When Should Postoperative Radiochemotherapy Be Performed?

  • Jeffrey R. Olsen
  • Lisa A. Kachnic


Postoperative radiochemotherapy is recommended for patients with resected stage II-III rectal cancer who did not receive preoperative therapy. In this setting, postoperative radiochemotherapy has been shown to improve local control compared to observation but is associated with higher local recurrence, increased surgical complications, and no opportunity to improve the rate of sphincter preservation compared to preoperative therapy. The extent to which modern adjuvant chemotherapy may attenuate previously reported recurrence risks and applicability of data for patients with low-risk stage II disease following total mesorectal excision is unknown.


Rectal cancer Adjuvant therapy Postoperative therapy Combined modality therapy Radiation therapy 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2018

Authors and Affiliations

  1. 1.Departments of Radiation OncologyWashington University School of MedicineSt. LouisUSA
  2. 2.Departments of Radiation OncologyBoston Medical Center, Boston University School of MedicineBostonUSA

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