Abstract
Heart disease is the leading cause of death in the United States. Many treatments have been developed for patients with end-stage heart failure, among which heart transplantation remains the standard. However, the persistent shortage of available donor organs has resulted in an ever-increasing waitlist for transplantation, as well as longer waiting periods prior to surgery. Within the last 15 years, major strides have been made in the area of mechanical circulatory support, allowing patients with medically refractory heart failure a number of exciting and practical alternatives to heart transplantation. This chapter will focus on the use of implantable long-term mechanical circulatory support devices as bridge to transplant and destination therapy for adult patients with advanced heart failure in the United States.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Hunt SA, Abraham WT, Chin MH et al (2005) ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure). Circulation 112(12):e154–e235
Mulligan MS, Shearon TH, Weill D, Pagani FD, Moore J, Murray S (2008) Heart and lung transplantation in the United States, 1997-2006. Am J Transplant 8(4p2):977–987
Rose EA, Gelijns AC, Moskowitz AJ et al (2001) Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group. Long-term mechanical left ventricular assistance for end-stage heart failure. N Engl J Med 345(20):1435–1443
Starling RC, Naka Y, Boyle AJ et al (2011) Results of the post-U.S. Food and Drug Administration-approval study with a continuous flow left ventricular assist device as a bridge to heart transplantation: a prospective study using the INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support). J Am Coll Cardiol 57(19):1890–1898
Kirklin JK, Naftel DC, Pagani FD et al (2014) Sixth INTERMACS annual report: a 10,000-patient database. J Heart Lung Trans 33(6):555–564
Kirklin JK, Naftel DC, Pagani FD et al (2015) Seventh INTERMACS annual report: 15,000 patients and counting. J Heart Lung Transplant 34(12):1495–1504
Slaughter MS, Rogers JG, Milano CA et al (2009) Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med 361(23):2241–2251
Pagani FD, Miller LW, Russell SD et al (2009) Extended mechanical circulatory support with a continuous-flow rotary left ventricular assist device. J Am Coll Cardiol 54(4):312–321
Park SJ, Tector A, Piccioni W et al (2005) Left ventricular assist device as destination therapy; a new look at survival. J Thorac Cardiovasc Surg 129(1):9–17
Peura JL, Colvin-Adams M, Francis GS et al (2012) Recommendations for the use of mechanical circulatory support: device strategies and patient selection: a scientific statement from the American Heart Association. Circulation 126(22):2648–2667
Anand I, Maggioni A, Burton P et al (2006) The seattle heart failure model: prediction of survival in heart failure. Circulation 113(11):1424–1433
Fitzpatrick JR, Frederick JR, Hiesinger W et al (2009) Early planned institution of biventricular mechanical circulatory support results in improved outcomes compared with delayed conversion of a left ventricular assist device to a biventricular assist device. J Thorac Cardiovasc Surg 137(4):971–977
Atluri P, Goldstone AB, Fairman AS et al (2013) Predicting right ventricular failure in the modern, continuous flow left ventricular assist device era. Ann Thorac Surg 96(3):857–864
Miller LW, Pagani FD, Russell SD et al (2007) Use of a continuous-flow device in patients awaiting heart transplantation. N Engl J Med 357(9):885–896
Mancini D, Lietz K (2010) Selection of cardiac transplantation candidates in 2010. Circulation 122(2):173–183 Review
Freudenberger RS, Tawfik I, Shinnar M, Pendergast T (2009) Panel-reactive screening and treatment practices following bridge to transplantation ventricular assist device placement. Transplant Proc 41(5):1813–1815
Baldwin JT, Mann DL (2011) NHLBI’s program for VAD therapy for moderately advanced heart failure: the REVIVE-IT pilot trial. J Card Fail 16(11):855–858
Kirklin JK, Naftel DC, Pagani FD et al (2012) Long-term mechanical circulatory support (destination therapy): on track to compete with heart transplantation? J Thorac Cardiovasc Surg 144(3):584–603
Starling RC, Moazami N, Silvestry SC et al (2014) Unexpected abrupt increase in left ventricular assist device thrombosis. N Engl J Med 370(1):33–40
Aaronson KD, Slaughter MS, Miller LW et al (2012) Use of an intrapericardial, continuous-flow, centrifugal pump in patients awaiting heart transplantation. Circulation 125(25):3191–3200
Farrar DJ (2000) The Thoratec ventricular assist device: a paracorporeal pump for treating acute and chronic heart failure. Semin Thorac Cardiovasc Surg 12(3):243–250
Copeland JG, Smith RG, Arabia FA et al (2004) Cardiac replacement with a total artificial heart as a bridge to transplantation. N Engl J Med 351(9):859–867
Copeland JG, Copeland H, Gustafson M et al (2012) Experience with more than 100 total artificial heart implants. J Thorac Cardiovasc Surg 143(3):727–734
Park SJ, Milano CA, Tatooles AJ et al (2012) Outcomes in advanced heart failure patients with left ventricular assist devices for destination therapy. Circ Heart Fail 5(2):241–248
Pagani FD, Milano CA, Tatooles AJ, et al (2015) HeartWare HVAD for the treatment of patients with advanced heart failure ineligible for cardiac transplantation: results of the ENDURANCE destination therapy trial. Presented at the International Society for Heart and Lung Transplantation 35th Annual Meeting and Scientific Sessions, 15–18 Apr, Nice
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Shudo, Y., Wang, H., Goldstone, A.B., Joseph Woo, Y. (2017). Bridge to Transplant and Destination Therapy Strategies in the United States. In: Montalto, A., Loforte, A., Musumeci, F., Krabatsch, T., Slaughter, M. (eds) Mechanical Circulatory Support in End-Stage Heart Failure. Springer, Cham. https://doi.org/10.1007/978-3-319-43383-7_11
Download citation
DOI: https://doi.org/10.1007/978-3-319-43383-7_11
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-43381-3
Online ISBN: 978-3-319-43383-7
eBook Packages: MedicineMedicine (R0)