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Stable Plant Food Allergens I: Lipid-Transfer Proteins

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Molecular Allergy Diagnostics

Abstract

Lipid-transfer proteins (LTPs) exist in all branches of the plant kingdom (panallergens) and are able to induce both IgE sensitization and allergic reactions of different severities, including anaphylaxis. The allergens have a molecular weight of 6–10 kDa and show both high thermal and proteolytic stability. In addition to foods (fruits and vegetables), LTPs can also be found in pollen. Sensitization toward LTPs seems to occur via food intake; the clinical relevance of cross-reactivities to pollen-derived LTPs is still unclear. Allergic reactions to LTPs occur predominantly in the Mediterranean areas and are rare in Northern and Central Europe. In Southern Europe IgE reactivity to peach LTP (Pru p 3) is frequently diagnosed. For this reason Pru p 3 is used as a marker allergen. For practical clinical issues, the improvement of allergy diagnosis (by component-resolved methods) has priority over the avoidance of LTPs in allergy-causing foods from the diet. At present, allergen-specific immunotherapy is not available.

This article is based on a publication of the authors published in 2011 in the Allergo Journal (Petersen A, Kleine-Tebbe J, Scheurer S (2011): Stabile pflanzliche Nahrungsmittelallergene – Lipid-Transfer-Proteine. Allergo J 20: 384–386) which has now been updated, extended, and translated as a book chapter.

The authors gratefully thank Dr. Stefan Schülke, PhD, Paul-Ehrlich-Institute, Research Group Molecular Allergology, Langen, Germany, for his initial English translation and Dr. Steve Love, PhD, Laguna Niguel, CA, USA, for reading the manuscript, his helpful suggestions, and his final editorial assistance.

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Authors and Affiliations

  1. Research Center Borstel, Borstel, Germany

    A. Petersen PhD

  2. Allergy & Asthma Center Westend, Outpatient Clinic Hanf, Ackermann & Kleine-Tebbe, Berlin, Germany

    J. Kleine-Tebbe MD, Prof.

  3. Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen, Germany

    S. Scheurer PhD, Assoc Prof.

Authors
  1. A. Petersen PhD
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  2. J. Kleine-Tebbe MD, Prof.
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  3. S. Scheurer PhD, Assoc Prof.
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Correspondence to A. Petersen PhD .

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Editors and Affiliations

  1. Professor of Dermatology and Allergology, Allergy and Asthma Center Westend Outpatient Clinic Hanf, Ackermann and Kleine-Tebbe, Berlin, Germany

    Jörg Kleine-Tebbe

  2. Professor of Dermatology and Allergology Chairman of the Department of Dermatology and Allergology, University Medical Center Gießen and Marburg Campus Gießen Justus Liebig University Gießen, Gießen, Germany

    Thilo Jakob

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Petersen, A., Kleine-Tebbe, J., Scheurer, S. (2017). Stable Plant Food Allergens I: Lipid-Transfer Proteins. In: Kleine-Tebbe, J., Jakob, T. (eds) Molecular Allergy Diagnostics. Springer, Cham. https://doi.org/10.1007/978-3-319-42499-6_4

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  • DOI: https://doi.org/10.1007/978-3-319-42499-6_4

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