Skip to main content

Perioperative Management of the Cirrhotic Patient

  • Chapter
  • First Online:
Common Problems in Acute Care Surgery

Abstract

The management of acute surgical pathologies in patients with advanced liver disease can be challenging for even the most experienced surgeon. Appropriate surgical decision making requires an understanding of not only the surgical problem itself, but also the physiologic and anatomic changes that accompany chronic liver disease. As the medical management of patients with advanced liver disease improves, the prevalence of cirrhosis in the general population is increasing. Cirrhotics represent an estimated 0.27 % of the population, approximately 633,323 adults in the USA (Scaglione and Kliethermes, J Clin Gastroenterol 49:690–6, 2015). Accordingly, surgeons can expect to see an increase in the number of cirrhotics requiring acute surgical care and must be prepared to handle these complex patients. This chapter describes issues related to the acutely presenting patient with chronic liver disease. Overviews of the management of cirrhotics presenting for elective non-hepatic surgery are available elsewhere (Mansour et al., Surgery 122:730–5, 1997).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Scaglione S, Kliethermes S. The epidemiology of cirrhosis in the United States: a population-based study. J Clin Gastroenterol. 2015;49(8):690–6.

    Article  PubMed  Google Scholar 

  2. Mansour A, Watson W, Shayani V, et al. Abdominal operations in patients with cirrhosis: still a major surgical challenge. Surgery. 1997;122(4):730–5.

    Article  CAS  PubMed  Google Scholar 

  3. Wong RJ, Aguilar M. Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States. Gastroenterology. 2015;148(3):547–55.

    Article  PubMed  Google Scholar 

  4. Brummel-Ziedins K, Mann KG. Molecular basis of blood coagulation. In: Hoffman R, Benz Jr EJ, Silberstein LE, et al., editors. Hematology: basic principles and practice. 6th ed. Philadelphia: Saunders and Elsevier; 2013. p. 1821–41.

    Google Scholar 

  5. Marks PW. Hematologic manifestations of liver disease. Semin Hematol. 2013;50(3):216–21.

    Article  PubMed  Google Scholar 

  6. Northup PG, Caldwell SH. Coagulation in liver disease: a guide for the clinician. Clin Gastroenterol Hepatol. 2013;11(9):1064–74.

    Article  PubMed  Google Scholar 

  7. Tripodi A, Mannucci PM. The coagulopathy of chronic liver disease. N Engl J Med. 2011;365(2):147–56.

    Article  CAS  PubMed  Google Scholar 

  8. Fisher L, Byrnes E. Prevalence of vitamin K and vitamin D deficiency in patients with hepatobiliary and pancreatic disorders. Nutr Res. 2009;29(9):676–83.

    Article  CAS  PubMed  Google Scholar 

  9. Strople J, Lovell G. Prevalence of subclinical vitamin K deficiency in cholestatic liver disease. J Pediatr Gastroenterol Nutr. 2009;49(1):78–84.

    Article  CAS  PubMed  Google Scholar 

  10. Tripodi A, Primignani M. The coagulopathy of cirrhosis assessed by thromboelastometry and its correlation with conventional coagulation parameters. Thromb Res. 2009;124(1):132–6.

    Article  CAS  PubMed  Google Scholar 

  11. Wang SC, Shieh JF. Thromboelastography-guided transfusion decreases intraoperative blood transfusion during orthotopic liver transplantation: randomized clinical trial. Transplant Proc. 2010;42(7):2590–3.

    Article  PubMed  Google Scholar 

  12. Afdhal N, McHutchison J. Thrombocytopenia associated with chronic liver disease. J Hepatol. 2008;48(6):1000–7.

    Article  CAS  PubMed  Google Scholar 

  13. Hoetzel A, Ryan H. Anesthetic considerations for the patient with liver disease. Curr Opin Anaesthesiol. 2012;25(3):340–7.

    Article  CAS  PubMed  Google Scholar 

  14. Verbeeck RK. Pharmacokinetics and dosage adjustment in patients with hepatic dysfunction. Eur J Clin Pharmacol. 2008;64(12):1147–61.

    Article  CAS  PubMed  Google Scholar 

  15. Figueiredo FA, De Mello PR. Effect of liver cirrhosis on body composition: evidence of significant depletion even in mild disease. J Gastroenterol Hepatol. 2005;20(2):209–16.

    Article  PubMed  Google Scholar 

  16. Kondrup J. Nutrition in end stage liver disease. Best Pract Res Clin Gastroenterol. 2006;20(3):547–60.

    Article  CAS  PubMed  Google Scholar 

  17. Tsiaousi ET, Hatzitolios AI, Trygonis SK, et al. Malnutrition in end stage liver disease: recommendations and nutritional support. J Gastroenterol Hepatol. 2008;23(4):527–33.

    Article  PubMed  Google Scholar 

  18. Schuppan D, Afdhal NH. Liver cirrhosis. Lancet. 2008;371(9615):838–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Bolognesi M, Merkel C. Role of spleen enlargement in cirrhosis with portal hypertension. Dig Liver Dis. 2002;34(2):144–50.

    Article  CAS  PubMed  Google Scholar 

  20. McCormick PA, Murphy KM. Splenomegaly, hypersplenism and coagulation abnormalities in liver disease. Baillieres Best Pract Res Clin Gastroenterol. 2000;14(6):1009–31.

    Article  CAS  PubMed  Google Scholar 

  21. Romero-Gomez M. Hepatic encephalopathy in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure. J Hepatol. 2015;62:437–47.

    Article  CAS  PubMed  Google Scholar 

  22. Butterworth R. Pathogenesis of hepatic encephalopathy and brain edema in acute liver failure. J Clin Exp Hepatol. 2015;5(S1):S96–103.

    Article  PubMed  Google Scholar 

  23. Gonwa TA, Wadei HM. Kidney disease in the setting of liver failure: core curriculum 2013. Am J Kidney Dis. 2013;62(6):1198–212.

    Article  PubMed  Google Scholar 

  24. Bozanich NK, Kwo PY. Renal insufficiency in the patient with chronic liver disease. Clin Liver Dis. 2015;19(1):45–56.

    Article  PubMed  Google Scholar 

  25. Pall A. Pathophysiological and clinical approach to cirrhotic cardiomyopathy. J Gastrointestin Liver Dis. 2014;23(3):301–10.

    PubMed  Google Scholar 

  26. Bhangui P. Assessment of risk for non-hepatic surgery in cirrhotic patients. J Hepatol. 2012;57(4):874–84.

    Article  PubMed  Google Scholar 

  27. Geode BD. Morbidity and mortality related to non-hepatic surgery in patients with liver cirrhosis: a systematic review. Best Pract Res Clin Gastroenterol. 2012;26(1):47–59.

    Article  Google Scholar 

  28. Befeler AS, Palmer DE, Hoffman M, et al. The safety of intra-abdominal surgery in patients with cirrhosis: model for end-stage liver disease score is superior to Child-Turcotte-Pugh classification in predicting outcome. Arch Surg. 2005;140(7):650–4. Discussion 655.

    Article  PubMed  Google Scholar 

  29. Dundar HZ, Yılmazlar T. Management of hepatorenal syndrome. World J Nephrol. 2015;4(2):277–86.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Eker HH. A prospective study on elective umbilical hernia repair in patients with liver cirrhosis and ascites. Surgery. 2011;150(3):542–6.

    Article  PubMed  Google Scholar 

  31. Marsman HA. Management in patients with liver cirrhosis and an umbilical hernia. Surgery. 2008;143(5):695.

    Article  PubMed  Google Scholar 

  32. Ammar SA. Management of complicated umbilical hernias in cirrhotic patients using permanent mesh: randomized clinical trial. Hernia. 2010;14(1):35–8.

    Article  CAS  PubMed  Google Scholar 

  33. Flood FB. Spontaneous perforation of the umbilicus in Laennec's cirrhosis with massive ascites. N Engl J Med. 1961;264:72–4.

    Article  CAS  PubMed  Google Scholar 

  34. Acalovschi M. Gallstones in patients with liver cirrhosis: incidence, etiology, clinical and therapeutical aspects. World J Gastroenterol. 2014;20(23):7277–85.

    Article  PubMed  PubMed Central  Google Scholar 

  35. Yao Z, Hu K. Delayed laparoscopic cholecystectomy is safe and effective for acute severe calculous cholecystitis in patients with advanced cirrhosis: a single center experience. Gastroenterol Res Pract. 2014;2014:178908.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Morrison CA. The effects of cirrhosis on trauma outcomes: an analysis of the National Trauma Data Bank. J Surg Res. 2008.04.034.

    Google Scholar 

  37. Talving P. The impact of liver cirrhosis on outcomes in trauma patients: a prospective study. J Trauma Acute Care Surg. 2013;75(4):699–703.

    Article  PubMed  Google Scholar 

  38. Christmas AB. Cirrhosis and trauma: a deadly duo. Am Surg. 2005;71(12):996–1000.

    PubMed  Google Scholar 

  39. Barmparas G, Cooper Z. The effect of cirrhosis on the risk for failure of nonoperative management of blunt liver injuries. Surgery. 2015;pii: S0039-6060(15)00540-1.

    Google Scholar 

  40. Bugaev N, Breeze JL. Management and outcome of patients with blunt splenic injury and preexisting liver cirrhosis. J Trauma Acute Care Surg. 2014;76(6):1354–61.

    Article  PubMed  Google Scholar 

  41. Fang JF, Chen RJ. Liver cirrhosis: an unfavorable factor for nonoperative management of blunt splenic injury. J Trauma. 2003;54(6):1131–6.

    Article  PubMed  Google Scholar 

  42. Cook MR, Fair KA. Cirrhosis increases mortality and splenectomy rates following splenic injury. Am J Surg. 2015;209(5):841–7.

    Article  PubMed  Google Scholar 

  43. Akriviadis EA, Runyon BA. Utility of an algorithm in differentiating spontaneous from secondary bacterial peritonitis. Gastroenterology. 1990;98(1):127.

    Article  CAS  PubMed  Google Scholar 

  44. Garrison RN, Cryer HM, Howard DA, Polk Jr HC. Clarification of risk factors for abdominal operations in patients with hepatic cirrhosis. Ann Surg. 1984;199(6):648.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Chan A, Dai J, Chok K, Cheung TT, Lo CM. Prognostic influence of spontaneous tumor rupture on hepatocellular carcinoma after interval hepatectomy. Surgery. 2015 (In Press).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mark J. Hobeika .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Harmouch, M.A., Hobeika, M.J. (2017). Perioperative Management of the Cirrhotic Patient. In: Moore, L., Todd, S. (eds) Common Problems in Acute Care Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-42792-8_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-42792-8_4

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42790-4

  • Online ISBN: 978-3-319-42792-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics