The Subthalamic Nucleus and Reward-Related Processes
Considered for a long time a simple relay structure on the so-called indirect pathway of the motor loop within the basal ganglia, the subthalamic nucleus is now considered a critical node in the reward circuitry. This chapter discusses recent evidence for this role in both the animal and clinical literature. There is converging recent evidence to suggest that inactivating this structure could represent an interesting strategy for the treatment of certain forms of reward-related dysfunctions, including drug addiction.
KeywordsSubthalamic nucleus Reward Drug addiction
The author’s work reported in this chapter has been supported by grants from the Centre National de la Recherche Scientifique (CNRS), Aix-Marseille Université, the Agence Nationale pour la Recherche (ANR-09-MNPS-028-01 and ANR 2010-NEUR-005-01 in the framework of the ERA-Net NEURON and projet “investissement d’avenir” A*MIDEX with reference ANR-11-IDEX-0001-02), the IREB (Institut de Recherches Scientifiques sur les Boissons), and Fondation pour le Recherche Médicale (FRM, DPA20140629789).
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