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Neurobiology of Substance Abuse

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Innovations in the Treatment of Substance Addiction

Abstract

Drug dependence is understood as a complex disorder associated with biological, emotional, and social factors. Consequently, an individual might develop dependence as a result of the interaction of those factors or even one of them alone, which favors the repetitive use that leads to dependence.

The original version of this chapter was revised: Name of two authors were excluded from Chapter 2. The erratum to this chapter is available at 10.1007/978-3-319-43172-7_15

An erratum to this chapter can be found at http://dx.doi.org/10.1007/978-3-319-43172-7_15

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References

  • American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington, DC.

    Google Scholar 

  • Ashton, H. (2005). The diagnosis and management of benzodiazepine dependence. Current Opinion in Psychiatry, 18(3), 249–255. doi:10.1097/01.yco.0000165594.60434.84.

    Article  PubMed  Google Scholar 

  • Azevedo, F. A., Carvalho, L. R., Grinberg, L. T., Farfel, J. M., Ferretti, R. E., Leite, R. E., et al. (2009). Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. Journal of Comparative Neurology, 513(5), 532–541. doi:10.1002/cne.21974.

    Article  PubMed  Google Scholar 

  • Bechara, A. (2005). Decision making, impulse control and loss of willpower to resist drugs: A neurocognitive perspective. Nature Neuroscience, 8(11), 1458–1463. doi:10.1038/nn1584.

    Article  PubMed  Google Scholar 

  • Blackburn, J. R., Phillips, A. G., Jakubovic, A., & Fibiger, H. C. (1989). Dopamine and preparatory behavior: II. A neurochemical analysis. Behavioral Neuroscience, 103(1), 15–23.

    Article  PubMed  Google Scholar 

  • Carlini, E. A., Galduróz, J. C., Noto, A. R., Carlini, C. M., Oliveira, L. G., & Nappo, S. A. (2007). II Levantamento domiciliar sobre o uso de drogas psicotrópicas no Brasil: Estudo envolvendo as 108 maiores cidades do país—2005. São Paulo: Páginas & Letras.

    Google Scholar 

  • Cone, E. J. (1995). Pharmacokinetics and pharmacodynamics of cocaine. Journal of Analytical Toxicology, 19(6), 459–478.

    Article  PubMed  Google Scholar 

  • Di Chiara, G. (2002). Nucleus accumbens shell and core dopamine: Differential role in behavior and addiction. Behavioural Brain Research, 137(1–2), 75–114.

    Article  PubMed  Google Scholar 

  • Di Chiara, G., & Bassareo, V. (2007). Reward system and addiction: What dopamine does and doesn’t do. Current Opinion in Pharmacology, 7(1), 69–76. doi:10.1016/j.coph.2006.11.003.

    Article  PubMed  Google Scholar 

  • Di Chiara, G., Tanda, G., Bassareo, V., Pontieri, F., Acquas, E., Fenu, S., et al. (1999). Drug addiction as a disorder of associative learning. Role of nucleus accumbens shell/extended amygdala dopamine. Annals of the New York Academy of Sciences, 877, 461–485.

    Article  PubMed  Google Scholar 

  • Fattore, L., Fadda, P., Spano, M. S., Pistis, M., & Fratta, W. (2008). Neurobiological mechanisms of cannabinoid addiction. Molecular and Cellular Endocrinology, 286(1–2 Suppl 1), S97–S107. doi:10.1016/j.mce.2008.02.006.

    Article  PubMed  Google Scholar 

  • Fibiger, H.C. (1993). Mesolimbic dopamine: An analysis of its role in motivated behavior. Paper presentd at the Seminars in Neuroscience.

    Google Scholar 

  • Gianoulakis, C. (1996). Implications of endogenous opioids and dopamine in alcoholism: Human and basic science studies. Alcohol and Alcoholism, 31(Suppl 1), 33–42.

    Article  Google Scholar 

  • Gilpin, N. W., & Koob, G. F. (2008). Neurobiology of alcohol dependence: Focus on motivational mechanisms. Alcohol Research and Health, 31(3), 185–195.

    PubMed  PubMed Central  Google Scholar 

  • Glickman, S. E., & Schiff, B. B. (1967). A biological theory of reinforcement. Psychological Review, 74(2), 81–109.

    Article  PubMed  Google Scholar 

  • Goldstein, R. Z., & Volkow, N. D. (2002). Drug addiction and its underlying neurobiological basis: Neuroimaging evidence for the involvement of the frontal cortex. The American Journal of Psychiatry, 159(10), 1642–1652.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gong, J. P., Onaivi, E. S., Ishiguro, H., Liu, Q. R., Tagliaferro, P. A., Brusco, A., et al. (2006). Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain. Brain Research, 1071(1), 10–23. doi:10.1016/j.brainres.2005.11.035.

    Article  PubMed  Google Scholar 

  • Herz, A. (1997). Endogenous opioid systems and alcohol addiction. Psychopharmacology (Berlin), 129(2), 99–111.

    Article  Google Scholar 

  • Kalivas, P. W. (2007). Neurobiology of cocaine addiction: Implications for new pharmacotherapy. American Journal on Addictions, 16(2), 71–78. doi:10.1080/10550490601184142.

    Article  PubMed  Google Scholar 

  • Koob, G. F. (1992). Drugs of abuse: Anatomy, pharmacology and function of reward pathways. Trends in Pharmacological Sciences, 13(5), 177–184.

    Article  PubMed  Google Scholar 

  • Koob, G. F., & Bloom, F. E. (1988). Cellular and molecular mechanisms of drug dependence. Science, 242(4879), 715–723.

    Article  PubMed  Google Scholar 

  • Koob, G. F., Buck, C. L., Cohen, A., Edwards, S., Park, P. E., Schlosburg, J. E., et al. (2014). Addiction as a stress surfeit disorder. Neuropharmacology, 76, 370–382. doi:10.1016/j.neuropharm.2013.05.024.

    Article  PubMed  Google Scholar 

  • Koob, G. F., & Le Moal, M. (1997). Drug abuse: Hedonic homeostatic dysregulation. Science, 278(5335), 52–58.

    Article  PubMed  Google Scholar 

  • Koob, G. F., & Le Moal, M. (2005a). Neurobiology of addiction. Cambridge: Academic Press.

    Google Scholar 

  • Koob, G. F., & Le Moal, M. (2005b). Plasticity of reward neurocircuitry and the ‘dark side’ of drug addiction. Nature Neuroscience, 8(11), 1442–1444. doi:10.1038/nn1105-1442.

    Article  PubMed  Google Scholar 

  • Koob, G. F., & Le Moal, M. (2008). Addiction and the brain antireward system. Annual Review of Psychology, 59, 29–53. doi:10.1146/annurev.psych.59.103006.093548.

    Article  PubMed  Google Scholar 

  • Koob, G. F., & Volkow, N. D. (2010). Neurocircuitry of addiction. Neuropsychopharmacology, 35(1), 217–238. doi:10.1038/npp.2009.110.

    Article  PubMed  Google Scholar 

  • Kreek, M. J., & Koob, G. F. (1998). Drug dependence: Stress and dysregulation of brain reward pathways. Drug and Alcohol Dependence, 51(1–2), 23–47.

    Article  PubMed  Google Scholar 

  • Maldonado, R., Valverde, O., & Berrendero, F. (2006). Involvement of the endocannabinoid system in drug addiction. Trends in Neurosciences, 29(4), 225–232. doi:10.1016/j.tins.2006.01.008.

    Article  PubMed  Google Scholar 

  • Milner, P. M. (1991). Brain-stimulation reward: A review. Canadian Journal of Psychology, 45(1), 1–36.

    Article  PubMed  Google Scholar 

  • Nestler, E. J. (2005). The neurobiology of cocaine addiction. Science and Practice Perspectives, 3(1), 4–10.

    Article  PubMed  PubMed Central  Google Scholar 

  • Noël, X., Van Der Linden, M., & Bechara, A. (2006). The neurocognitive mechanisms of decision-making, impulse control, and loss of willpower to resist drugs. Psychiatry (Edgmont), 3(5), 30–41.

    Google Scholar 

  • Olds, J., & Milner, P. (1954). Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. Journal of Comparative and Physiological Psychology, 47(6), 419–427.

    Article  PubMed  Google Scholar 

  • Owen, R. T., & Tyrer, P. (1983). Benzodiazepine dependence: A review of the evidence. Drugs, 25(4), 385–398.

    Article  PubMed  Google Scholar 

  • Petursson, H., & Lader, M. H. (1981). Benzodiazepine dependence. British Journal of Addiction, 76(2), 133–145.

    Article  PubMed  Google Scholar 

  • Piazza, P. V., & Le Moal, M. (1998). The role of stress in drug self-administration. Trends in Pharmacological Sciences, 19(2), 67–74.

    Article  PubMed  Google Scholar 

  • Piazza, P. V., & Le Moal, M. L. (1996). Pathophysiological basis of vulnerability to drug abuse: Role of an interaction between stress, glucocorticoids, and dopaminergic neurons. Annual Review of Pharmacology and Toxicology, 36, 359–378. doi:10.1146/annurev.pa.36.040196.002043.

    Article  PubMed  Google Scholar 

  • Robinson, J. B. (1985). Stereoselectivity and isoenzyme selectivity of monoamine oxidase inhibitors. Enantiomers of amphetamine, N-methylamphetamine and deprenyl. Biochemical Pharmacology, 34(23), 4105–4108.

    Article  PubMed  Google Scholar 

  • Samson, H. H., & Harris, R. A. (1992). Neurobiology of alcohol abuse. Trends in Pharmacological Sciences, 13(5), 206–211.

    Article  PubMed  Google Scholar 

  • Seamans, J. K., & Yang, C. R. (2004). The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Progress in Neurobiology, 74(1), 1–58. doi:10.1016/j.pneurobio.2004.05.006.

    Article  PubMed  Google Scholar 

  • Stahl, S.M. (2010). Psicofarmacologia: Base neurocientífica e aplicações práticas (3 ed.). Guanabara Koogan.

    Google Scholar 

  • Tabakoff, B., & Hoffman, P. L. (2013). The neurobiology of alcohol consumption and alcoholism: An integrative history. Pharmacology, Biochemistry and Behavior, 113, 20–37. doi:10.1016/j.pbb.2013.10.009.

    Article  PubMed  Google Scholar 

  • Volkow, N. D., & Fowler, J. S. (2000). Addiction, a disease of compulsion and drive: Involvement of the orbitofrontal cortex. Cerebral Cortex, 10(3), 318–325.

    Article  PubMed  Google Scholar 

  • Wang, J., & Ueda, N. (2008). Role of the endocannabinoid system in metabolic control. Current Opinion in Nephrology and Hypertension, 17(1), 1–10. doi:10.1097/MNH.0b013e3282f29071.

    Article  PubMed  Google Scholar 

  • Weiss, F., Maldonado-Vlaar, C. S., Parsons, L. H., Kerr, T. M., Smith, D. L., & Ben-Shahar, O. (2000). Control of cocaine-seeking behavior by drug-associated stimuli in rats: Effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens. Proceedings of the National Academy of Sciences of the United States of America, 97(8), 4321–4326.

    Article  PubMed  PubMed Central  Google Scholar 

  • Wise, R. A. (1980). Action of drugs of abuse on brain reward systems. Pharmacology, Biochemistry and Behavior, 13(Suppl 1), 213–223.

    Article  PubMed  Google Scholar 

  • Wise, R. A. (1996). Addictive drugs and brain stimulation reward. Annual Review of Neuroscience, 19, 319–340. doi:10.1146/annurev.ne.19.030196.001535.

    Article  PubMed  Google Scholar 

  • Wise, R. A. (2002). Brain reward circuitry: Insights from unsensed incentives. Neuron, 36(2), 229–240.

    Article  PubMed  Google Scholar 

  • Wise, R. A., & Bozarth, M. A. (1987). A psychomotor stimulant theory of addiction. Psychological Review, 94(4), 469–492.

    Article  PubMed  Google Scholar 

  • World Health Organization. (2004). Neuroscience of psychoactive substance use and dependence. Geneva: World Health Organization.

    Google Scholar 

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Correspondence to André Bedendo .

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Bedendo, A., Andrade, A.L.M., Noto, A.R. (2016). Neurobiology of Substance Abuse. In: Andrade, A., De Micheli, D. (eds) Innovations in the Treatment of Substance Addiction. Springer, Cham. https://doi.org/10.1007/978-3-319-43172-7_2

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