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Sirtuins and Stress Response in Skin Cancer, Aging, and Barrier Function

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Skin Stress Response Pathways

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Abstract

Sirtuins (SIRT1-7) are mammalian counterparts of the yeast silent information regulator 2 (Sir2) and are a family of NAD-dependent protein deacetylases and ADP ribosyltransferases. Sirtuins regulate numerous pathways in metabolism, aging and cancer . They are critical modulators in the cellular response to metabolic, oxidative, or genotoxic stress. Recent advances have demonstrated the pivotal role of sirtuin proteins in aging and a wide range of diseases including cancer in many organs. Skin is the essential barrier protecting organisms against environmental insults and minimizing water loss from the body. New evidence in mouse models and in vitro systems has illustrated that sirtuins have important roles in skin physiology, in the barrier function, aging, and diseases such as skin cancer. This review summarizes recent advances in understanding how sirtuins regulate the skin stress response in skin cancer, aging, and barrier integrity at the molecular, cellular, and organismal levels, and in how modulating sirtuins may help prevent or treat skin cancer, skin barrier defects, and other skin diseases.

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Acknowledgments

We apologize to those investigators whose work could not be directly referenced owing to space limitations. Work in the authors’ laboratory was supported by NIH/NIEHS grants ES016936 and ES024373 (YYH), the American Cancer Society (ACS) grant RSG-13-078-01 (YYH), the University of Chicago Cancer Research Center (P30 CA014599), the CTSA (UL1 TR000430), and the University of Chicago Friends of Dermatology Endowment Fund. I thank Dr. Ann Motten for a critical reading of the manuscript.

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  1. Department of Medicine, Section of Dermatology, University of Chicago, 5841 S Maryland Ave, MC 5067, Chicago, IL, 60637, USA

    Yu-Ying He

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  1. Department of Pharmacology and Toxicology, College of Pharmacy & The University of Arizona Cancer Center, Department of Pharmacology and Toxicology, TUCSON, Arizona, USA

    Georg T. Wondrak

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He, YY. (2016). Sirtuins and Stress Response in Skin Cancer, Aging, and Barrier Function. In: Wondrak, G. (eds) Skin Stress Response Pathways. Springer, Cham. https://doi.org/10.1007/978-3-319-43157-4_12

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