What Is the Prognostic Value of EMVI?
Vascular invasion has long been established as a poor prognostic feature in colorectal cancer. Over the past 80 years, experience in gastrointestinal pathology has led to the subclassification of vascular invasion into extramural and intramural venous invasion along with lymphatic channel involvement. This chapter will describe the prognostic significance of these changes, in addition to discussing recent developments in the accurate identification of these critical histopathological findings.
KeywordsVenous invasion Vascular invasion Lymphatic invasion
- 6.Kirsch R, Messenger DE, Riddell RH, Pollett A, Cook M, Al-Haddad S, Streutker CJ, Divaris DX, Pandit R, Newell KJ, Liu J, Price RG, Smith S, Parfitt JR, Driman DK (2013) Impact of an elastin stain on detection and Interobserver agreement among gastrointestinal and Nongastrointestinal pathologists. Am J Surg Pathol 37:200–210CrossRefPubMedGoogle Scholar
- 8.Loughrey MB, Quirke P, Shepherd N (2014) Standards and datasets for reporting cancers: dataset for colorectal cancer histopathology reports, 3rd edn. Royal College of Pathologists, London. http://www.rcpath.org/publications-media/publications/datasets/colorectal-cancer.htm Google Scholar
- 15.Suzuki A, Togashi K, Nokubi M, Koinuma K, Miyakura Y, Horie H, Lefor AT, Yasuda Y (2009) Evaluation of venous invasion by Elastica van Gieson stain and tumor budding predicts local and distant metastases in patients with T1 stage colorectal cancer. Am J Surg Pathol 33:1601–1607CrossRefPubMedGoogle Scholar
- 17.Tang LH, Berlin J, Branton P, Burgart LJ, Carter DK, Compton CC, Fitzgibbons P, Frankel WL, Halling KC, Jessup J, Kakar S, Minsky B, Nakhelh R, Washington K (2013) Protocol for the examination of specimens from patients with primary carcinoma of the colon and rectum (version 3.3). College of American Pathologists, Northfield: http://www.cap.org/ShowProperty?nodePath=/UCMCon/Contribution Folders/WebContent/pdf/colon-13protocol-3300.pdf