Abstract
Type 2 diabetes is becoming a common problem in young obese people and, in some parts of the world, is as common as type 1 diabetes in teenagers and young adults. However, patients that are included in the Phase III trials of new antidiabetic drugs tend to be middle-aged and elderly and, at this point in time, there is little information on the effects of sodium glucose cotransporter 2 (SGLT2) inhibitors in patients under 19 or over 75 years of age. Similarly, until there is much more safety data on SGLT2 inhibitors, these drugs are untested in pregnancy and gestational diabetes or in patients with serious liver disease. In pregnancy, the renal threshold for glucose reduces (i.e., glucose spills over into the urine at a lower blood glucose concentration), and so different clinical effects can be anticipated when compared to the nonpregnant population. Thus, this chapter will omit these patients and focus on the effects of SGLT2 inhibitors in four specific groups of patients where there is published information on efficacy, safety, or both. This includes:
Keywords
- Chronic Kidney Disease
- Chronic Kidney Disease Stage
- SGLT2 Inhibitor
- Continuous Glucose Monitoring System
- European Medicine Evaluation Agency
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Fisher, M. (2017). Using SGLT2 Inhibitors in Special Populations. In: Essentials of SGLT2 Inhibitors in Diabetes. Adis, Cham. https://doi.org/10.1007/978-3-319-43296-0_4
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DOI: https://doi.org/10.1007/978-3-319-43296-0_4
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