Skip to main content

Immune Reactions and Dry Eye After Posterior Lamellar Keratoplasty

  • Chapter
  • First Online:
Current Treatment Options for Fuchs Endothelial Dystrophy

Abstract

Posterior lamellar keratoplasty has been demonstrated to be a successful, increasingly applied surgical method to replace diseased endothelial cells of the human cornea. Potential immune reactions may occur following DMEK or DSAEK with different clinical phenotypes, reasons, and risk factors that accompany graft failure. In addition in this chapter the clinically relevant yet only rudimentarily investigated development of dry eye disease following posterior lamellar keratoplasty is outlined.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Melles GR, Ong TS, Ververs B, van der Wees J. Descemet membrane endothelial keratoplasty (DMEK). Cornea. 2006;25(8):987–90. doi:10.1097/01.ico.0000248385.16896.34 [published Online First: Epub Date].

    Article  PubMed  Google Scholar 

  2. Maier P, Reinhard T, Cursiefen C. Descemet stripping endothelial keratoplasty–rapid recovery of visual acuity. Dtsch Arztebl Int. 2013;110(21):365–71. doi:10.3238/arztebl.2013.0365 [published Online First: Epub Date].

    PubMed  PubMed Central  Google Scholar 

  3. Tourtas T, Laaser K, Bachmann BO, Cursiefen C, Kruse FE. Descemet membrane endothelial keratoplasty versus descemet stripping automated endothelial keratoplasty. Am J Ophthalmol. 2012;153(6):1082–90 e2. doi:10.1016/j.ajo.2011.12.012 [published Online First: Epub Date].

    Article  PubMed  Google Scholar 

  4. Niederkorn JY. Corneal transplantation and immune privilege. Int Rev Immunol. 2013;32(1):57–67. doi:10.3109/08830185.2012.737877 [published Online First: Epub Date].

    Article  CAS  PubMed  Google Scholar 

  5. Bock F, Maruyama K, Regenfuss B, et al. Novel anti(lymph)angiogenic treatment strategies for corneal and ocular surface diseases. Prog Retin Eye Res. 2013;34:89–124. doi:10.1016/j.preteyeres.2013.01.001 [published Online First: Epub Date].

    Article  CAS  PubMed  Google Scholar 

  6. Bachmann B, Taylor RS, Cursiefen C. Corneal neovascularization as a risk factor for graft failure and rejection after keratoplasty: an evidence-based meta-analysis. Ophthalmology. 2010;117(7):1300–5 e7. doi:10.1016/j.ophtha.2010.01.039 [published Online First: Epub Date].

    Article  PubMed  Google Scholar 

  7. Nguyen NX, Seitz B, Martus P, Langenbucher A, Cursiefen C. Long-term topical steroid treatment improves graft survival following normal-risk penetrating keratoplasty. Am J Ophthalmol. 2007;144(2):318–9. doi:10.1016/j.ajo.2007.03.028 [published Online First: Epub Date].

    Article  CAS  PubMed  Google Scholar 

  8. Steven P, Hos D, Heindl LM, Bock F, Cursiefen C. [Immune reactions after DMEK, DSAEK and DALK]. Klin Monbl Augenheilkd. 2013;230(5):494–9. doi:10.1055/s-0032-1328257 [published Online First: Epub Date].

    Article  CAS  PubMed  Google Scholar 

  9. Price MO, Jordan CS, Moore G, Price Jr FW. Graft rejection episodes after Descemet stripping with endothelial keratoplasty: part two: the statistical analysis of probability and risk factors. Br J Ophthalmol. 2009;93(3):391–5. doi:10.1136/bjo.2008.140038 [published Online First: Epub Date].

    Article  CAS  PubMed  Google Scholar 

  10. Yamagami S, Amano S. Role of resident corneal leukocytes and draining cervical lymph nodes in corneal allograft rejection. Cornea. 2003;22(7 Suppl):S61–5.

    Article  PubMed  Google Scholar 

  11. Dapena I, Ham L, Netukova M, van der Wees J, Melles GR. Incidence of early allograft rejection after Descemet membrane endothelial keratoplasty. Cornea. 2011;30(12):1341–5. doi:10.1097/ICO.0b013e31820d8540 [published Online First: Epub Date].

    Article  PubMed  Google Scholar 

  12. Hori J, Streilein JW. Survival in high-risk eyes of epithelium-deprived orthotopic corneal allografts reconstituted in vitro with syngeneic epithelium. Invest Ophthalmol Vis Sci. 2003;44(2):658–64.

    Article  PubMed  Google Scholar 

  13. Hori J, Joyce NC, Streilein JW. Immune privilege and immunogenicity reside among different layers of the mouse cornea. Invest Ophthalmol Vis Sci. 2000;41(10):3032–42.

    CAS  PubMed  Google Scholar 

  14. Chaurasia S, Price Jr FW, Gunderson L, Price MO. Descemet’s membrane endothelial keratoplasty: clinical results of single versus triple procedures (combined with cataract surgery). Ophthalmology. 2014;121(2):454–8. doi:10.1016/j.ophtha.2013.09.032 [published Online First: Epub Date].

    Article  PubMed  Google Scholar 

  15. Jordan CS, Price MO, Trespalacios R, Price Jr FW. Graft rejection episodes after Descemet stripping with endothelial keratoplasty: part one: clinical signs and symptoms. Br J Ophthalmol. 2009;93(3):387–90. doi:10.1136/bjo.2008.140020 [published Online First: Epub Date].

    Article  CAS  PubMed  Google Scholar 

  16. Saelens IE, Bleyen I, Bartels MC, Van Rij G. A posterior khodadoust line in a graft rejection episode after descemet stripping automated endothelial keratoplasty. Cornea. 2011;30(2):245–6. doi:10.1097/ICO.0b013e3181ec9080 [published Online First: Epub Date].

    Article  PubMed  Google Scholar 

  17. Hos D, Heindl LM, Bucher F, Cursiefen C. Evidence of donor corneal endothelial cell migration from immune reactions occurring after descemet membrane endothelial keratoplasty. Cornea. 2014;33(4):331–4. doi:10.1097/ICO.0000000000000054 [published Online First: Epub Date].

    Article  PubMed  Google Scholar 

  18. Khodadoust AA, Silverstein AM. Transplantation and rejection of individual cell layers of the cornea. Invest Ophthalmol. 1969;8(2):180–95.

    CAS  PubMed  Google Scholar 

  19. Sloniecka M, Le Roux S, Zhou Q, Danielson P. Substance P enhances keratocyte migration and neutrophil recruitment through interleukin-8. Mol Pharmacol. 2016;89(2):215–25. doi:10.1124/mol.115.101014 [published Online First: Epub Date].

    Article  CAS  PubMed  Google Scholar 

  20. Paunicka KJ, Mellon J, Robertson D, Petroll M, Brown JR, Niederkorn JY. Severing corneal nerves in one eye induces sympathetic loss of immune privilege and promotes rejection of future corneal allografts placed in either eye. Am J Transplant Official J Am Soc Transplant Am Soc Transplant Surg. 2015;15(6):1490–501. doi:10.1111/ajt.13240 [published Online First: Epub Date].

    Article  CAS  Google Scholar 

  21. Shimazaki J, Iseda A, Satake Y, Shimazaki-Den S. Efficacy and safety of long-term corticosteroid eye drops after penetrating keratoplasty: a prospective, randomized, clinical trial. Ophthalmology. 2012;119(4):668–73. doi:10.1016/j.ophtha.2011.10.016 [published Online First: Epub Date].

    Article  PubMed  Google Scholar 

  22. Ansari R, Myrtus C, Aherrahrou R, Erdmann J, Schweikard A, Huttmann G. Ultrahigh-resolution, high-speed spectral domain optical coherence phase microscopy. Opt Lett. 2014;39(1):45–7. doi:10.1364/OL.39.000045 [published Online First: Epub Date].

    Article  PubMed  Google Scholar 

  23. Gehlsen U, Szaszak M, Gebert A, Koop N, Huttmann G, Steven P. Non-invasive multi-dimensional two-photon microscopy enables optical fingerprinting (TPOF) of immune cells. J Biophotonics. 2015;8(6):466–79. doi:10.1002/jbio.201400036 [published Online First: Epub Date].

    Article  CAS  PubMed  Google Scholar 

  24. Steven P, Muller M, Koop N, Rose C, Huttmann G. Comparison of Cornea Module and DermaInspect for noninvasive imaging of ocular surface pathologies. J Biomed Opt. 2009;14(6):064040. doi:10.1117/1.3275475 [published Online First: Epub Date].

    Article  PubMed  Google Scholar 

  25. Monnereau C, Bruinsma M, Ham L, Baydoun L, Oellerich S, Melles GR. Endothelial cell changes as an indicator for upcoming allograft rejection following descemet membrane endothelial keratoplasty. Am J Ophthalmol. 2014;158(3):485–95. doi:10.1016/j.ajo.2014.05.030 [published Online First: Epub Date].

    Article  CAS  PubMed  Google Scholar 

  26. Stern ME, Gao J, Siemasko KF, Beuerman RW, Pflugfelder SC. The role of the lacrimal functional unit in the pathophysiology of dry eye. Exp Eye Res. 2004;78(3):409–16.

    Article  CAS  PubMed  Google Scholar 

  27. Wilson SE. Laser in situ keratomileusis-induced (presumed) neurotrophic epitheliopathy. Ophthalmology. 2001;108(6):1082–7.

    Article  CAS  PubMed  Google Scholar 

  28. Albietz JM, Lenton LM, McLennan SG. Chronic dry eye and regression after laser in situ keratomileusis for myopia. J Cataract Refract Surg. 2004;30(3):675–84. doi:10.1016/j.jcrs.2003.07.003 [published Online First: Epub Date].

    Article  PubMed  Google Scholar 

  29. Li XM, Hu L, Hu J, Wang W. Investigation of dry eye disease and analysis of the pathogenic factors in patients after cataract surgery. Cornea. 2007;26(9 Suppl 1):S16–20. doi:10.1097/ICO.0b013e31812f67ca [published Online First: Epub Date].

    Article  PubMed  Google Scholar 

  30. Belmonte C, Acosta MC, Gallar J. Neural basis of sensation in intact and injured corneas. Exp Eye Res. 2004;78(3):513–25.

    Article  CAS  PubMed  Google Scholar 

  31. Kuchle M, Cursiefen C, Nguyen NX, et al. Risk factors for corneal allograft rejection: intermediate results of a prospective normal-risk keratoplasty study. Graefes Arch Clin Exp Ophthalmol = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2002;240(4):580. doi:10.1007/s00417-002-0496-5 [published Online First: Epub Date].

    Article  PubMed  Google Scholar 

  32. Bucher F, Hos D, Matthaei M, Steven P, Cursiefen C, Heindl LM. Corneal nerve alterations after Descemet membrane endothelial keratoplasty: an in vivo confocal microscopy study. Cornea. 2014;33(11):1134–9. doi:10.1097/ICO.0000000000000250 [published Online First: Epub Date].

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Philipp Steven MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Steven, P., Siebelmann, S., Hos, D., Bucher, F., Cursiefen, C. (2017). Immune Reactions and Dry Eye After Posterior Lamellar Keratoplasty. In: Cursiefen, C., Jun, A. (eds) Current Treatment Options for Fuchs Endothelial Dystrophy. Springer, Cham. https://doi.org/10.1007/978-3-319-43021-8_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-43021-8_15

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-43019-5

  • Online ISBN: 978-3-319-43021-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics