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AMPK in Cardiovascular Diseases

  • Evangelos P. Daskalopoulos
  • Cécile Dufeys
  • Christophe Beauloye
  • Luc BertrandEmail author
  • Sandrine Horman
Chapter
Part of the Experientia Supplementum book series (EXS, volume 107)

Abstract

This chapter summarizes the implication of AMP-activated protein kinase (AMPK) in the regulation of various physiological and pathological cellular events of great importance for the maintenance of cardiac function. These include the control of both metabolic and non-metabolic elements targeting the different cellular components of the cardiac tissue, i.e., cardiomyocytes, fibroblasts, and vascular cells. The description of the multifaceted action of the two AMPK catalytic isoforms, α1 and α2, emphasizes the general protective action of this protein kinase against the development of critical pathologies like myocardial ischemia, cardiac hypertrophy, diabetic cardiomyopathy, and heart failure.

Keywords

AMPK Heart Ischemia Ischemia-reperfusion Metabolism Myocardial infarction Hypertrophy Fibrosis Left ventricular remodeling Heart failure 

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Evangelos P. Daskalopoulos
    • 1
    • 2
  • Cécile Dufeys
    • 1
  • Christophe Beauloye
    • 1
    • 3
  • Luc Bertrand
    • 1
    Email author
  • Sandrine Horman
    • 1
  1. 1.Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pole of Cardiovascular ResearchBrusselsBelgium
  2. 2.Cardiovascular Research (Care) InstituteAthens, IoanninaGreece
  3. 3.Division of CardiologyCliniques universitaires Saint-LucBrusselsBelgium

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