Abstract
The prediction of the relative biological effectiveness of ion beams requires the quantification of all the biomolecular damage processes involved in the interaction of energetic ions with biological media. Traditionally, the damage pathways have been classified as direct or indirect, the former being related to the direct action of the secondary electrons produced along the ion path with DNA molecules, while the latter are referred to the damage produced by the other chemical species generated, mainly free radicals. However, the development over the last years of the multiscale approach to ion beam cancer therapy has revealed the contribution of a new damage mechanism, not present in conventional therapy with photons or electrons: the thermo-mechanical DNA damage arising from the development of shock waves on the nanometer scale around the swift ion path. The present chapter explains the theoretical framework in which this effect is predicted and reviews the work performed over the last years to try to understand the role of this damage pathway in the mechanisms of ion beam cancer therapy.
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References
Surdutovich E, Solov’yov AV (2014) Multiscale approach to the physics of radiation damage with ions. Europ Phys J D 68:353-1–353-30
Boudaïffa B, Cloutier P, Hunting D, Huels MA, Sanche L (2000) Resonant formation of DNA strand breaks by low-energy (3 to 20 eV) electrons. Science 287:1658–1660
Surdutovich E, Solov’yov AV (2010) Shock wave initiated by an ion passing through liquid water. Phys Rev E 82:051915-1–051915-5
Surdutovich E, Solov’yov AV (2015) Transport of secondary electrons and reactive species in ion tracks. Europ Phys J D 69:193-1–193-7
Surdutovich E, Obolensky OI, Scifoni E, Pshenichnov I, Mishustin I, Solov’yov AV, Greiner W (2009) Ion-induced electron production in tissue-like media and DNA damage mechanisms. Europ Phys J D 51:63–71
de Vera P, Abril I, Garcia-Molina R, Solov’yov AV (2013) Ionization of biomolecular targets by ion impact: input data for radiobiological applications. J Phys: Conf Ser 438:012015-1–012015-10
Toulemonde M, Surdutovich E, Solov’yov AV (2009) Temperature and pressure spikes in ion-beam cancer therapy. Phys Rev E 80:031913-1–031913-9
Landau L, Lifshitz E (1987) Fluid Mechanics, vol 6 of Course of Theoretical Physics, 2nd edn. Reed-Elsevier, Oxford, Boston, Johannesburg
Zeldovich Y, Raiser Y (1966) Physics of shock waves and high-temperature hydrodynamic phenomena, vol 1. Dover Publications, Oxford, New York
Chernyj G (1994) Gas dynamics. Nauka, Moscow
Surdutovich E, Yakubovich AV, Solov’yov AV (2013) DNA damage due to thermomechanical effects caused by heavy ions propagating in tissue. Nucl Instr Meth B 314:63–65
LaVerne J (1989) Radical and molecular yields in the radiolysis of water with carbon ions. Radiat Phys Chem 34:135–143
Yakubovich AV, Surdutovich E, Solov’yov AV (2011) Atomic and molecular data needs for radiation damage modeling: multiscale approach. AIP Conf Proc 1344:230–238
Yakubovich AV, Surdutovich E, Solov’yov AV (2012) Thermomechanical damage of nucleosome by the shock wave initiated by ion passing through liquid water. Nucl Instr Meth B 279:135–139
Yakubovich AV, Surdutovich E, Solov’yov AV (2012) Damage of DNA backbone by nanoscale shock waves. J Phys: Conf Ser 373:012014-1–012014-7
Surdutovich E, Yakubovich AV, Solov’yov AV (2013) Biodamage via shock waves initiated by irradiation with ions. Sci Rep 3:1289-1–1289-6
de Vera P, Mason NJ, Currell FJ, Solov’yov AV (2016) Molecular dynamics study of accelerated ion-induced shock waves in biological media. Europ Phys J D 70:183
Bottländer D, Mücksch C, Urbassek HM (2015) Effect of swift-ion irradiation on DNA molecules: a molecular dynamics study using the REAX force field. Nucl Instr Meth B 365:622–625
MacKerell AD Jr, Bashford D, Bellott M, Dunbrack RL Jr, Evanseck JD et al (1998) All-atom empirical potential for molecular modeling and dynamics studies of proteins. J Phys Chem B 102:3586–3616
Range K, McGrath MJ, Lopez X, York DM (2004) The structure and stability of biological metaphosphate, phosphate, and phosphorane compounds in the gas phase and in solution. J Am Chem Soc 126:1654–1665
Smyth M, Kohanoff J (2012) Excess electron interactions with solvated DNA nucleotides: strand breaks possible at room temperature. J Am Chem Soc 134:9122–9125
von Sonntag C (1987) The chemical basis of radiation biology. Taylor & Francis, London
Alpen EL (1998) Radiation biophysics. Academic Press
van Duin ACT, Dasgupta S, Lorant F, Goddard WA III (2001) ReaxFF: a reactive force field for hydrocarbons. J Phys Chem A 105:9396–9409
Sushko GB, Solov’yov IA, Verkhovtsev AV, Volkov SN, Solov’yov AV (2016) Studying chemical reactions in biological systems with MBN Explorer: implementation of molecular mechanics with dynamical topology. Eur Phys J D 70:12-1–12-10
Solov’yov IA, Yakubovich AV, Nikolaev PV, Volkovets I, Solov’yov AV (2012) MesoBioNano Explorer—a universal program for multiscale computer simulations of complex molecular structure and dynamics. J Comput Chem 33:2412–2439. http://www.mbnexplorer.com
Acknowledgements
Part of the research reviewed in this chapter was developed with the support of the European Union’s COST Action MP1002, Nanoscale insights into Ion Beam Cancer Therapy. The most recent work has been done within the European Union’s (FP7-People Program, Marie Curie Actions) Initial Training Network No. 608163 “ARGENT”, Advanced Radiotherapy, Generated by Exploiting Nanoprocesses and Technologies, to which PdV acknowledges financial support.
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de Vera, P., Mason, N.J., Surdutovich, E., Solov’yov, A.V. (2017). Thermo-Mechanical Damage of Biomolecules Under Ion-Beam Radiation. In: Solov’yov, A. (eds) Nanoscale Insights into Ion-Beam Cancer Therapy. Springer, Cham. https://doi.org/10.1007/978-3-319-43030-0_10
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