Skip to main content

Minimally Invasive Approaches to Gastrointestinal Stromal Tumors (GISTs)

  • Chapter
  • First Online:
Gastrointestinal Stromal Tumors

Abstract

The concept and proof of concept of minimally invasive surgical techniques began with the introduction of laparoscopic cholecystectomy in 1987. Since then, laparoscopy has improved patient outcomes and transitioned through all surgical specialties, including general surgery thoracic, vascular, gynecology, and urology. Minimally invasive surgery has evolved since its creation due to improvements in instruments, visualization, hemostatsis, robotics, the ability to combine laparoscopy with intraoperative endoscopy, and the wide availability of these technologies to maximize favorable outcomes. The application of minimally invasive surgical techniques to the treatment of gastrointestinal stromal tumors (GISTs) has been extensively studied, and the general conclusion is that laparoscopic removal of GIST in most patients is associated with a shorter hospital stay and comparable long-term oncologic outcomes compared to open resection [1–8]. However, as with any operation for GIST, the adherence to oncologic surgical practices, including prevention of tumor spillage and appropriate resection, must be considered before deciding on a minimally invasive resection [1].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Nishimura J, Nakajima K, Omori T, Takahashi T, Nishitani A, Ito T, Nishida T. Surgical strategy for gastric gastrointestinal stromal tumors: laparoscopic vs. open resection. Surg Endosc. 2007;21(6):875–8. doi:10.1007/s00464-006-9065-z.

    Article  PubMed  Google Scholar 

  2. Pelletier JS, Gill RS, Gazala S, Karmali S. A systematic review and meta-analysis of open vs. Laparoscopic resection of gastric gastrointestinal stromal tumors. J Clin Med Res. 2015;7(5):289–96. doi:10.14740/jocmr1547w.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Liao CH, Yeh CN, Wang SY, Fu CY, Tsai CY, Liu YY, Cheng CT, Yeh TS. Surgical option for intestinal gastrointestinal stromal tumors--perioperative and oncological outcomes of laparoscopic surgery. Anticancer Res. 2015;35(2):1033–40.

    PubMed  Google Scholar 

  4. Chen QL, Pan Y, Cai JQ, Wu D, Chen K, Mou YP. Laparoscopic versus open resection for gastric gastrointestinal stromal tumors: an updated systematic review and meta-analysis. World J Surg Oncol. 2014;12:206. doi:10.1186/1477-7819-12-206.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Bischof DA, Kim Y, Dodson R, Carolina Jimenez M, Behman R, Cocieru A, Blazer 3rd DG, Fisher SB, Squires 3rd MH, Kooby DA, Maithel SK, Groeschl RT, Clark Gamblin T, Bauer TW, Karanicolas PJ, Law C, Quereshy FA, Pawlik TM. Open versus minimally invasive resection of gastric GIST: a multi-institutional analysis of short- and long-term outcomes. Ann Surg Oncol. 2014;21(9):2941–8. doi:10.1245/s10434-014-3733-3.

    Article  PubMed  Google Scholar 

  6. Fisher SB, Kim SC, Kooby DA, Cardona K, Russell MC, Delman KA, Staley 3rd CA, Maithel SK. Gastrointestinal stromal tumors: a single institution experience of 176 surgical patients. Am Surg. 2013;79(7):657–65.

    PubMed  Google Scholar 

  7. Tabrizian P, Nguyen SQ, Divino CM. Laparoscopic management and longterm outcomes of gastrointestinal stromal tumors. J Am Coll Surg. 2009;208(1):80–6. doi:10.1016/j.jamcollsurg.2008.08.028.

    Article  PubMed  Google Scholar 

  8. Melstrom LG, Phillips JD, Bentrem DJ, Wayne JD. Laparoscopic versus open resection of gastric gastrointestinal stromal tumors. Am J Clin Oncol. 2012;35(5):451–4. doi:10.1097/COC.0b013e31821954a7.

    Article  PubMed  Google Scholar 

  9. Walsh RM, Heniford BT. Laparoendoscopic treatment of gastric stromal tumors. Semin Laparosc Surg. 2001;8(3):189–94.

    Article  CAS  PubMed  Google Scholar 

  10. Novitsky YW, Kercher KW, Sing RF, Heniford BT. Long-term outcomes of laparoscopic resection of gastric gastrointestinal stromal tumors. Ann Surg. 2006;243(6):738–45. doi:10.1097/01.sla.0000219739.11758.27; discussion 745–37.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Kim HH. Endoscopic treatment for gastrointestinal stromal tumor: advantages and hurdles. World J Gastroint Endoscopy. 2015;7(3):192–205. doi:10.4253/wjge.v7.i3.192.

    Article  Google Scholar 

  12. Cheng HL, Lee WJ, Lai IR, Yuan RH, Yu SC. Laparoscopic wedge resection of benign gastric tumor. Hepatogastroenterology. 1999;46(27):2100–4.

    CAS  PubMed  Google Scholar 

  13. Kimata M, Kubota T, Otani Y, Ohgami M, Ishikawa Y, Yokoyama T, Issiki S, Abe S, Egawa T, Tokuyama J, Wada N, Kumai K, Kitajima M, Mukai M. Gastrointestinal stromal tumors treated by laparoscopic surgery: report of three cases. Surg Today. 2000;30(2):177–80.

    Article  CAS  PubMed  Google Scholar 

  14. Matsui H, Uyama I, Fujita J, Komori Y, Sugioka A, Hasumi A. Gastrointestinal stromal tumor of the stomach successfully treated by laparoscopic proximal gastrectomy with jejunal interposition. Surg Laparosc Endosc Percutan Tech. 2000;10(4):239–42.

    Article  CAS  PubMed  Google Scholar 

  15. Tagaya N, Mikami H, Kogure H, Kubota K, Hosoya Y, Nagai H. Laparoscopic intragastric stapled resection of gastric submucosal tumors located near the esophagogastric junction. Surg Endosc. 2002;16(1):177–9. doi:10.1007/s004640080158.

    Article  CAS  PubMed  Google Scholar 

  16. Matthews BD, Walsh RM, Kercher KW, Sing RF, Pratt BL, Answini GA, Heniford BT. Laparoscopic vs open resection of gastric stromal tumors. Surg Endosc. 2002;16(5):803–7. doi:10.1007/s00464-001-8319-z.

    Article  CAS  PubMed  Google Scholar 

  17. Matthews BD, Joels CS, Kercher KW, Heniford BT. Gastrointestinal stromal tumors of the stomach. Minerva Chir. 2004;59(3):219–31.

    CAS  PubMed  Google Scholar 

  18. Heniford BT, Arca MJ, Walsh RM. The mini-laparoscopic intragastric resection of a gastroesophageal stromal tumor: a novel approach. Surg Laparosc Endosc Percutan Tech. 2000;10(2):82–5.

    Article  CAS  PubMed  Google Scholar 

  19. Walsh RM, Ponsky J, Brody F, Matthews BD, Heniford BT. Combined endoscopic/laparoscopic intragastric resection of gastric stromal tumors. J Gastroint Surg Off J Soc Surg Alimentary Tract. 2003;7(3):386–92.

    Article  Google Scholar 

  20. Nguyen NT, Jim J, Nguyen A, Lee J, Chang K. Laparoscopic resection of gastric stromal tumor: a tailored approach. Am Surg. 2003;69(11):946–50.

    PubMed  Google Scholar 

  21. Heinrich MC, Corless CL. Gastric GI stromal tumors (GISTs): the role of surgery in the era of targeted therapy. J Surg Oncol. 2005;90(3):195–207. doi:10.1002/jso.20230; discussion 207.

    Article  PubMed  Google Scholar 

  22. Demetri GD, Benjamin R, Blanke CD, Choi H, Corless C, DeMatteo RP, Eisenberg BL, Fletcher CD, Maki RG, Rubin BP, Van den Abbeele AD, von Mehren M, Force NGT. NCCN Task Force report: optimal management of patients with gastrointestinal stromal tumor (GIST)–expansion and update of NCCN clinical practice guidelines. J Natl Compr Cancer Network JNCCN. 2004;2 Suppl 1:S1–26; quiz 27–30.

    Google Scholar 

  23. De Vogelaere K, Van Loo I, Peters O, Hoorens A, Haentjens P, Delvaux G. Laparoscopic resection of gastric gastrointestinal stromal tumors (GIST) is safe and effective, irrespective of tumor size. Surg Endosc. 2012;26(8):2339–45. doi:10.1007/s00464-012-2186-7.

    Article  PubMed  Google Scholar 

  24. Mochizuki Y, Kodera Y, Fujiwara M, Ito S, Yamamura Y, Sawaki A, Yamao K, Kato T. Laparoscopic wedge resection for gastrointestinal stromal tumors of the stomach: initial experience. Surg Today. 2006;36(4):341–7. doi:10.1007/s00595-005-3164-7.

    Article  PubMed  Google Scholar 

  25. Nakamori M, Iwahashi M, Nakamura M, Tabuse K, Mori K, Taniguchi K, Aoki Y, Yamaue H. Laparoscopic resection for gastrointestinal stromal tumors of the stomach. Am J Surg. 2008;196(3):425–9. doi:10.1016/j.amjsurg.2007.10.012.

    Article  PubMed  Google Scholar 

  26. Demetri GD, von Mehren M, Antonescu CR, DeMatteo RP, Ganjoo KN, Maki RG, Pisters PW, Raut CP, Riedel RF, Schuetze S, Sundar HM, Trent JC, Wayne JD. NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors. J Natl Compr Cancer Network JNCCN. 2010;8 Suppl 2:S1–41; quiz S42–44.

    CAS  Google Scholar 

  27. Appleman HD, Helwig EB. Gastric epithelioid leiomyoma and leiomyosarcoma (leiomyoblastoma). Cancer. 1976;38(2):708–28.

    Article  CAS  PubMed  Google Scholar 

  28. DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann Surg. 2000;231(1):51–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Ohashi S. Laparoscopic intraluminal (intragastric) surgery for early gastric cancer. A new concept in laparoscopic surgery. Surg Endosc. 1995;9(2):169–71.

    Article  CAS  PubMed  Google Scholar 

  30. Cuschieri A. Laparoscopic gastric resection. Surg Clin North Am. 2000;80(4):1269–84. viii.

    Article  CAS  PubMed  Google Scholar 

  31. Goh PM, Alponat A, Mak K, Kum CK. Early international results of laparoscopic gastrectomies. Surg Endosc. 1997;11(6):650–2.

    Article  CAS  PubMed  Google Scholar 

  32. Gersin KS, Heniford BT, Baradi H, Ponsky JL. Laparoendoscopic excision of a duodenal mass. Endoscopy. 1999;31(5):398–400. doi:10.1055/s-1999-25.

    Article  CAS  PubMed  Google Scholar 

  33. Zheng L, Ding W, Zhou D, Lu L, Yao L. Laparoscopic versus open resection for gastric gastrointestinal stromal tumors: a meta-analysis. Am Surg. 2014;80(1):48–56.

    PubMed  Google Scholar 

  34. Koh YX, Chok AY, Zheng HL, Tan CS, Chow PK, Wong WK, Goh BK. A systematic review and meta-analysis comparing laparoscopic versus open gastric resections for gastrointestinal stromal tumors of the stomach. Ann Surg Oncol. 2013;20(11):3549–60. doi:10.1245/s10434-013-3051-1.

    Article  PubMed  Google Scholar 

  35. Karakousis GC, Singer S, Zheng J, Gonen M, Coit D, DeMatteo RP, Strong VE. Laparoscopic versus open gastric resections for primary gastrointestinal stromal tumors (GISTs): a size-matched comparison. Ann Surg Oncol. 2011;18(6):1599–605. doi:10.1245/s10434-010-1517-y.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Schwameis K, Fochtmann A, Schwameis M, Asari R, Schur S, Kostler W, Birner P, Ba-Ssalamah A, Zacherl J, Wrba F, Brodowicz T, Schoppmann SF. Surgical treatment of GIST–an institutional experience of a high-volume center. Int J Surg (London, England). 2013;11(9):801–6. doi:10.1016/j.ijsu.2013.08.016.

    Article  Google Scholar 

  37. Kato M, Nakajima K, Nishida T, Yamasaki M, Nishida T, Tsutsui S, Ogiyama H, Yamamoto S, Yamada T, Mori M, Doki Y, Hayashi N. Local resection by combined laparoendoscopic surgery for duodenal gastrointestinal stromal tumor. Diagn Therap Endosc. 2011;2011:645609. doi:10.1155/2011/645609.

    Google Scholar 

  38. Singaporewalla RM, Baladas GH, Lee TD. Laparoendoscopic removal of a benign gastric stromal tumor at the cardia. JSLS J Soc Laparoendosc Surg Soc Laparoendosc Surg. 2006;10(1):117–21.

    Google Scholar 

  39. Hirano Y, Watanabe T, Uchida T, Yoshida S, Kato H, Hosokawa O. Laparoendoscopic single site partial resection of the stomach for gastrointestinal stromal tumor. Surg Laparosc Endosc Percutan Tech. 2010;20(4):262–4. doi:10.1097/SLE.0b013e3181e36a5b.

    Article  PubMed  Google Scholar 

  40. Henckens T, Van de Putte D, Van Renterghem K, Ceelen W, Pattyn P, Van Nieuwenhove Y. Laparoendoscopic single-site gastrectomy for a gastric GIST using double-bended instruments. J Laparoendosc Adv Surg Tech A. 2010;20(5):469–71. doi:10.1089/lap.2009.0391.

    Article  PubMed  Google Scholar 

  41. Zhou PH, Yao LQ, Qin XY, Cai MY, Xu MD, Zhong YS, Chen WF, Zhang YQ, Qin WZ, Hu JW, Liu JZ. Endoscopic full-thickness resection without laparoscopic assistance for gastric submucosal tumors originated from the muscularis propria. Surg Endosc. 2011;25(9):2926–31. doi:10.1007/s00464-011-1644-y.

    Article  PubMed  Google Scholar 

  42. Huang LY, Cui J, Wu CR, Zhang B, Jiang LX, Xian XS, Lin SJ, Xu N, Cao XL, Wang ZH. Endoscopic full-thickness resection and laparoscopic surgery for treatment of gastric stromal tumors. World J Gastroenterol WJG. 2014;20(25):8253–9. doi:10.3748/wjg.v20.i25.8253.

    Article  PubMed  Google Scholar 

  43. Wang L, Ren W, Fan CQ, Li YH, Zhang X, Yu J, Zhao GC, Zhao XY. Full-thickness endoscopic resection of nonintracavitary gastric stromal tumors: a novel approach. Surg Endosc. 2011;25(2):641–7. doi:10.1007/s00464-010-1189-5.

    Article  PubMed  Google Scholar 

  44. Buchs NC, Bucher P, Pugin F, Hagen ME, Morel P. Robot-assisted oncologic resection for large gastric gastrointestinal stromal tumor: a preliminary case series. J Laparoendosc Adv Surg Tech A. 2010;20(5):411–5. doi:10.1089/lap.2009.0385.

    Article  PubMed  Google Scholar 

  45. Moriyama H, Ishikawa N, Kawaguchi M, Hirose K, Watanabe G. Robot-assisted laparoscopic resection for gastric gastrointestinal stromal tumor. Surg Laparosc Endosc Percutan Tech. 2012;22(3):e155–6. doi:10.1097/SLE.0b013e3182491ff6.

    Article  PubMed  Google Scholar 

  46. Ortiz-Oshiro E, Exposito PB, Sierra JM, Gonzalez JD, Barbosa DS, Fernandez-Represa JA. Laparoscopic and robotic distal gastrectomy for gastrointestinal stromal tumour: case report. Int J Med Robot Computer Aassist Surg MRCAS. 2012;8(4):491–5. doi:10.1002/rcs.1456.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to B. Todd Heniford MD, FACS .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Cox, T.C., Augenstein, V.A., Schell, S., Heniford, B.T. (2017). Minimally Invasive Approaches to Gastrointestinal Stromal Tumors (GISTs). In: Scoggins, C., Raut, C., Mullen, J. (eds) Gastrointestinal Stromal Tumors. Springer, Cham. https://doi.org/10.1007/978-3-319-42632-7_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-42632-7_10

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-42630-3

  • Online ISBN: 978-3-319-42632-7

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics