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Redox-Responsive Nano-Delivery Systems for Cancer Therapy

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Intracellular Delivery III

Part of the book series: Fundamental Biomedical Technologies ((FBMT))

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Abstract

Stimuli-responsive nano-carrier systems have been pursued with great interest due to their advantages such as controlled drug release, improved pharmacokinetics and pharmacodynamics, and reduced side effects of the drugs. These nano-carriers have potential to accumulate effectively into the tumor due to “enhanced permeability and retention” (EPR) effect and advancements in surface science further allow active targeting strategies. Development of some such nano-vectors is driven by hallmark characteristics of tumor microenvironment such as hypoxia, acidic pH, and reducing biologically-relevant milieu. This chapter highlights the features of self-regulated internally controlled redox-responsive nano-carrier systems, opportunities presented by them and the promise these “intelligent” delivery vectors offer in improving existing cancer therapeutic approaches.

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Abbreviations

ABC:

ATP binding casette

cGLP:

Current Good Laboratory Practices

cGMP:

Current Good Manufacturing Practices

CNC:

Cellulose nanocrystals

CPP-SA:

1,3-bis(carboxyphenoxy) propane-sebacic acid

DOPE:

Dioleoyl phosphatidylethanolamine

DTT:

Dithiothreitol

ECM:

Extracellular matrix

EGFR:

Epidermal growth factor receptor

EPR:

Enhanced permeability and retention

FDA:

Food and Drug Administration

GSH:

Glutathione

HIF:

Hypoxia inducible factor

MMP:

Matrix metalloproteinase

PDMAEMA:

Poly(2-(dimethylamino) ethyl methacrylate)

PEG:

Poly(ethylene glycol)

TMBQ:

Trimethyl-locked benzoquinone

VCAM:

Vascular cell adhesion molecule

VEGF:

Vascular endothelial growth factor

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Authors and Affiliations

  1. Department of Pharmaceutical Sciences, School of Pharmacy, Bouve College of Health Sciences, Northeastern University, 140 The Fenway Building, 360 Huntington Avenue, Boston, MA, 02115, USA

    Amit Singh, Thanh-Huyen Tran & Mansoor M. Amiji

Authors
  1. Amit Singh
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  2. Thanh-Huyen Tran
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  3. Mansoor M. Amiji
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Corresponding author

Correspondence to Mansoor M. Amiji .

Editor information

Editors and Affiliations

  1. Biomolecular and Chemical Engineering, Vanderbilt University Biomolecular and Chemical Engineering, Nashville, Tennessee, USA

    Aleš Prokop

  2. Pharmaceutical Sciences, Midwestern University Pharmaceutical Sciences, GLENDALE, Arizona, USA

    Volkmar Weissig

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Singh, A., Tran, TH., Amiji, M.M. (2016). Redox-Responsive Nano-Delivery Systems for Cancer Therapy. In: Prokop, A., Weissig, V. (eds) Intracellular Delivery III. Fundamental Biomedical Technologies. Springer, Cham. https://doi.org/10.1007/978-3-319-43525-1_10

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