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Implications of Salivary Gland Developmental Mechanisms for the Regeneration of Adult Damaged Tissues

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Salivary Gland Development and Regeneration

Abstract

The convergence of the fields of tissue engineering and regenerative medicine provides a potential blueprint to repair damaged tissues. Accordingly, a range of therapeutic applications have emerged that hold great potential to regenerate branching organs, such as salivary glands. This unique saliva-secreting organ is required for proper oral health, lubrication, immunity, and food digestion but is susceptible to damage either by co-irradiation as a side effect of radiotherapy cancer treatment, autoimmune-related Sjögren syndrome, disease-related medications, or surgical resection. This chapter focuses on fundamental cellular and molecular processes occurring during organ ontogenesis and in developing branching glands. We cover the growth of the epithelial compartment, which is the major functional component of the gland, but also how surrounding niches such as mesenchymal, endothelial, and neuronal cells communicate, intertwine, and influence the formation of glands and other branching organs. Finally, we highlight how this key information has created new regenerative-related approaches and how these impact future clinical translation.

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Acknowledgments

I thank Dr. Wendy Knosp and Dr. Matthew Hoffman (National Institute for Dental and Craniofacial Research, NIH, DHHS, USA) for critical proofreading.

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  1. University of Michigan, School of Dentistry, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA

    Isabelle M. A. Lombaert PhD

  2. Biointerfaces Institute, 2800 Plymouth Road, Ann Arbor, MI, 48109, USA

    Isabelle M. A. Lombaert PhD

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Correspondence to Isabelle M. A. Lombaert PhD .

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  1. Oral and Maxillofacial Diagnostic Sciences, University of Florida, Gainesville, Florida, USA

    Seunghee Cha

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Lombaert, I.M.A. (2017). Implications of Salivary Gland Developmental Mechanisms for the Regeneration of Adult Damaged Tissues. In: Cha, S. (eds) Salivary Gland Development and Regeneration. Springer, Cham. https://doi.org/10.1007/978-3-319-43513-8_1

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