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Salivary Gland Development and Regeneration pp 75–91Cite as

Histologic Changes in the Salivary Glands Following Radiation Therapy

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Abstract

Therapeutic radiation for cancer of the head and neck damages salivary glands that are situated between the radiation source and the target tumor and its metastases. With moderate to high radiation exposure, salivary glands are devastated and regeneration is limited. The resulting severe reduction in saliva has detrimental effects on the teeth and oral mucosa. The purpose of this review is to describe some of the salient histologic features of salivary gland structures and cells, how these are functionally related to salivary production, and thus how radiation-induced loss and functional impairment of each type of structure may contribute to reduced quantity and quality of saliva.

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Acknowledgments

I thank Su-Wan Chen, Helen Cormier, Edward Flores, Lyvouch Filkoski, Patricia Lewis, Rodney McNutt, and Shirley McLaughlin for preparing the tissues for morphologic evaluation. The research enabling the illustrations was supported in part by grants DE-102, DE-03002, 1-K4-DE-40-019, and DE-14995 from the National Institute of Dental and Craniofacial Research, the National Institutes of Health, Bethesda, MD, the Universities of Colorado, Minnesota, and Washington, and by Research Career and Merit Review Awards from the United States Department of Veterans Affairs. Figures 4.5 and 4.6, the legends to these figures, and some of the text are reproduced from Redman [73], with prior permission.

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  1. Chief, Oral Pathology Research Laboratory, Department of Veterans Affairs Medical Center, Washington, DC, 20422, USA

    Robert S. Redman DDS

  2. Adjunct Professor, University of Maryland School of Dentistry, Baltimore, MD, USA

    Robert S. Redman DDS

  3. Adjunct Scientist, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA

    Robert S. Redman DDS

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  1. Oral and Maxillofacial Diagnostic Sciences, University of Florida, Gainesville, Florida, USA

    Seunghee Cha

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Redman, R.S. (2017). Histologic Changes in the Salivary Glands Following Radiation Therapy. In: Cha, S. (eds) Salivary Gland Development and Regeneration. Springer, Cham. https://doi.org/10.1007/978-3-319-43513-8_4

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