What Is the History of Rectal Cancer Treatment?

  • M. M. Lange
  • H. J. T. Rutten


Rectal cancer treatment has improved dramatically since the end of the nineteenth century. Although we owe a great deal to advances in technology and patient care, the driving force behind this has predominantly been the understanding of the natural history of the disease. Improved surgical techniques based on recognition of anatomical and pathologic principles as well as multimodal treatment strategies have reduced mortality from 100% to less than 4% for locally advanced rectal cancer. In order to understand the basis of modern rectal cancer treatment, it is necessary to recognize the achievements of the early pioneers in the past.


  1. 1.
    Viso L, Uriach J (1995) The first twenty operations for rectal cancer. Int J Color Dis 10(3):167–168CrossRefGoogle Scholar
  2. 2.
    Classic Articles in Colonic and Rectal Surgery (1983) Jean Zulema Amussat, 1796–1855. Notes on the possible establishment of an artificial anus in the lumbar region without entering the peritoneal cavity. Dis Colon Rectum 26(7):483–487CrossRefGoogle Scholar
  3. 3.
    Faget J (1743) Remarques sur les abces qui arrivent au fondamont.Google Scholar
  4. 4.
    Lisfranc J (1833) Mémoire sur l'éxcision de la partie inférieure du rectum devenue carcinomateuseGoogle Scholar
  5. 5.
    Billroth T (1881) Clinical surgery. The New Sydenham Society, LondonGoogle Scholar
  6. 6.
    Lockhard-Mummery JP (1926) Two hundred cases of cancer of the rectum treated by perineal excision. Br J Surg 14:110–124CrossRefGoogle Scholar
  7. 7.
    Mandle F (1929) Über 1000 sakrale Mastdarmkrebsextirpationen (aus dem Hocheneggisches Material). Dtsch Z Chir 219Google Scholar
  8. 8.
    Quénu E, Hartmann H (1899) Chirurgie du rectum. G. Steinheil, ParisGoogle Scholar
  9. 9.
    Cripps H (1890) Diseases of the rectum and the anus, 2nd edn. Churchill, LondonGoogle Scholar
  10. 10.
    Miles WE (1971) A method of performing abdomino-perineal excision for carcinoma of the rectum and of the terminal portion of the pelvic colon (1908). CA Cancer J Clin 21(6):361–364CrossRefPubMedGoogle Scholar
  11. 11.
    Miles WE (1913) A lecture on the diagnosis and treatment of cancer of the rectum: delivered at the Cancer Hospital, Brompton, on 22 January 1913. Br Med J 1(2717):166–168CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Lange MM, Rutten HJ, van de Velde CJ (2009) One hundred years of curative surgery for rectal cancer: 1908–2008. Eur J Surg Oncol 35(5):456–463CrossRefPubMedGoogle Scholar
  13. 13.
    Dukes CE, BUSSEY HJ (1958) The spread of rectal cancer and its effect on prognosis. Br J Cancer 12(3):309–320CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Dixon CF, LICHTMAN AL (1946) Anterior resection for malignant lesions of the upper part of the rectum and lower part of the sigmoid. Collect Papers Mayo Clinic Mayo Found 37:100PubMedGoogle Scholar
  15. 15.
    Steichen FM, Ravitch MM (1982) History of mechanical devices and instruments for suturing. Curr Probl Surg 19(1):1–52CrossRefPubMedGoogle Scholar
  16. 16.
    Quirke P, Durdey P, Dixon MF, Williams NS (1986) Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision. Lancet 2(8514):996–999CrossRefPubMedGoogle Scholar
  17. 17.
    Havenga K, DeRuiter MC, Enker WE, Welvaart K (1996) Anatomical basis of autonomic nerve-preserving total mesorectal excision for rectal cancer. Br J Surg 83(3):384–388CrossRefPubMedGoogle Scholar
  18. 18.
    Heald RJ, Husband EM, Ryall RD (1982) The mesorectum in rectal cancer surgery – the clue to pelvic recurrence? Br J Surg 69(10):613–616CrossRefPubMedGoogle Scholar
  19. 19.
    Junginger T, Kneist W, Heintz A (2003) Influence of identification and preservation of pelvic autonomic nerves in rectal cancer surgery on bladder dysfunction after total mesorectal excision. Dis Colon Rectum 46(5):621–628CrossRefPubMedGoogle Scholar
  20. 20.
    Mynster T, Nielsen HJ, Harling H, Bulow S (2004) Blood loss and transfusion after total mesorectal excision and conventional rectal cancer surgery. Color Dis 6(6):452–457CrossRefGoogle Scholar
  21. 21.
    Hojo K, Vernava AM III, Sugihara K, Katumata K (1991) Preservation of urine voiding and sexual function after rectal cancer surgery. Dis Colon Rectum 34(7):532–539CrossRefPubMedGoogle Scholar
  22. 22.
    Moriya Y, Sugihara K, Akasu T, Fujita S (1995) Nerve-sparing surgery with lateral node dissection for advanced lower rectal cancer. Eur J Cancer 31A(7-8):1229–1232CrossRefPubMedGoogle Scholar
  23. 23.
    Enker WE (1992) Potency, cure, and local control in the operative treatment of rectal cancer. Arch Surg 127(12):1396–1401CrossRefPubMedGoogle Scholar
  24. 24.
    Havenga K, Enker WE (2002) Autonomic nerve preserving total mesorectal excision. Surg Clin North Am 82(5):1009–1018CrossRefPubMedGoogle Scholar
  25. 25.
    Guren MG, Eriksen MT, Wiig JN et al (2005) Quality of life and functional outcome following anterior or abdominoperineal resection for rectal cancer. Eur J Surg Oncol 31(7):735–742CrossRefPubMedGoogle Scholar
  26. 26.
    Vironen JH, Kairaluoma M, Aalto AM, Kellokumpu IH (2006) Impact of functional results on quality of life after rectal cancer surgery. Dis Colon Rectum 49(5):568–578CrossRefPubMedGoogle Scholar
  27. 27.
    Jacobs M, Verdeja JC, Goldstein HS (1991) Minimally invasive colon resection (laparoscopic colectomy). Surg Laparosc Endosc 1(3):144–150PubMedGoogle Scholar
  28. 28.
    Bonjer HJ, Deijen CL, Haglind E (2015) a randomized trial of laparoscopic versus open surgery for rectal cancer. N Engl J Med 373(2):194PubMedGoogle Scholar
  29. 29.
    Buess G, Theiss R, Gunther M, Hutterer F, Pichlmaier H (1985) Transanal endoscopic microsurgery. Leber Magen Darm 15(6):271–279PubMedGoogle Scholar
  30. 30.
    Ratto C, Ricci R, Valentini V et al (2006) Neoplastic mesorectal microfoci (MMF) following neoadjuvant chemoradiotherapy: clinical and prognostic implications. Ann Surg Oncol 13(11):1393–1402CrossRefPubMedGoogle Scholar
  31. 31.
    Habr-Gama A, Perez RO, Nadalin W et al (2005) Long-term results of preoperative chemoradiation for distal rectal cancer correlation between final stage and survival. J Gastrointest Surg 9(1):90–99CrossRefPubMedGoogle Scholar
  32. 32.
    Engelen SM, Maas M, Lahaye MJ et al (2013) Modern multidisciplinary treatment of rectal cancer based on staging with magnetic resonance imaging leads to excellent local control, but distant control remains a challenge. Eur J Cancer 49(10):2311–2320CrossRefPubMedGoogle Scholar
  33. 33.
    Gerard JP, Ayzac L, Coquard R et al (1996) Endocavitary irradiation for early rectal carcinomas T1 (T2). A series of 101 patients treated with the Papillon’s technique. Int J Radiat Oncol Biol Phys 34(4):775–783CrossRefPubMedGoogle Scholar
  34. 34.
    Galler AS, Petrelli NJ, Shakamuri SP (2011) Rectal cancer surgery: a brief history. Surg Oncol 20(4):223–230CrossRefPubMedGoogle Scholar
  35. 35.
    Kapiteijn E, Marijnen CA, Nagtegaal ID et al (2001) Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl J Med 345(9):638–646CrossRefPubMedGoogle Scholar
  36. 36.
    Marijnen CA, van de Velde CJ, Putter H et al (2005) Impact of short-term preoperative radiotherapy on health-related quality of life and sexual functioning in primary rectal cancer: report of a multicenter randomized trial. J Clin Oncol 23(9):1847–1858CrossRefPubMedGoogle Scholar
  37. 37.
    Peeters KC, van de Velde CJ, Leer JW et al (2005) Late side effects of short-course preoperative radiotherapy combined with total mesorectal excision for rectal cancer: increased bowel dysfunction in irradiated patients – a Dutch colorectal cancer group study. J Clin Oncol 23(25):6199–6206CrossRefPubMedGoogle Scholar
  38. 38.
    Lahaye MJ, Engelen SM, Nelemans PJ et al (2005) Imaging for predicting the risk factors – the circumferential resection margin and nodal disease – of local recurrence in rectal cancer: a meta-analysis. Semin Ultrasound CT MR 26(4):259–268CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2018

Authors and Affiliations

  1. 1.Leiden University Medical Center (The Netherlands), Department of SurgeryLeidenThe Netherlands
  2. 2.Department of SurgeryCatharina Ziekenhuis EindhovenEindhovenThe Netherlands

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