and Cancer

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Part of the book series: Experientia Supplementum ((EXS,volume 107))

Abstract

This chapter focuses on the role of AMPK as a stress-response molecule with an emphasis on its duplex implication in carcinogenesis and cancer drug resistance. AMPK is closely correlated to the tumor-suppressive functions of LKB1 and P53, consequently modulating the activity of cellular survival signaling such as mTOR and Akt, leading to cell growth inhibition and cell cycle arrest. On the contrary, AMPK is tightly involved in cancer drug resistance via interacting with multiple known mechanisms of chemoresistance such as ABCG2 expression, autophagy induction, and cancer stem cells enrichment. Targeting AMPK has become a novel strategy for cancer prevention and treatment.

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Conflict of Interests

No potential conflicts of interest exist.

Acknowledgements This work was supported by the National Natural Science Foundation of China (81402173 and 81573651) and Pearl River S&T Nova Program of Guangzhou (201506010098).

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Authors and Affiliations

  1. Department of Mammary Disease, Guangdong Provincial Hospital of Chinese Medicine, The Second Clinical Collage of Guangzhou University of Chinese Medicine, Guangzhou, China

    Zhiyu Wang & Pengxi Liu

  2. Department of Breast Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China

    Neng Wang & Xiaoming Xie

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  1. Zhiyu Wang
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  2. Neng Wang
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  3. Pengxi Liu
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  4. Xiaoming Xie
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Correspondence to Zhiyu Wang .

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Editors and Affiliations

  1. Oral Medicine Department, Universidad de Sevilla, Sevilla, Spain

    Mario D. Cordero

  2. INSERM U1016 Institut Cochin CNRS UMR 8104, Université Paris Descartes, Paris, France

    Benoit Viollet

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Wang, Z., Wang, N., Liu, P., Xie, X. (2016). AMPK and Cancer. In: Cordero, M., Viollet, B. (eds) AMP-activated Protein Kinase. Experientia Supplementum, vol 107. Springer, Cham. https://doi.org/10.1007/978-3-319-43589-3_9

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