Short Bowel Syndrome: Pharmacological Improvement of Bowel Function and Adaptation

  • Palle Bekker JeppesenEmail author


By presenting the pathophysiological changes in intestinal absorption following intestinal resection, the basis for pharmacological improvement of bowel function and adaptation is provided. In this chapter, the patient and treatment effect heterogeneity regarding conventional pharmacological and newer mediators of intestinal adaptation in short bowel syndrome (SBS) patients is presented. The more frequent use of metabolic balance studies to document treatment effects is advocated in the clinical setting in order to ensure the long-term clinical efficacy in the individual patients. Centres prescribing the newer hormonal mediators of intestinal adaptation should have the ability and the facilities to objectively evaluate and balance the benefit and clinical meaningfulness of the interventions versus the inconveniences, adverse effects, potential risks and cost.


Parenteral Support Short Bowel Syndrome Faecal Excretion Intestinal Failure Intestinal Adaptation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Abd. Dist

Abdominal distension

Abd. Pain

Abdominal pain


Twice daily


Crohn’s Disease


End jejunostomy or ileostomy


Growth hormone




Glucagon-like peptide




High carbohydrate low fat


Home parenteral nutrition


Intestinal failure


Intestinal insufficiency


Ileorectal anastomosis


Ileotransverse anastomosis


Jejuno-rectal anastomosis




Not measured


Not reported




Once daily


Open-label case series


Oral rehydration solutions


Proton-pump inhibitor


Parenteral support


Randomised controlled trial


Small bowel


Short bowel syndrome


Three times daily






Compared to baseline


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© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Department of GastroenterologyRigshospitaletCopenhagenDenmark

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