Infant Colic

  • Valerie Sung
  • Ian St James-RobertsEmail author


Despite numerous organic theories proposed to play a role in infant colic, none have been proven to be causal. The interplay between gut microbiota, gut inflammation and the gut–brain axis in infant colic is an exciting and credible concept that is currently supported by limited evidence. Meanwhile, there is still no conclusively effective dietary treatment option for infant colic. The use of hypoallergenic formulae or maternal elimination diets can be trialled for certain crying infants with other associated clinical symptoms, but do not work for all infants with colic. How many parents can implement maternal elimination diets is unknown. Anti-reflux medications are ineffective. The probiotic Lactobacillus reuteri may be effective in certain subgroups of breastfed infants with colic, but it is not effective where infants are formula-fed.


Infant colic Colic in the infant Gut microbiota Gut–brain axis Crying in colic Lactobacillus reuteri in infant colic 


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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Centre for Community Child Health, The Royal Children’s Hospital, Murdoch Childrens Research Institute, University of MelbourneMelbourneAustralia
  2. 2.Thomas Coram Research Unit, UCL Institute of Education, University College LondonLondonUK

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