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Application of Proteomic Biomarkers in Livestock Disease Management

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Agricultural Proteomics Volume 2

Abstract

The applications of proteomics in animal husbanding are broad and include monitoring proteome changes in the tissue and body fluids to interpret the physiological process during growth, development and production and in the detection and management of disease. The diversity of farm animal species from cattle, sheep, goats, chickens to fish and even invertebrate aquaculture species complicate the analysis and interpretation of proteome data. The recent technological advances in extraction and fractionation techniques along with platform sensitivity and data analysis have allowed discovery of next-generation biomarkers with high sensitivity, specificity and precision. These robust biomarkers are useful in monitoring health and well-being of animals, surveillance against animal pathogens, elucidating disease mechanisms, assessing pharmacologic response to therapeutic and directing genetic selection and breeding. A literature survey revealed that discovery of proteomic biomarkers in biological fluids (serum, plasma, urine, milk, exudates, tear, semen and genital secretion) provide readily accessible sources of samples for non- or minimally-invasive and cost-effective diagnosis tools. This area of research is actively expanding and future research would profitably focus on applications of multiple biomarkers to increase the diagnosis precision in livestock disease management. Therefore this review is aimed to provide a brief overview on successful experiences in using proteomics biomarkers identified in biological fluids for livestock diseases management.

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Authors and Affiliations

  1. Agricultural Biotechnology Research Institute of Iran (ABRII), East and North-East Branch, P.O.B. 91735/844, Mashhad, Iran

    Ehsan Oskoueian

  2. Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK

    Peter David Eckersall

  3. Department of Bioinformatics, Biocenter, University of Wuerzburg, 97074, Würzburg, Germany

    Elena Bencurova & Thomas Dandekar

  4. Laboratory of Biomedical Microbiology and Immunology, Department of Microbiology and Immunology, University of Veterinary Medicine and Pharmacy in Kosice, 041 81, Kosice, Slovakia

    Elena Bencurova

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  1. Ehsan Oskoueian
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  2. Peter David Eckersall
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  3. Elena Bencurova
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  4. Thomas Dandekar
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Correspondence to Ehsan Oskoueian .

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  1. Systems Biology, Agr. Biotech. Res. Institute of Iran, Karaj, Iran

    Ghasem Hosseini Salekdeh

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Oskoueian, E., Eckersall, P.D., Bencurova, E., Dandekar, T. (2016). Application of Proteomic Biomarkers in Livestock Disease Management. In: Salekdeh, G. (eds) Agricultural Proteomics Volume 2. Springer, Cham. https://doi.org/10.1007/978-3-319-43278-6_14

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