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Gastrointestinal Stromal Tumors pp 17–43Cite as

Surgical Pathology of Gastrointestinal Stromal Tumors: Correlation with Clinical and Molecular Subtypes

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Abstract

Advances in our understanding of the pathobiology of gastrointestinal stromal tumor (GIST) have led to an increasingly refined classification of a molecularly heterogeneous group of tumors and the discovery of clinicopathologically distinct subtypes with critical implications for therapeutics, prognosis, and genetic counseling. Histomorphology, immunohistochemistry, and mutational analysis continue to play an exceedingly important role, not only in diagnosis, but also in the clinical management and achievement of optimal outcomes in patients with GIST. This chapter reviews diagnostic advances and the key histologic features of GIST, in conjunction with clinical and molecular correlates.

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Authors and Affiliations

  1. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Odise Cenaj MD, Vickie Y. Jo MD & Leona A. Doyle MD

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  1. Odise Cenaj MD
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  2. Vickie Y. Jo MD
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  3. Leona A. Doyle MD
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Correspondence to Leona A. Doyle MD .

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  1. School of Medicine, University of Louisville, Louisville, Kentucky, USA

    Charles R. Scoggins

  2. Brigham & Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA

    Chandrajit P. Raut

  3. Harvard Medical School, Boston, Massachusetts, USA

    John T. Mullen

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Cenaj, O., Jo, V.Y., Doyle, L.A. (2017). Surgical Pathology of Gastrointestinal Stromal Tumors: Correlation with Clinical and Molecular Subtypes. In: Scoggins, C., Raut, C., Mullen, J. (eds) Gastrointestinal Stromal Tumors. Springer, Cham. https://doi.org/10.1007/978-3-319-42632-7_3

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  • DOI: https://doi.org/10.1007/978-3-319-42632-7_3

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