Abstract
The multiparticulate drug product concept covering micropellets, pellets, and mini-tablets is presented as a highly feasible approach to present convenient and patient friendly medication for the geriatric population. Improved swallowability and optimized administration regimen going along with defined drug dosage are achievable. Extemporaneous preparation of medicines from standard medication can be avoided going along with improved patient safety. With one multiparticulate pellet, micropellet, or mini-tablet bulk formulation a broad range of final drug products is presentable applying well-established manufacturing technologies at viable cost.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Stegemann S, Ecker F, Maio M, Kraahs P, Wohlfahrt R, Breitkreutz J, Zimmer A, Bar-Shalom D, Hettrich P, Broegmann B. Geriatric drug therapy: neglecting the inevitable majority. Ageing Res Rev. 2010;9:384–98.
ICH Harmonised Tripartite Guideline Pharmaceutical Development Q8(R2). 2009.
Stegemann S, Gosch M, Breitkreutz J. Swallowing dysfunction and dysphagia is an unrecognized challenge for oral drug therapy. Int J Pharm. 2012;430:197–206.
Stegemann S, Rasenack N, Ecker F, Zimmer A. Geriatrische Arzneimitteltherapie – Gesellschaftliche Herausforderung und pharmazeutische Lösungsansätze. DAZ. 2011;31:44–61.
Bar-Shalom D. The challenge of automated compounding. In: Bar-Shalom D, Rose K, editors. AAPS Springer Verlag; 2014. p. 181–91.
Stegemann S. Maßgeschneiderte Arzneiformen. DAZ. 2014;46:60–5.
EMEA, Commission Guideline on the format and content of applications for agreement or modification of a paediatric investigation plan and requests for waivers or deferrals and concerning the operation of the compliance check and on criteria for assessing significant studies (2014/C 338/ 01). 2014.
Breitkreutz J, Boos J. Paediatric and geriatric drug delivery. Expert Opinion Drug Deliv. 2007;4(1):37–45.
Timpe C, Dischinger A. Drug delivery strategies for oral pediatric and geriatric products. J Asia’s Pharm Biopharm Ind. 2014.
Kauzor D, Spielmann S, Brosig H, Ross R, Blankenstein O, Kloft C. Hydrocortisone in extemporaneously compounded capsules for paediatric use: a medication safety study. In: 6th conference of the EuPFI, Athens. 2014.
Ogilvie R. Industry perspective on formulation and packaging considerations; EFPIA. 2012.
Ranmal SR, Barker SA, Tuleu C. Paediatric solid formulations. . In: Bar-Shalom D, Rose K, editors. AAPS Springer Verlag; 2014. p. 153–70.
Biyyala V, Rumondor A, Thompson K, Harris D, Flanagan F, Burlage R, Smith RL. New modalities for solid dosage forms in pediatric populations—emphasis on minitablets. In: 7th conference of the EuPFI, Brussels. 2015.
World Health Organization (WHO) Annex 5: Development of paediatric medicines: points to consider in formulation. 2012.
Frey CR. Flavor is not just a taste: taste concealing. In: Bar-Shalom D, Rose K, editors. AAPS Springer Verlag; 2014. p. 123–39.
MØller P. Orosensory perception. In: Bar-Shalom D, Rose K, editors. AAPS Springer Verlag; 2014. p. 105–21.
Soto J. Assessing the aversive taste of medicines: a comparison between rat taste panels (via the BATA model) and human taste panels. In: 7th conference of the EuPFI, Brussels. 2015.
Guhmann M, Preis M, Gerber F, Pöllinger N, Breitkreutz J, Weitschies W. Development of oral taste masked diclofenac formulations using a taste sensing system. Int J Pharm. 2012;438:81–90.
Guhmann M, Preis M, Gerber F, Poellinger N, Breitkreutz J, Weitschies W. PBP World Meeting Lisbon. 2014.
Poellinger N. Microparticulates as drug carriers for pediatric use. In: 4th conference of the EuPFI, Prague. 2012.
Czajkowska M, Sznitowska M, Kotlowska H. Development of matrix type and coated prolonged release minitablets with carbamazepine. In: 7th conference of the EuPFI, Brussels. 2015.
Grave A, Steinebrunner M, Poellinger N. Development of highly drug loaded Metoprolol pellets using MicroPx technology. Istanbul: APV World Congress; 2012.
Pöllinger N, Michaelis J, Benke K, Rupp R, Bücheler M. US Patent 5,695,784. 1997.
Struschka M, Schwarz F, Luy B, Prasch A, Pöllinger N. EP 163 137 3 A1. 2006.
Grave A, Pöllinger N. In easy coating. In: Kumpgdee-Vollrath M, Krause JP, editors. Glatt Wirbelschichttechnologie zum Coating von Pulvern, Pellets und Mikropellets. Vieweg + Teubner Verlag; 2011. p. 80–119.
Grave A, Poellinger N, Whitaker M. Development of taste masked micropellets for paediatric use—scale up to production scale. In: 6th conference of the EuPFI, Athens. 2014.
Heppner HJ, Sieber CC, Esslinger AS, Trögner J. Arzneimittelformen und Arzneimittelverabreichung in der Geriatrie. Ther Umschau. 2006;63:419–22.
Müller-Bohn T. Pädiatrie: Kinder: Stiefkinder der Arzneitherapie? 2007;DAZ 9: 63.
Grave A, Poellinger N, Whitaker M. Taste masked micropellets for pediatric use. 9th World Meeting on Pharmaceutics, Biopharmaceutics, Lisbon. 2014.
Poellinger N, Grave A. TAIN—a collaborative approach to meet patient needs in a rare disease. In: 6th conference of the EuPFI, Athens. 2014.
Capsugel, Coni-Snap Sprinkle Caps. 2015.
Lewis C, Segal J, McGovern J, Simmons J, Burley J. Mulitple unit orodispsible mini-tablets. In: 7th conference of the EuPFI, Brussels. 2015.
Bhad ME, Abdul S, Jaiswal SB, Chandewar AV, Jain JM, Sakarkar DM. MUPS tablets—a brief review. Int J Pharm Tech Res. 2010;2:847–55.
Pohl U., Führling C., Gieseler H. Neue Schmelztablette zur Migränetherapie. 2012;DAZ 14: 96.
Mostafa HF, Ibrahim MA, Sakr A. Dextromethorphan Hydrobromide orally disintegrating tablets. Pharm Ind. 2014;76:454–63.
Adam AK, Rauscher S, Zimmer C, Breitkreutz J. Multiple unit orodispersible mini-tablets. In: 7th conference of the EuPFI, Brussels. 2015.
Frey CR, Madsen JS. Liquid formulations. In: Bar-Shalom D, Rose K, editors. AAPS Springer Verlag; 2014.
Wan M, Hashimi AA, Batchelor H. Pharmacy and formulation support for clinical trials in England. In: 7th conference of the EuPFI, Brussels. 2015.
Raumedic AG, Dose Sipping Technology XStraw. 2014.
DS Technology. 2015.
Raumedic AG. 2015.
Wartenberg F. Vom Trockensaft zum Heilmittel –(k)ein Kinderspiel. 2007;DAZ 33: 36.
Arzneimittelapplikation per Sonde. 2006;DAZ 29:80.
Adare Pharmaceuticals; case study: use of minitablets technology to reliably and effectively deliver drugs through gastrostomy tube (G-tube). In: 7th conference of the EuPFI, Brussels. 2015.
Räth U, Kamann F. Medikamentenlehre für Altenpflegeberufe, 4. WVG Stuttgart: Aufl; 2015.
Schmidt V, Lipp H-P. Orale Liquida für die Pädiatrie – Entwicklung und Optimierung kindgerechter Zubereitungen DAZ. 2009;44:54.
Wenning K, Breitkreutz J. Oral drug delivery in personalized medicine: unmet needs and novel approaches Int. J Pharm. 2011;404(1–2):1–9.
Stegemann S. Treatment of the elderly; APV course 6469, Prague. 2012.
Poellinger N.; Pediatric formulations in clinical testing and the challenge of final market formulation; pp 193–203 Ed. Bar-Shalom D., Rose K.; AAPS Springer Verlag (2014).
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 American Association of Pharmaceutical Scientists
About this chapter
Cite this chapter
Pöllinger, N. (2016). Drug Product Development for Older Adults—Multiparticulate Formulations. In: Stegemann, S. (eds) Developing Drug Products in an Aging Society. AAPS Advances in the Pharmaceutical Sciences Series, vol 26. Springer, Cham. https://doi.org/10.1007/978-3-319-43099-7_16
Download citation
DOI: https://doi.org/10.1007/978-3-319-43099-7_16
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-43097-3
Online ISBN: 978-3-319-43099-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)