Skip to main content
SpringerLink
Log in
Book cover

Formulating Poorly Water Soluble Drugs pp 691–740Cite as

Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs

  • Chapter
  • First Online:

  • 3385 Accesses

Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series ((AAPS,volume 22))

Abstract

The need for novel processes and formulation-based techniques to enhance the solubility of poorly water-soluble drugs has increased substantially in recent years. This is primarily due to the limitations of traditional techniques such as physical and chemical stability of the drug substance or the need for toxic solvents that some techniques require. Alternative solubility-enhancement techniques have emerged in recent years to mitigate issues such as these. The purpose of this chapter is to describe emerging technologies for solubility enhancement, allowing the reader to gain an understanding of their utility.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Ahuja N, Katare OP, Singh B (2007) Studies on dissolution enhancement and mathematical modeling of drug release of a poorly water-soluble drug using water-soluble carriers. Eur J Pharm Biopharm 65(1):26–38

    Article  CAS  PubMed  Google Scholar 

  • Allesø M, Chieng N, Rehder S, Rantanen J, Rades T, Aaltonen J (2009) Enhanced dissolution rate and synchronized release of drugs in binary systems through formulation: amorphous naproxen–cimetidine mixtures prepared by mechanical activation. J Control Release 136(1):45–53

    Article  PubMed  CAS  Google Scholar 

  • Alomari M, Mohamed FH, Basit AW, Gaisford S (2015) Personalised dosing: printing a dose of one’s own medicine. Int J Pharm 494(2):568–577. doi:10.1016/j.ijpharm.2014.12.006

    Article  CAS  PubMed  Google Scholar 

  • Amritha Rammohan B, Tayal L, Kumar A, Sivakumar S, Sharma A (2013) Fabrication of polymer-modified monodisperse mesoporous carbon particles by template-based approach for drug delivery. RSC Adv 3(6):2008–2016. doi:10.1039/C2RA22261B

    Article  Google Scholar 

  • Andersson J, Rosenholm J, Areva S, Lindén M (2004) Influences of material characteristics on ibuprofen drug loading and release profiles from ordered micro-and mesoporous silica matrices. Chem Mater 16(21):4160–4167

    Article  CAS  Google Scholar 

  • Baldoni JM, Ignatious F, Inventors (2001) Electrospun pharmaceutical compositions patent WO2001054667

    Google Scholar 

  • Balogh A, Drávavölgyi G, Faragó K, Farkas A, Vigh T, Sóti PL et al (2014) Plasticized drug-loaded melt electrospun polymer mats: characterization, thermal degradation, and release kinetics. J Pharm Sci 103(4):1278–1287. doi:10.1002/jps.23904

    Article  CAS  PubMed  Google Scholar 

  • Balogh A, Farkas B, Faragó K, Farkas A, Wagner I, Van Assche I et al (2015) Melt-blown and electrospun drug-loaded polymer fiber mats for dissolution enhancement: a comparative study. J Pharm Sci 104(5):1767–1776. doi:10.1002/jps.24399

    Article  CAS  PubMed  Google Scholar 

  • Bastin RJ, Bowker MJ, Slater BJ (2000) Salt selection and optimisation procedures for pharmaceutical new chemical entities. Org Process Res Dev 4(5):427–435. doi:10.1021/op000018u

    Article  CAS  Google Scholar 

  • Bennett RC, Brough C, Miller DA, O’Donnell KP, Keen JM, Hughey JR et al (2013) Preparation of amorphous solid dispersions by rotary evaporation and KinetiSol dispersing: approaches to enhance solubility of a poorly water-soluble gum extract. Drug Dev Ind Pharm 41(3):382–397

    Article  PubMed  CAS  Google Scholar 

  • Bernardos A, Aznar E, Coll C, Martínez-Mañez R, Barat JM, Marcos MD et al (2008) Controlled release of vitamin B 2 using mesoporous materials functionalized with amine-bearing gate-like scaffoldings. J Control Release 131(3):181–189

    Article  CAS  PubMed  Google Scholar 

  • Bhardwaj N, Kundu SC (2010) Electrospinning: a fascinating fiber fabrication technique. Biotechnol Adv 28(3):325–347. doi:10.1016/j.biotechadv.2010.01.004

    Article  CAS  PubMed  Google Scholar 

  • Bhutia YD, Babu E, Ramachandran S, Ganapathy V (2015) Amino acid transporters in cancer and their relevance to “Glutamine Addiction”: novel targets for the design of a new class of anticancer drugs. Cancer Res 75(9):1782–1788. doi:10.1158/0008-5472.can-14-3745

    Article  CAS  PubMed  Google Scholar 

  • Bimbo LM, Mäkilä E, Laaksonen T, Lehto V-P, Salonen J, Hirvonen J et al (2011) Drug permeation across intestinal epithelial cells using porous silicon nanoparticles. Biomaterials 32(10):2625–2633

    Article  CAS  PubMed  Google Scholar 

  • Boehm RD, Miller PR, Hayes SL, Monteiro-Riviere NA, Narayan RJ (2011) Modification of microneedles using inkjet printing. AIP Adv 1(2):22139. doi:10.1063/1.3602461

    Article  CAS  PubMed  Google Scholar 

  • Bradbury MS, Pauliah M, Wiesner U (2015) Ultrasmall fluorescent silica nanoparticles as intraoperative imaging tools for cancer diagnosis and treatment. In: Fong Y, Giulianotti PC, Lewis J, Groot Koerkamp B, Reiner T (eds) Imaging and visualization in the modern operating room. Springer, New York, pp 167–179

    Chapter  Google Scholar 

  • Breitenbach J (2002) Melt extrusion: from process to drug delivery technology. Eur J Pharm Biopharm 54(2):107–117

    Article  CAS  PubMed  Google Scholar 

  • Brough C, Miller D, Keen J, Kucera S, Lubda D, Williams R III (2015) Use of polyvinyl alcohol as a solubility-enhancing polymer for poorly water soluble drug delivery (part 1). AAPS PharmSciTech 17(1):1–13. doi:10.1208/s12249-015-0458-y

    Google Scholar 

  • Campbell I, Bourell D, Gibson I (2012) Additive manufacturing: rapid prototyping comes of age. Rapid Prototyping J 18(4):255–258. doi:10.1108/13552541211231563

    Article  Google Scholar 

  • Capone C, Di Landro L, Inzoli F, Penco M, Sartore L (2007) Thermal and mechanical degradation during polymer extrusion processing. Polym Eng Sci 47(11):1813–1819

    Article  CAS  Google Scholar 

  • Chieng N, Aaltonen J, Saville D, Rades T (2009) Physical characterization and stability of amorphous indomethacin and ranitidine hydrochloride binary systems prepared by mechanical activation. Eur J Pharm Biopharm 71(1):47–54

    Article  CAS  PubMed  Google Scholar 

  • Chiou WL, Riegelman S (1971) Pharmaceutical applications of solid dispersion systems. J Pharm Sci 60(9):1281–1302

    Article  CAS  PubMed  Google Scholar 

  • Chua CK, Leong KF, An J (2014) Introduction to rapid prototyping of biomaterials. In: Narayan R (ed) Rapid prototyping of biomaterials. Woodhead Publishing, Philadelphia, pp 1–15

    Chapter  Google Scholar 

  • Coppens K, Hall M, Larsen P, Mitchell S, Nguyen P, Read M et al (eds) (2004) Thermal and rheological evaluation of pharmaceutical excipients for hot melt extrusion. AAPS annual meeting and exposition, Baltimore, MD

    Google Scholar 

  • Crowley MM, Zhang F, Koleng JJ, McGinity JW (2002) Stability of polyethylene oxide in matrix tablets prepared by hot-melt extrusion. Biomaterials 23(21):4241–4248. doi:10.1016/S0142-9612(02)00187-4

    Article  CAS  PubMed  Google Scholar 

  • Crowley MM, Zhang F, Repka MA, Thumma S, Upadhye SB, Kumar Battu S et al (2007) Pharmaceutical applications of hot-melt extrusion: part I. Drug Dev Ind Pharm 33(9):909–926

    Article  CAS  PubMed  Google Scholar 

  • Daly R, Harrington TS, Martin GD, Hutchings IM (2015) Inkjet printing for pharmaceutics—a review of research and manufacturing. Int J Pharm 494(2):554–567. doi:10.1016/j.ijpharm.2015.03.017

    Article  CAS  PubMed  Google Scholar 

  • De Jaeghere W, De Beer T, Van Bocxlaer J, Remon JP, Vervaet C (2015) Hot-melt extrusion of polyvinyl alcohol for oral immediate release applications. Int J Pharm 492(1–2):1–9. doi:10.1016/j.ijpharm.2015.07.009

    Article  PubMed  CAS  Google Scholar 

  • Deitzel J, Kleinmeyer J, Harris D, Tan NB (2001) The effect of processing variables on the morphology of electrospun nanofibers and textiles. Polymer 42(1):261–272

    Article  CAS  Google Scholar 

  • Dengale SJ, Ranjan OP, Hussen SS, Krishna BSM, Musmade PB, Gautham Shenoy G et al (2014) Preparation and characterization of co-amorphous Ritonavir–Indomethacin systems by solvent evaporation technique: improved dissolution behavior and physical stability without evidence of intermolecular interactions. Eur J Pharm Sci 62:57–64. doi:10.1016/j.ejps.2014.05.015

    Article  CAS  PubMed  Google Scholar 

  • Dimov SS (2001) Rapid manufacturing: the technologies and applications of rapid prototyping and rapid tooling. Springer, London

    Google Scholar 

  • DiNunzio JC, Brough C, Brown A, Williams RO, McGinity JW (2008). Fusion processing of itraconazole and griseofulvin solid dispersions by a novel high energy manufacturing technology—KinetiSol® dispersing. American Association of Pharmaceutical Scientists Annual Meeting; Atlanta, Georgia

    Google Scholar 

  • DiNunzio JC, Brough C, Hughey JR, Miller DA, Williams RO III, McGinity JW (2010a) Fusion production of solid dispersions containing a heat-sensitive active ingredient by hot melt extrusion and Kinetisol® dispersing. Eur J Pharm Biopharm 74(2):340–351. doi:10.1016/j.ejpb.2009.09.007

    Article  CAS  PubMed  Google Scholar 

  • DiNunzio JC, Brough C, Miller DA, Williams RO III, McGinity JW (2010b) Applications of KinetiSol® Dispersing for the production of plasticizer free amorphous solid dispersions. Eur J Pharm Sci 40(3):179–187. doi:10.1016/j.ejps.2010.03.002

    Article  CAS  PubMed  Google Scholar 

  • DiNunzio JC, Brough C, Miller DA, Williams RO, McGinity JW (2010c) Fusion processing of itraconazole solid dispersions by Kinetisol® dispersing: a comparative study to hot melt extrusion. J Pharm Sci 99(3):1239–1253. doi:10.1002/jps.21893

    Article  CAS  PubMed  Google Scholar 

  • DiNunzio JC, Hughey JR, Brough C, Miller DA, Williams RO III, McGinity JW (2010d) Production of advanced solid dispersions for enhanced bioavailability of itraconazole using KinetiSol® dispersing. Drug Dev Ind Pharm 36(9):1064–1078

    Article  CAS  PubMed  Google Scholar 

  • Doshi J, Reneker DH (eds) (1993) Electrospinning process and applications of electrospun fibers. Industry Applications Society annual meeting. Conference record of the 1993 IEEE, IEEE

    Google Scholar 

  • Dutta P, Dey J (2011) Drug solubilization by amino acid based polymeric nanoparticles: characterization and biocompatibility studies. Int J Pharm 421(2):353–363. doi:10.1016/j.ijpharm.2011.10.011

    Article  CAS  PubMed  Google Scholar 

  • El’Darov E, Mamedov F, Gol’Dberg V, Zaikov G (1996) A kinetic model of polymer degradation during extrusion. Polym Degrad Stab 51(3):271–279

    Article  Google Scholar 

  • Ewing AV, Biggart GD, Hale CR, Clarke GS, Kazarian SG (2015) Comparison of pharmaceutical formulations: ATR-FTIR spectroscopic imaging to study drug-carrier interactions. Int J Pharm 495(1):112–121. doi:10.1016/j.ijpharm.2015.08.068

    Article  CAS  PubMed  Google Scholar 

  • Fadeel B, Garcia-Bennett AE (2010) Better safe than sorry: understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications. Adv Drug Deliv Rev 62(3):362–374. doi:10.1016/j.addr.2009.11.008

    Article  CAS  PubMed  Google Scholar 

  • Follonier N, Doelker E, Cole ET (1994) Evaluation of hot-melt extrusion as a new technique for the production of polymer-based pellets for sustained release capsules containing high loadings of freely soluble drugs. Drug Dev Ind Pharm 20(8):1323–1339

    Article  CAS  Google Scholar 

  • Fousteris E, Tarantili PA, Karavas E, Bikiaris D (2013) Poly (vinyl pyrrolidone)–poloxamer-188 solid dispersions prepared by hot melt extrusion. J Therm Anal Calorim 113(3):1037–1047

    Article  CAS  Google Scholar 

  • Fukuoka E, Makita M, Yamamura S (1989) Glassy state of pharmaceuticals. III: Thermal properties and stability of glassy pharmaceuticals and their binary glass systems. Chem Pharm Bull 37(4):1047–1050. doi:10.1248/cpb.37.1047

    Article  CAS  Google Scholar 

  • Garcia-Bennett AE, Che S, Miyasaka K, Sakamoto Y, Ohsuna T, Liu Z et al (2005) Studies of anionic surfactant templated mesoporous structures by electron microscopy. In: Abdelhamid S, Mietek J (eds) Studies in surface science and catalysis. Elsevier, Amsterdam, pp 11–18

    Google Scholar 

  • Gencoglu MF, Spurri A, Franko M, Chen J, Hensley DK, Heldt CL et al (2014) Biocompatibility of soft-templated mesoporous carbons. ACS Appl Mater Interfaces 6(17):15068–15077. doi:10.1021/am503076u

    Article  CAS  PubMed  Google Scholar 

  • Ghebremeskel A, Vemavarapu C, Lodaya M (2006) Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: stability testing of selected solid dispersions. Pharm Res 23(8):1928–1936. doi:10.1007/s11095-006-9034-1

    Article  CAS  PubMed  Google Scholar 

  • Gomes ME, Ribeiro AS, Malafaya PB, Reis RL, Cunha AM (2001) A new approach based on injection moulding to produce biodegradable starch-based polymeric scaffolds: morphology, mechanical and degradation behaviour. Biomaterials 22(9):883–889. doi:10.1016/S0142-9612(00)00211-8

    Article  CAS  PubMed  Google Scholar 

  • Gomes ME, Godinho JS, Tchalamov D, Cunha AM, Reis RL (2002) Alternative tissue engineering scaffolds based on starch: processing methodologies, morphology, degradation and mechanical properties. Mater Sci Eng C 20(1–2):19–26. doi:10.1016/S0928-4931(02)00008-5

    Article  Google Scholar 

  • Goyanes A, Buanz ABM, Hatton GB, Gaisford S, Basit AW (2015a) 3D printing of modified-release aminosalicylate (4-ASA and 5-ASA) tablets. Eur J Pharm Biopharm 89:157–162. doi:10.1016/j.ejpb.2014.12.003

    Article  CAS  PubMed  Google Scholar 

  • Goyanes A, Wang J, Buanz A, Martínez-Pacheco R, Telford R, Gaisford S et al (2015b) 3D printing of medicines: engineering novel oral devices with unique design and drug release characteristics. Mol Pharm 12(11):4077–4084. doi:10.1021/acs.molpharmaceut.5b00510

    Article  CAS  PubMed  Google Scholar 

  • Grohganz H, Löbmann K, Priemel P, Tarp Jensen K, Graeser K, Strachan C et al (2013) Amorphous drugs and dosage forms. J Drug Deliv Sci Technol 23(4):403–408. doi:10.1016/S1773-2247(13)50057-8

    Article  CAS  Google Scholar 

  • Gross BC, Erkal JL, Lockwood SY, Chen C, Spence DM (2014) Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences. Anal Chem 86(7):3240–3253. doi:10.1021/ac403397r

    Article  CAS  PubMed  Google Scholar 

  • Günther D, Heymel B, Franz Günther J, Ederer I (2014) Continuous 3D-printing for additive manufacturing. Rapid Prototyping J 20(4):320–327. doi:10.1108/RPJ-08-2012-0068

    Article  Google Scholar 

  • Gynther M, Laine K, Ropponen J, Leppänen J, Mannila A, Nevalainen T et al (2008) Large neutral amino acid transporter enables brain drug delivery via prodrugs. J Med Chem 51(4):932–936. doi:10.1021/jm701175d

    Article  CAS  PubMed  Google Scholar 

  • Hamid Q, Snyder J, Wang C, Timmer M, Hammer J, Guceri S et al (2011) Fabrication of three-dimensional scaffolds using precision extrusion deposition with an assisted cooling device. Biofabrication 3(3):034109

    Article  CAS  PubMed  Google Scholar 

  • Hancock BC (2002) Disordered drug delivery: destiny, dynamics and the Deborah number. J Pharm Pharmacol 54(6):737–746

    Article  CAS  PubMed  Google Scholar 

  • Hancock BC, Zografi G (1997) Characteristics and significance of the amorphous state in pharmaceutical systems. J Pharm Sci 86(1):1–12. doi:10.1021/js9601896

    Article  CAS  PubMed  Google Scholar 

  • Hancock BC, Shamblin SL, Zografi G (1995) Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures. Pharm Res 12(6):799–806

    Article  CAS  PubMed  Google Scholar 

  • Heikkilä T, Santos HA, Kumar N, Murzin DY, Salonen J, Laaksonen T et al (2010) Cytotoxicity study of ordered mesoporous silica MCM-41 and SBA-15 microparticles on Caco-2 cells. Eur J Pharm Biopharm 74(3):483–494. doi:10.1016/j.ejpb.2009.12.006

    Article  PubMed  CAS  Google Scholar 

  • Hirano A, Kameda T, Arakawa T, Shiraki K (2010) Arginine-assisted solubilization system for drug substances: solubility experiment and simulation. J Phys Chem B 114(42):13455–13462. doi:10.1021/jp101909a

    Article  CAS  PubMed  Google Scholar 

  • Hoque ME, Chuan YL, Pashby I (2012) Extrusion based rapid prototyping technique: an advanced platform for tissue engineering scaffold fabrication. Biopolymers 97(2):83–93. doi:10.1002/bip.21701

    Article  CAS  PubMed  Google Scholar 

  • Hu Y, Wang J, Zhi Z, Jiang T, Wang S (2011) Facile synthesis of 3D cubic mesoporous silica microspheres with a controllable pore size and their application for improved delivery of a water-insoluble drug. J Colloid Interface Sci 363(1):410–417. doi:10.1016/j.jcis.2011.07.022

    Article  CAS  PubMed  Google Scholar 

  • Hughey J, DiNunzio J, Bennett R, Brough C, Miller D, Ma H et al (2010) Dissolution enhancement of a drug exhibiting thermal and acidic decomposition characteristics by fusion processing: a comparative study of hot melt extrusion and KinetiSol® dispersing. AAPS PharmSciTech 11(2):760–774. doi:10.1208/s12249-010-9431-y

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hughey JR, Keen JM, Brough C, Saeger S, McGinity JW (2011) Thermal processing of a poorly water-soluble drug substance exhibiting a high melting point: the utility of KinetiSol® dispersing. Int J Pharm 419(1–2):222–230. doi:10.1016/j.ijpharm.2011.08.007

    Article  CAS  PubMed  Google Scholar 

  • Hughey JR, Keen JM, Miller DA, Brough C, McGinity JW (2012) Preparation and characterization of fusion processed solid dispersions containing a viscous thermally labile polymeric carrier. Int J Pharm 438(1–2):11–19. doi:10.1016/j.ijpharm.2012.08.032

    Article  CAS  PubMed  Google Scholar 

  • Hughey JR, Keen JM, Miller DA, Kolter K, Langley N, McGinity JW (2013) The use of inorganic salts to improve the dissolution characteristics of tablets containing Soluplus®-based solid dispersions. Eur J Pharm Sci 48(4–5):758–766. doi:10.1016/j.ejps.2013.01.004

    Article  CAS  PubMed  Google Scholar 

  • Hughey JR, Keen JM, Bennett RC, Obara S, McGinity JW (2014) The incorporation of low-substituted hydroxypropyl cellulose into solid dispersion systems. Drug Dev Ind Pharm 41:1294–1301

    Article  PubMed  CAS  Google Scholar 

  • Igantious F, Sun L, Inventors (2004) Electrospun amorphous pharmaceutical compositions patent WO2004014304

    Google Scholar 

  • Ignatious F, Sun L, Lee C-P, Baldoni J (2010) Electrospun nanofibers in oral drug delivery. Pharm Res 27(4):576–588

    Article  CAS  PubMed  Google Scholar 

  • Inagaki S, Fukushima Y, Kuroda K (1993) Synthesis of highly ordered mesoporous materials from a layered polysilicate. J Chem Soc Chem Commun 8:680–682. doi:10.1039/C39930000680

    Article  Google Scholar 

  • Iulia D, Ursan BLC, Andrea Pierce BS (2003) Three-dimensional drug printing: a structured review. J Am Pharm Assoc 53:136–144. doi:10.1331/JAPhA.2013.12217

    Google Scholar 

  • Janssens S, Van den Mooter G (2009) Review: physical chemistry of solid dispersions. J Pharm Pharmacol 61(12):1571–1586. doi:10.1211/jpp.61.12.0001

    Article  CAS  PubMed  Google Scholar 

  • Jensen KT, Blaabjerg LI, Lenz E, Bohr A, Grohganz H, Kleinebudde P et al (2015a) Preparation and characterization of spray-dried co-amorphous drug–amino acid salts. J Pharm Pharmacol 68(5):615–624. doi:10.1111/jphp.12458

    Article  PubMed  CAS  Google Scholar 

  • Jensen KT, Larsen FH, Cornett C, Löbmann K, Grohganz H, Rades T (2015b) Formation mechanism of coamorphous drug–amino acid mixtures. Mol Pharm 12(7):2484–2492. doi:10.1021/acs.molpharmaceut.5b00295

    Article  CAS  PubMed  Google Scholar 

  • Jiang H, Wang T, Wang L, Sun C, Jiang T, Cheng G et al (2012) Development of an amorphous mesoporous TiO2 nanosphere as a novel carrier for poorly water-soluble drugs: effect of different crystal forms of TiO2 carriers on drug loading and release behaviors. Micropor Mesopor Mater 153:124–130. doi:10.1016/j.micromeso.2011.12.013

    Article  CAS  Google Scholar 

  • Keen JM, Hughey JR, Bennett RC, Jannin V, Rosiaux Y, Marchaud D et al (2015) Effect of tablet structure on controlled release from supersaturating solid dispersions containing glyceryl behenate. Mol Pharm 12(1):120–126. doi:10.1021/mp500480y

    Article  CAS  PubMed  Google Scholar 

  • Kenawy E-R, Bowlin GL, Mansfield K, Layman J, Simpson DG, Sanders EH et al (2002) Release of tetracycline hydrochloride from electrospun poly (ethylene-co-vinylacetate), poly (lactic acid), and a blend. J Control Release 81(1):57–64

    Article  CAS  Google Scholar 

  • Kim M-S (2013) Soluplus-coated colloidal silica nanomatrix system for enhanced supersaturation and oral absorption of poorly water-soluble drugs. Artif Cells Nanomed Biotechnol 41(6):363–367

    Article  CAS  PubMed  Google Scholar 

  • Kim T-W, Chung P-W, Slowing II, Tsunoda M, Yeung ES, Lin VSY (2008) Structurally ordered mesoporous carbon nanoparticles as transmembrane delivery vehicle in human cancer cells. Nano Lett 8(11):3724–3727. doi:10.1021/nl801976m

    Article  CAS  PubMed  Google Scholar 

  • Kinnari P, Mäkilä E, Heikkilä T, Salonen J, Hirvonen J, Santos HA (2011) Comparison of mesoporous silicon and non-ordered mesoporous silica materials as drug carriers for itraconazole. Int J Pharm 414(1–2):148–156. doi:10.1016/j.ijpharm.2011.05.021

    Article  CAS  PubMed  Google Scholar 

  • Knapik J, Wojnarowska Z, Grzybowska K, Jurkiewicz K, Tajber L, Paluch M (2015) Molecular dynamics and physical stability of coamorphous ezetimib and indapamide mixtures. Mol Pharm 12(10):3610–3619. doi:10.1021/acs.molpharmaceut.5b00334

    Article  CAS  PubMed  Google Scholar 

  • Kresge C, Leonowicz M, Roth W, Vartuli J, Beck J (1992) Ordered mesoporous molecular sieves synthesized by a liquid-crystal template mechanism. Nature 359(6397):710–712

    Article  CAS  Google Scholar 

  • Kruk M, Jaroniec M, Ko CH, Ryoo R (2000) Characterization of the porous structure of SBA-15. Chem Mater 12(7):1961–1968

    Article  CAS  Google Scholar 

  • Kulig K, David B-O, Cantrill SV, Rosen P, Rumack BH (1985) Management of acutely poisoned patients without gastric emptying. Ann Emerg Med 14(6):562–567. doi:10.1016/S0196-0644(85)80780-0

    Article  CAS  PubMed  Google Scholar 

  • Kumar A, Ganjyal GM, Jones DD, Hanna MA (2008) Modeling residence time distribution in a twin-screw extruder as a series of ideal steady-state flow reactors. J Food Eng 84(3):441–448

    Article  Google Scholar 

  • LaFountaine J, Prasad L, Brough C, Miller D, McGinity J, Williams R III (2015a) Thermal processing of PVP- and HPMC-based amorphous solid dispersions. AAPS PharmSciTech 17(1):120–132. doi:10.1208/s12249-015-0417-7

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • LaFountaine JS, McGinity JW, Williams RO III (2015b) Challenges and strategies in thermal processing of amorphous solid dispersions: a review. AAPS PharmSciTech 17(1):43–55

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Laitinen R, Löbmann K, Strachan CJ, Grohganz H, Rades T (2013) Emerging trends in the stabilization of amorphous drugs. Int J Pharm 453(1):65–79. doi:10.1016/j.ijpharm.2012.04.066

    Article  CAS  PubMed  Google Scholar 

  • Laitinen R, Löbmann K, Grohganz H, Strachan C, Rades T (2014) Amino acids as co-amorphous excipients for simvastatin and glibenclamide: physical properties and stability. Mol Pharm 11(7):2381–2389. doi:10.1021/mp500107s

    Article  CAS  PubMed  Google Scholar 

  • Lakshman JP, Cao Y, Kowalski J, Serajuddin ATM (2008) Application of melt extrusion in the development of a physically and chemically stable high-energy amorphous solid dispersion of a poorly water-soluble drug. Mol Pharm 5(6):994–1002. doi:10.1021/mp8001073

    Article  CAS  PubMed  Google Scholar 

  • Lenz E, Jensen KT, Blaabjerg LI, Knop K, Grohganz H, Löbmann K et al (2015) Solid-state properties and dissolution behaviour of tablets containing co-amorphous indomethacin–arginine. Eur J Pharm Biopharm 96:44–52. doi:10.1016/j.ejpb.2015.07.011

    Article  CAS  PubMed  Google Scholar 

  • Leuner C, Dressman J (2000) Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm 50(1):47–60. doi:10.1016/S0939-6411(00)00076-X

    Article  CAS  PubMed  Google Scholar 

  • Liang C, Li Z, Dai S (2008) Mesoporous carbon materials: synthesis and modification. Angew Chem Int Ed 47(20):3696–3717. doi:10.1002/anie.200702046

    Article  CAS  Google Scholar 

  • Lipinski CA (2004) Lead-and drug-like compounds: the rule-of-five revolution. Drug Discov Today Technol 1(4):337–341

    Article  CAS  PubMed  Google Scholar 

  • Lipinski CA, Lombardo F, Dominy BW, Feeney PJ (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46(1–3):3–26. doi:10.1016/S0169-409X(00)00129-0

    Article  CAS  PubMed  Google Scholar 

  • Liu K-S, Liu H, Qi J-H, Liu Q-Y, Liu Z, Xia M et al (2012) SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells. Cancer Lett 318(2):180–188

    Article  CAS  PubMed  Google Scholar 

  • Löbmann K, Laitinen R, Grohganz H, Gordon KC, Strachan C, Rades T (2011) Coamorphous drug systems: enhanced physical stability and dissolution rate of indomethacin and naproxen. Mol Pharm 8(5):1919–1928. doi:10.1021/mp2002973

    Article  PubMed  CAS  Google Scholar 

  • Löbmann K, Strachan C, Grohganz H, Rades T, Korhonen O, Laitinen R (2012) Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions. Eur J Pharm Biopharm 81(1):159–169. doi:10.1016/j.ejpb.2012.02.004

    Article  PubMed  CAS  Google Scholar 

  • Löbmann K, Grohganz H, Laitinen R, Strachan C, Rades T (2013a) Amino acids as co-amorphous stabilizers for poorly water soluble drugs—part 1: preparation, stability and dissolution enhancement. Eur J Pharm Biopharm 85(3, Part B):873–881. doi:10.1016/j.ejpb.2013.03.014

    Article  PubMed  CAS  Google Scholar 

  • Löbmann K, Laitinen R, Grohganz H, Strachan C, Rades T, Gordon KC (2013b) A theoretical and spectroscopic study of co-amorphous naproxen and indomethacin. Int J Pharm 453(1):80–87. doi:10.1016/j.ijpharm.2012.05.016

    Article  PubMed  CAS  Google Scholar 

  • Löbmann K, Laitinen R, Strachan C, Rades T, Grohganz H (2013c) Amino acids as co-amorphous stabilizers for poorly water-soluble drugs—part 2: molecular interactions. Eur J Pharm Biopharm 85(3):882–888. doi:10.1016/j.ejpb.2013.03.026

    Article  PubMed  CAS  Google Scholar 

  • Löbmann K, Jensen KT, Laitinen R, Rades T, Strachan CJ, Grohganz H (2014) Stabilized amorphous solid dispersions with small molecule excipients. In: Shah N, Sandhu H, Choi DS, Chokshi H, Malick AW (eds) Amorphous solid dispersions. Advances in delivery science and technology. Springer, New York, pp 613–636

    Google Scholar 

  • Lu Q, Zografi G (1998) Phase behavior of binary and ternary amorphous mixtures containing indomethacin, citric acid, and PVP. Pharm Res 15(8):1202–1206. doi:10.1023/A:1011983606606

    Article  CAS  PubMed  Google Scholar 

  • Lu J, Liong M, Sherman S, Xia T, Kovochich M, Nel A et al (2007) Mesoporous silica nanoparticles for cancer therapy: energy-dependent cellular uptake and delivery of paclitaxel to cancer cells. Nanobiotechnol 3(2):89–95. doi:10.1007/s12030-008-9003-3

    Article  CAS  Google Scholar 

  • Ma T-Y, Liu L, Yuan Z-Y (2013) Direct synthesis of ordered mesoporous carbons. Chem Soc Rev 42(9):3977–4003. doi:10.1039/C2CS35301F

    Article  CAS  PubMed  Google Scholar 

  • Maeng H-J, Kim E-S, Chough C, Joung M, Lim JW, Shim C-K et al (2014) Addition of amino acid moieties to lapatinib increases the anti-cancer effect via amino acid transporters. Biopharm Drug Dispos 35(1):60–69. doi:10.1002/bdd.1872

    Article  CAS  PubMed  Google Scholar 

  • Malone E, Lipson H (2007) Fab@ Home: the personal desktop fabricator kit. Rapid Prototyping J 13(4):245–255

    Article  Google Scholar 

  • Mamaeva V, Sahlgren C, Lindén M (2013) Mesoporous silica nanoparticles in medicine—recent advances. Adv Drug Deliv Rev 65(5):689–702

    Article  CAS  PubMed  Google Scholar 

  • Masuda T, Yoshihashi Y, Yonemochi E, Fujii K, Uekusa H, Terada K (2012) Cocrystallization and amorphization induced by drug–excipient interaction improves the physical properties of acyclovir. Int J Pharm 422(1):160–169

    Article  CAS  PubMed  Google Scholar 

  • Mekaru H, Lu J, Tamanoi F (2015) Development of mesoporous silica-based nanoparticles with controlled release capability for cancer therapy. Adv Drug Deliv Rev 95:40–49. doi:10.1016/j.addr.2015.09.009

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mellaerts R, Jammaer JAG, Van Speybroeck M, Chen H, Humbeeck JV, Augustijns P et al (2008a) Physical state of poorly water soluble therapeutic molecules loaded into SBA-15 ordered mesoporous silica carriers: a case study with itraconazole and ibuprofen. Langmuir 24(16):8651–8659. doi:10.1021/la801161g

    Article  CAS  PubMed  Google Scholar 

  • Mellaerts R, Mols R, Jammaer JAG, Aerts CA, Annaert P, Van Humbeeck J et al (2008b) Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica. Eur J Pharm Biopharm 69(1):223–230. doi:10.1016/j.ejpb.2007.11.006

    Article  CAS  PubMed  Google Scholar 

  • Mellaerts R, Houthoofd K, Elen K, Chen H, Van Speybroeck M, Van Humbeeck J et al (2010) Aging behavior of pharmaceutical formulations of itraconazole on SBA-15 ordered mesoporous silica carrier material. Micropor Mesopor Mater 130(1–3):154–161. doi:10.1016/j.micromeso.2009.10.026

    Article  CAS  Google Scholar 

  • Meng H, Liong M, Xia T, Li Z, Ji Z, Zink JI et al (2010) Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line. ACS Nano 4(8):4539–4550. doi:10.1021/nn100690m

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Miller DA (2007) Improved oral absorption of poorly water-soluble drugs by advanced solid dispersion systems. PhD dissertation. The University of Texas at Austin, Austin, TX

    Google Scholar 

  • Mizushima Y, Ikoma T, Tanaka J, Hoshi K, Ishihara T, Ogawa Y et al (2006) Injectable porous hydroxyapatite microparticles as a new carrier for protein and lipophilic drugs. J Control Release 110(2):260–265. doi:10.1016/j.jconrel.2005.09.051

    Article  CAS  PubMed  Google Scholar 

  • Muñoz B, Rámila A, Pérez-Pariente J, Díaz I, Vallet-Regí M (2003) MCM-41 organic modification as drug delivery rate regulator. Chem Mater 15(2):500–503. doi:10.1021/cm021217q

    Article  CAS  Google Scholar 

  • Mura P, Maestrelli F, Cirri M (2003) Ternary systems of naproxen with hydroxypropyl-β-cyclodextrin and aminoacids. Int J Pharm 260(2):293–302. doi:10.1016/S0378-5173(03)00265-5

    Article  CAS  PubMed  Google Scholar 

  • Mura P, Bettinetti GP, Cirri M, Maestrelli F, Sorrenti M, Catenacci L (2005) Solid-state characterization and dissolution properties of Naproxen–Arginine–Hydroxypropyl-β-cyclodextrin ternary system. Eur J Pharm Biopharm 59(1):99–106. doi:10.1016/j.ejpb.2004.05.005

    Article  CAS  PubMed  Google Scholar 

  • Murphy DK, Rabel S (2008) Thermal analysis and calorimetric methods for the characterization of new crystal forms. Drugs Pharm Sci 178:279

    CAS  Google Scholar 

  • Nagy ZK, Balogh A, Vajna B, Farkas A, Patyi G, Kramarics Á et al (2012) Comparison of electrospun and extruded soluplus®-based solid dosage forms of improved dissolution. J Pharm Sci 101(1):322–332. doi:10.1002/jps.22731

    Article  CAS  PubMed  Google Scholar 

  • Nagy ZK, Balogh A, Drávavölgyi G, Ferguson J, Pataki H, Vajna B et al (2013) Solvent-free melt electrospinning for preparation of fast dissolving drug delivery system and comparison with solvent-based electrospun and melt extruded systems. J Pharm Sci 102(2):508–517. doi:10.1002/jps.23374

    Article  CAS  PubMed  Google Scholar 

  • Nakamatsu J, Torres FG, Troncoso OP, Min-Lin Y, Boccaccini AR (2006) Processing and characterization of porous structures from chitosan and starch for tissue engineering scaffolds. Biomacromolecules 7(12):3345–3355. doi:10.1021/bm0605311

    Article  CAS  PubMed  Google Scholar 

  • Neuvonen P, Olkkola K (1988) Oral activated charcoal in the treatment of intoxications. Med Toxicol Adverse Drug Exp 3(1):33–58. doi:10.1007/BF03259930

    CAS  PubMed  Google Scholar 

  • Oh WK, Yoon H, Jang J (2010) Size control of magnetic carbon nanoparticles for drug delivery. Biomaterials 31(6):1342–1348. doi:10.1016/j.biomaterials.2009.10.018

    Article  CAS  PubMed  Google Scholar 

  • Peng H, Dong R, Wang S, Zhang Z, Luo M, Bai C et al (2013) A pH-responsive nano-carrier with mesoporous silica nanoparticles cores and poly(acrylic acid) shell-layers: fabrication, characterization and properties for controlled release of salidroside. Int J Pharm 446(1–2):153–159. doi:10.1016/j.ijpharm.2013.01.071

    Article  CAS  PubMed  Google Scholar 

  • Qu F, Zhu G, Huang S, Li S, Qiu S (2006) Effective controlled release of captopril by silylation of mesoporous MCM-41. ChemPhysChem 7(2):400–406

    Article  CAS  PubMed  Google Scholar 

  • Reneker DH, Chun I (1996) Nanometre diameter fibres of polymer, produced by electrospinning. Nanotechnology 7(3):216

    Article  CAS  Google Scholar 

  • Repka MA, Gerding TG, Repka SL, McGinity JW (1999) Influence of plasticizers and drugs on the physical-mechanical properties of hydroxypropylcellulose films prepared by hot melt extrusion. Drug Dev Ind Pharm 25(5):625–633

    Article  CAS  PubMed  Google Scholar 

  • Repka MA, Prodduturi S, Stodghill SP (2003) Production and characterization of hot-melt extruded films containing clotrimazole. Drug Dev Ind Pharm 29(7):757–765

    Article  CAS  PubMed  Google Scholar 

  • Roberts AD, Zhang H (2013) Poorly water-soluble drug nanoparticles via solvent evaporation in water-soluble porous polymers. Int J Pharm 447(1–2):241–250. doi:10.1016/j.ijpharm.2013.03.001

    Article  CAS  PubMed  Google Scholar 

  • Rosenholm JM, Sahlgren C, Linden M (2010) Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles—opportunities & challenges. Nanoscale 2(10):1870–1883. doi:10.1039/C0NR00156B

    Article  CAS  PubMed  Google Scholar 

  • Rowe CW, Katstra WE, Palazzolo RD, Giritlioglu B, Teung P, Cima MJ (2000) Multimechanism oral dosage forms fabricated by three dimensional printing™. J Control Release 66(1):11–17. doi:10.1016/S0168-3659(99)00224-2

    Article  CAS  PubMed  Google Scholar 

  • Rowe RC, Sheskey PJ, Cook WG, Fenton ME, American Pharmacists A (2012) Handbook of pharmaceutical excipients. Pharmaceutical Press, London

    Google Scholar 

  • Saha D, Warren KE, Naskar AK (2014a) Controlled release of antipyrine from mesoporous carbons. Micropor Mesopor Mater 196:327–334. doi:10.1016/j.micromeso.2014.05.024

    Article  CAS  Google Scholar 

  • Saha D, Warren KE, Naskar AK (2014b) Soft-templated mesoporous carbons as potential materials for oral drug delivery. Carbon 71:47–57. doi:10.1016/j.carbon.2014.01.005

    Article  CAS  Google Scholar 

  • Saha D, Moken T, Chen J, Hensley DK, Delaney K, Hunt MA et al (2015) Micro-/mesoporous carbons for controlled release of antipyrine and indomethacin. RSC Adv 5(30):23699–23707. doi:10.1039/C5RA00251F

    Article  CAS  Google Scholar 

  • Sandler N, Salmela I, Fallarero A, Rosling A, Khajeheian M, Kolakovic R et al (2014) Towards fabrication of 3D printed medical devices to prevent biofilm formation. Int J Pharm 459(1–2):62–64. doi:10.1016/j.ijpharm.2013.11.001

    Article  CAS  PubMed  Google Scholar 

  • Sekiguchi K, Obi N (1961) Studies on absorption of eutectic mixture. I. A comparison of the behavior of eutectic mixture of sulfathiazole and that of ordinary sulfathiazole in man. Chem Pharm Bull 9(11):866–872

    Article  CAS  Google Scholar 

  • Serajuddin A (1999) Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs. J Pharm Sci 88(10):1058–1066

    Article  CAS  PubMed  Google Scholar 

  • Shen SC, Ng WK, Chia L, Dong YC, Tan RB (2010) Stabilized amorphous state of ibuprofen by co-spray drying with mesoporous SBA-15 to enhance dissolution properties. J Pharm Sci 99(4):1997–2007

    Article  CAS  PubMed  Google Scholar 

  • Skowyra J, Pietrzak K, Alhnan MA (2015) Fabrication of extended-release patient-tailored prednisolone tablets via fused deposition modelling (FDM) 3D printing. Eur J Pharm Sci 68:11–17. doi:10.1016/j.ejps.2014.11.009

    Article  CAS  PubMed  Google Scholar 

  • Slowing I, Trewyn BG, Lin VSY (2006) Effect of surface functionalization of MCM-41-type mesoporous silica nanoparticles on the endocytosis by human cancer cells. J Am Chem Soc 128(46):14792–14793. doi:10.1021/ja0645943

    Article  CAS  PubMed  Google Scholar 

  • Song S-W, Hidajat K, Kawi S (2005) Functionalized SBA-15 materials as carriers for controlled drug delivery: influence of surface properties on matrix-drug interactions. Langmuir 21(21):9568–9575

    Article  CAS  PubMed  Google Scholar 

  • Tang Q, Xu Y, Wu D, Sun Y (2006) A study of carboxylic-modified mesoporous silica in controlled delivery for drug famotidine. J Solid State Chem 179(5):1513–1520

    Article  CAS  Google Scholar 

  • Tang Q, Chen Y, Chen J, Li J, Xu Y, Wu D et al (2010) Drug delivery from hydrophobic-modified mesoporous silicas: control via modification level and site-selective modification. J Solid State Chem 183(1):76–83

    Article  CAS  Google Scholar 

  • Teja A, Musmade PB, Khade AB, Dengale SJ (2015) Simultaneous improvement of solubility and permeability by fabricating binary glassy materials of Talinolol with Naringin: solid state characterization, in-vivo in-situ evaluation. Eur J Pharm Sci 78:234–244. doi:10.1016/j.ejps.2015.08.002

    Article  CAS  PubMed  Google Scholar 

  • Thomas MJK, Slipper I, Walunj A, Jain A, Favretto ME, Kallinteri P et al (2010) Inclusion of poorly soluble drugs in highly ordered mesoporous silica nanoparticles. Int J Pharm 387(1–2):272–277. doi:10.1016/j.ijpharm.2009.12.023

    Article  CAS  PubMed  Google Scholar 

  • Trasi NS, Taylor LS (2015) Dissolution performance of binary amorphous drug combinations—impact of a second drug on the maximum achievable supersaturation. Int J Pharm 496(2):282–290. doi:10.1016/j.ijpharm.2015.10.026

    Article  CAS  PubMed  Google Scholar 

  • Tsume Y, Hilfinger J, Amidon G (2011) Potential of amino acid/dipeptide monoester prodrugs of floxuridine in facilitating enhanced delivery of active drug to interior sites of tumors: a two-tier monolayer in vitro study. Pharm Res 28(10):2575–2588. doi:10.1007/s11095-011-0485-7

    Article  CAS  PubMed  Google Scholar 

  • Ukmar T, Planinšek O (2010) Ordered mesoporous silicates as matrices for controlled release of drugs. Acta Pharm 60(4):373–385

    Article  CAS  PubMed  Google Scholar 

  • Vallet-Regi M, Rámila A, del Real RP, Pérez-Pariente J (2001) A new property of MCM-41: drug delivery system. Chem Mater 13(2):308–311. doi:10.1021/cm0011559

    Article  CAS  Google Scholar 

  • Van Speybroeck M, Mols R, Mellaerts R, Thi TD, Martens JA, Humbeeck JV et al (2010) Combined use of ordered mesoporous silica and precipitation inhibitors for improved oral absorption of the poorly soluble weak base itraconazole. Eur J Pharm Biopharm 75(3):354–365. doi:10.1016/j.ejpb.2010.04.009

    Article  PubMed  CAS  Google Scholar 

  • Verreck G (2012) The influence of plasticizers in hot-melt extrusion. Hot-Melt Extrusion: Pharmaceutical Applications:93–112

    Google Scholar 

  • Verreck G, Chun I, Peeters J, Rosenblatt J, Brewster ME (2003a) Preparation and characterization of nanofibers containing amorphous drug dispersions generated by electrostatic spinning. Pharm Res 20(5):810–817

    Article  CAS  PubMed  Google Scholar 

  • Verreck G, Chun I, Rosenblatt J, Peeters J, Van Dijck A, Mensch J et al (2003b) Incorporation of drugs in an amorphous state into electrospun nanofibers composed of a water-insoluble, nonbiodegradable polymer. J Control Release 92(3):349–360

    Article  CAS  PubMed  Google Scholar 

  • Verreck G, Decorte A, Heymans K, Adriaensen J, Liu D, Tomasko D et al (2006) Hot stage extrusion of p-amino salicylic acid with EC using CO 2 as a temporary plasticizer. Int J Pharm 327(1):45–50

    Article  CAS  PubMed  Google Scholar 

  • Vialpando M, Aerts A, Persoons J, Martens J, Van Den Mooter G (2011) Evaluation of ordered mesoporous silica as a carrier for poorly soluble drugs: influence of pressure on the structure and drug release. J Pharm Sci 100(8):3411–3420. doi:10.1002/jps.22535

    Article  CAS  PubMed  Google Scholar 

  • Vialpando M, Backhuijs F, Martens JA, Van den Mooter G (2012) Risk assessment of premature drug release during wet granulation of ordered mesoporous silica loaded with poorly soluble compounds itraconazole, fenofibrate, naproxen, and ibuprofen. Eur J Pharm Biopharm 81(1):190–198. doi:10.1016/j.ejpb.2012.01.012

    Article  CAS  PubMed  Google Scholar 

  • Wang F, Shor L, Darling A, Khalil S, Sun W, Güçeri S et al (2004) Precision extruding deposition and characterization of cellular poly-ε-caprolactone tissue scaffolds. Rapid Prototyping J 10(1):42–49. doi:10.1108/13552540410512525

    Article  Google Scholar 

  • Wang G, Otuonye AN, Blair EA, Denton K, Tao Z, Asefa T (2009) Functionalized mesoporous materials for adsorption and release of different drug molecules: a comparative study. J Solid State Chem 182(7):1649–1660

    Article  CAS  Google Scholar 

  • Wang F, Hui H, Barnes TJ, Barnett C, Prestidge CA (2010) Oxidized mesoporous silicon microparticles for improved oral delivery of poorly soluble drugs. Mol Pharm 7(1):227–236. doi:10.1021/mp900221e

    Article  CAS  PubMed  Google Scholar 

  • Wang X, Liu P, Tian Y (2011a) Ordered mesoporous carbons for ibuprofen drug loading and release behavior. Micropor Mesopor Mater 142(1):334–340. doi:10.1016/j.micromeso.2010.12.018

    Article  CAS  Google Scholar 

  • Wang X, Liu P, Tian Y, Zang L (2011b) Novel synthesis of Fe-containing mesoporous carbons and their release of ibuprofen. Micropor Mesopor Mater 145(1–3):98–103. doi:10.1016/j.micromeso.2011.04.033

    Article  CAS  Google Scholar 

  • Wang Y, Zhao Q, Hu Y, Sun L, Bai L, Jiang T et al (2013) Ordered nanoporous silica as carriers for improved delivery of water insoluble drugs: a comparative study between three dimensional and two dimensional macroporous silica. Int J Nanomedicine 8:4015–4031. doi:10.2147/IJN.S52605

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wang T, Zhao P, Zhao Q, Wang B, Wang S (2014) The mechanism for increasing the oral bioavailability of poorly water-soluble drugs using uniform mesoporous carbon spheres as a carrier. Drug Deliv 23:420–428

    Article  CAS  Google Scholar 

  • Wang Y, Zhao Q, Han N, Bai L, Li J, Liu J et al (2015) Mesoporous silica nanoparticles in drug delivery and biomedical applications. Nanomed Nanotechnol Biol Med 11(2):313–327. doi:10.1016/j.nano.2014.09.014

    Article  CAS  Google Scholar 

  • Wu C, Wang Z, Zhi Z, Jiang T, Zhang J, Wang S (2011) Development of biodegradable porous starch foam for improving oral delivery of poorly water soluble drugs. Int J Pharm 403(1–2):162–169. doi:10.1016/j.ijpharm.2010.09.040

    Article  CAS  PubMed  Google Scholar 

  • Xu W, Gao Q, Xu Y, Wu D, Sun Y, Shen W et al (2008) Controlled drug release from bifunctionalized mesoporous silica. J Solid State Chem 181(10):2837–2844

    Article  CAS  Google Scholar 

  • Xu W, Riikonen J, Lehto V-P (2013) Mesoporous systems for poorly soluble drugs. Int J Pharm 453(1):181–197. doi:10.1016/j.ijpharm.2012.09.008

    Article  CAS  PubMed  Google Scholar 

  • Yachamaneni S, Yushin G, Yeon S-H, Gogotsi Y, Howell C, Sandeman S et al (2010) Mesoporous carbide-derived carbon for cytokine removal from blood plasma. Biomaterials 31(18):4789–4794

    Article  CAS  PubMed  Google Scholar 

  • Yamamura S, Momose Y, Takahashi K, Nagatani S (1996) Solid-state interaction between cimetidine and naproxen. Drug Stability 1:173–178

    CAS  Google Scholar 

  • Yamamura S, Gotoh H, Sakamoto Y, Momose Y (2000) Physicochemical properties of amorphous precipitates of cimetidine–indomethacin binary system. Eur J Pharm Biopharm 49(3):259–265. doi:10.1016/S0939-6411(00)00060-6

    Article  CAS  PubMed  Google Scholar 

  • Yamamura S, Gotoh H, Sakamoto Y, Momose Y (2002) Physicochemical properties of amorphous salt of cimetidine and diflunisal system. Int J Pharm 241(2):213–221. doi:10.1016/S0378-5173(02)00195-3

    Article  CAS  PubMed  Google Scholar 

  • Yang Q, Wang S, Fan P, Wang L, Di Y, Lin K et al (2005) pH-responsive carrier system based on carboxylic acid modified mesoporous silica and polyelectrolyte for drug delivery. Chem Mater 17(24):5999–6003

    Article  CAS  Google Scholar 

  • Yang P, Gai S, Lin J (2012) Functionalized mesoporous silica materials for controlled drug delivery. Chem Soc Rev 41(9):3679–3698. doi:10.1039/C2CS15308D

    Article  CAS  PubMed  Google Scholar 

  • Ye F, Guo H, Zhang H, He X (2010) Polymeric micelle-templated synthesis of hydroxyapatite hollow nanoparticles for a drug delivery system. Acta Biomater 6(6):2212–2218

    Article  CAS  PubMed  Google Scholar 

  • Yu D-G, Zhu L-M, Branford-White CJ, Yang J-H, Wang X, Li Y et al (2011) Solid dispersions in the form of electrospun core-sheath nanofibers. Int J Nanomedicine 6:3271–3280. doi:10.2147/IJN.S27468

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang C, Li C, Huang S, Hou Z, Cheng Z, Yang P et al (2010a) Self-activated luminescent and mesoporous strontium hydroxyapatite nanorods for drug delivery. Biomaterials 31(12):3374–3383

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Zhi Z, Jiang T, Zhang J, Wang Z, Wang S (2010b) Spherical mesoporous silica nanoparticles for loading and release of the poorly water-soluble drug telmisartan. J Control Release 145(3):257–263. doi:10.1016/j.jconrel.2010.04.029

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Zhang J, Jiang T, Wang S (2011) Inclusion of the poorly water-soluble drug simvastatin in mesocellular foam nanoparticles: drug loading and release properties. Int J Pharm 410(1–2):118–124. doi:10.1016/j.ijpharm.2010.07.040

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Wang J, Bai X, Jiang T, Zhang Q, Wang S (2012) Mesoporous Silica Nanoparticles for Increasing the Oral Bioavailability and Permeation of Poorly Water Soluble Drugs. Mol Pharm 9(3):505–513. doi:10.1021/mp200287c

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Zhi Z, Li X, Gao J, Song Y (2013) Carboxylated mesoporous carbon microparticles as new approach to improve the oral bioavailability of poorly water-soluble carvedilol. Int J Pharm 454(1):403–411. doi:10.1016/j.ijpharm.2013.07.009

    Article  CAS  PubMed  Google Scholar 

  • Zhang L, Li Y, Jin Z, Chan KM, Yu JC (2015a) Mesoporous carbon/CuS nanocomposites for pH-dependent drug delivery and near-infrared chemo-photothermal therapy. RSC Adv 5(113):93226–93233. doi:10.1039/C5RA19458J

    Article  CAS  Google Scholar 

  • Zhang X, Zhang T, Ye Y, Chen H, Sun H, Zhou X et al (2015b) Phospholipid-stabilized mesoporous carbon nanospheres as versatile carriers for systemic delivery of amphiphobic SNX-2112 (a Hsp90 inhibitor) with enhanced antitumor effect. Eur J Pharm Biopharm 94:30–41. doi:10.1016/j.ejpb.2015.04.023

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y, Zhao Q, Zhu W, Zhang L, Han J, Lin Q et al (2015c) Synthesis and evaluation of mesoporous carbon/lipid bilayer nanocomposites for improved oral delivery of the poorly water-soluble drug, nimodipine. Pharm Res 32(7):2372–2383. doi:10.1007/s11095-015-1630-5

    Article  CAS  PubMed  Google Scholar 

  • Zhao D, Feng J, Huo Q, Melosh N, Fredrickson GH, Chmelka BF et al (1998) Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores. Science 279(5350):548–552

    Article  CAS  PubMed  Google Scholar 

  • Zhao P, Jiang H, Jiang T, Zhi Z, Wu C, Sun C et al (2012a) Inclusion of celecoxib into fibrous ordered mesoporous carbon for enhanced oral bioavailability and reduced gastric irritancy. Eur J Pharm Sci 45(5):639–647. doi:10.1016/j.ejps.2012.01.003

    Article  CAS  PubMed  Google Scholar 

  • Zhao P, Wang L, Sun C, Jiang T, Zhang J, Zhang Q et al (2012b) Uniform mesoporous carbon as a carrier for poorly water soluble drug and its cytotoxicity study. Eur J Pharm Biopharm 80(3):535–543. doi:10.1016/j.ejpb.2011.12.002

    Article  CAS  PubMed  Google Scholar 

  • Zhao Q, Wang T, Wang J, Zheng L, Jiang T, Cheng G et al (2012c) Fabrication of mesoporous hydroxycarbonate apatite for oral delivery of poorly water-soluble drug carvedilol. J Non-Crystal Solids 358(2):229–235. doi:10.1016/j.jnoncrysol.2011.09.020

    Article  CAS  Google Scholar 

  • Zhu Y, Shah NH, Malick AW, Infeld MH, McGinity JW (2002) Solid-state plasticization of an acrylic polymer with chlorpheniramine maleate and triethyl citrate. Int J Pharm 241(2):301–310

    Article  CAS  PubMed  Google Scholar 

  • Zhu Y, Mehta KA, McGinity JW (2006) Influence of plasticizer level on the drug release from sustained release film coated and hot-melt extruded dosage forms. Pharm Dev Technol 11(3):285–294

    Article  CAS  PubMed  Google Scholar 

  • Zhu S, Chen C, Chen Z, Liu X, Li Y, Shi Y et al (2011) Thermo-responsive polymer-functionalized mesoporous carbon for controlled drug release. Mater Chem Phys 126(1–2):357–363. doi:10.1016/j.matchemphys.2010.11.013

    Article  CAS  Google Scholar 

  • Zhu J, Liao L, Bian X, Kong J, Yang P, Liu B (2012) pH-controlled delivery of doxorubicin to cancer cells, based on small mesoporous carbon nanospheres. Small 8(17):2715–2720

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, 2409 University Station, A1920, Austin, TX, 78712, USA

    Leena Kumari Prasad, James W. McGinity & Robert O. Williams III

  2. Banner Life Sciences, 4215 Premier Drive, High Point, NC, 27265, USA

    Justin R. Hughey

  3. DisperSol Technologies, LLC, 111 W Cooperative Way, Georgetown, TX, 78626, USA

    Dave A. Miller

Authors
  1. Leena Kumari Prasad
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Justin R. Hughey
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. James W. McGinity
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dave A. Miller
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Robert O. Williams III
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Leena Kumari Prasad .

Editor information

Editors and Affiliations

  1. Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA

    Robert O. Williams III

  2. Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, Texas, USA

    Alan B. Watts

  3. DisperSol Technologies, LLC, Georgetown, Texas, USA

    Dave A. Miller

Rights and permissions

Reprints and permissions

Copyright information

© 2016 American Association of Pharmaceutical Scientists

About this chapter

Cite this chapter

Prasad, L.K., Hughey, J.R., McGinity, J.W., Miller, D.A., Williams, R.O. (2016). Emerging Technologies to Increase the Bioavailability of Poorly Water-Soluble Drugs. In: Williams III, R., Watts, A., Miller, D. (eds) Formulating Poorly Water Soluble Drugs. AAPS Advances in the Pharmaceutical Sciences Series, vol 22. Springer, Cham. https://doi.org/10.1007/978-3-319-42609-9_13

Download citation

Publish with us

Policies and ethics

Search

Navigation