Why Do We Have to Use Chemotherapy?

  • Noelia Tarazona
  • Valentina Gambardella
  • Marisol Huerta
  • Andrés Cervantes


The use of chemotherapy (CT) in localized rectal cancer (LARC) has two aims: first, to improve the local effect of radiotherapy by giving concomitant chemoradiation and second, to decrease systemic relapses by early treatment for occult micrometastatic disease or to shrink bulky local tumours. Neoadjuvant treatment is reserved for locally advanced disease, as defined by pelvic magnetic resonance imaging, a very useful and accurate tool to identify high-risk features for local or systemic relapse [1]. We are going to address why we have to use CT in LARC.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2018

Authors and Affiliations

  • Noelia Tarazona
    • 1
    • 2
  • Valentina Gambardella
    • 1
    • 3
  • Marisol Huerta
    • 1
  • Andrés Cervantes
    • 1
  1. 1.Department of Medical OncologyBiomedical Research Institute INCLIVA, University of ValenciaValenciaSpain
  2. 2.Rio Hortega Contract CM15/00246ValenciaSpain
  3. 3.ESMO Translational Research FellowValenciaSpain

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