Abstract
The following substances also have a long traditional history of use, however not necessarily in the treatment of anxiety. These herbs have been included as they have demonstrated some clinical evidence and may be considered as potential treatments for anxiety. It is recommended that future studies further investigate these substances in order to determine their efficacy in the treatment of anxiety.
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Milk thistle (Silybum marianum)
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Iranian borage (Echium amoenum)
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Bitter orange (Citrus aurantium)
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Echinacea (Echinacea spp.)
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References
Paul A, Cox PA. An ethnobotanical survey of the uses for Citrus aurantium (Rutaceae) in Haiti. Econ Bot. 1995;49(3):249–56.
Carvalho-Freitas MIR, Costa M. Anxiolytic and sedative effects of extracts and essential oil from Citrus Aurantium L. Biol Pharm Bull. 2002;25(12):1629–33.
Goes TC, Antunes FD, Alves PB, Teixeira-Silva F. Effect of sweet orange aroma on experimental anxiety in humans. J Altern Complement Med. 2012;18(8):798–804.
Namazi M, Akbari SAA, Mojab F, Talebi A, Majd HA, Jannesaria S. Effects of Citrus Aurantium (Bitter Orange) on the severity of first-stage labor pain. Iran J Pharm Res. 2014;13(3):1011–8.
Namazi M, Amir Ali Akbari S, Mojab F, Talebi A, Alavi Majd H, Jannesari S. Aromatherapy with Citrus aurantium oil and anxiety during the first stage of labor. Iran Red Crescent Med J. 2014;16(6):e18371.
Cho MY, Min ES, Hur MH, Lee MS. Effects of aromatherapy on the anxiety, vital signs, and sleep quality of percutaneous coronary intervention patients in intensive care units. Evid Based Complement Alternat Med eCAM. 2013;2013:381381.
Stohs SJ, Preuss HG, Shara M. A review of the human clinical studies involving Citrus aurantium (bitter orange) extract and its primary protoalkaloid p-synephrine. Int J Med Sci. 2012;9(7):527–38.
Costa CA, Cury TC, Cassettari BO, Takahira RK, Flório JC, Costa M. Citrus aurantium L. essential oil exhibits anxiolytic- like activity mediated by 5-HT1A-receptors andreduces cholesterol after repeated oral treatment. BMC Complementary Altern Med. 2013;13(42):1–10.
Pultrini Ade M, Galindo LA, Costa M. Effects of the essential oil from Citrus aurantium L. in experimental anxiety models in mice. Life Sci. 2006;78(15):1720–5.
Leite MP, Fassin Jr J, Baziloni F, Almeida RN, Mattei R, Leite JR. Behavioral effects of essential oil of Citrus aurantium L. inhalation in rats. Braz J Pharmacognosy. 2008;18(Supp):661–6.
Khosravi M, Khakpour S, Adibi L, Jahromy MH. A study of the effect of Citrus aurantium L. essential oil on anxiety and its interaction with GABAergic pathways in male mice. J Behav Brain Sci. 2014;04(10):470–6.
Akhlaghi M, Shabanian G, Rafieian-Kopaei M, Parvin N, Saadat M. Citrus aurantium blossom and preoperative anxiety. RevBrasAnestesiol. 2011;61(6):702–12.
Haller J, Freund TF, Pelczer KG, Furedi J, Krecsak L, Zambori J. The anxiolytic potential and psychotropic side effects of an echinacea preparation in laboratory animals and healthy volunteers. Phytother Res. 2013;27(1):54–61.
Kindscher K. Ethnobotany of purple coneflower (Echinacea angustifolia, Astraceae) and other echinacea species. Econ Bot. 1989;43(4):498–507.
Woelkart K, Baur R. The role of alkamides as an active principle of echinacea. Planta Med. 2007;73:615–23.
Tambaro S, Bortolato M. Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives. CNS Drugs Discov. 2012;7(1):25–40.
Hájos N, Holderith N, Németh B, Papp OI, Szabó GG, Zemankovics R, et al. The effects of an echinacea preparation on synaptic transmission and the firing properties of CA1 pyramidal cells in the hippocampus. Phytother Res. 2012;26(3):354–62.
Haller J, Hohmann J, Freund TF. The effect of Echinacea preparations in three laboratory tests of anxiety: comparison with chlordiazepoxide. Phytother Res. 2010;24(11):1605–13.
Rabbani M, Sajjadi SE, Khalili S. A lack of tolerance to the anxiolytic action of Echium amoenum. Res Pharm Sci. 2011;6(2):101–6.
Gholamzadeh S, Zare S, Ikhanipoor M. Anxiolytic effect of Echium amoenum during different treatment courses. Res Biol Sci. 2008;3(2):176–8.
Gholamzadeh S, Zare S, Ilkhanipoor M. Evaluation of the anxiolytic effect of Echium amoenum petalsextract, during chronic treatment in rat. Res Pharm Sci. 2007;2(2):91–5.
Rabbani M, Sajjadi SE, Vaseghi G, Jafarian A. Anxiolytic effects of Echium amoenum on the elevated plus-maze model of anxiety in mice. Fitoterapia. 2004;75(5):457–64.
Shafaghi B, Naderi N, Tahmasb L, Kamalinejad M. Anxiolytic effect of Echium amoenum L. in Mice. Iran J Pharm Res. 2002;1:37–41.
Sayyah M, Boostani H, Pakseresht S, Malaieri A. Efficacy of aqueous extract of Echium amoenum in treatment of obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(8):1513–6.
Sayyah M, Siahpoosh A, Khalili H, Malaieri A, Samaee H. A double-blind, placebo-controlled study of the aqueous extract ofEchium amoenum for patients with general anxiety disorder. Iran J Pharm Res. 2012;11(2):697–701.
Sayyah M, Sayyah M, Kamalinejad M. A preliminary randomized double blind clinical trial on the efficacy ofaqueous extract of Echium amoenum in the treatment of mild to moderatemajor depression. Prog Neuro-Psychopharmacol Biol Psychiatry. 2006;30:166–9.
Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. Phytother Res. 2010;24(10):1423–32.
Bahmani M, Shirzad H, Rafieian S, Rafieian-Kopaei M. Silybum marianum: beyond Hepatoprotection. J Evid Based Complementary Altern Med. 2015;20(4):292–301.
Felter HW, Lloyd JU. King’s American dispensatory. 1898.
Mosaddegh M, Naghibi F, Moazzeni H, Pirani A, Esmaeili S. Ethnobotanical survey of herbal remedies traditionally used in Kohghiluyeh va Boyer Ahmad province of Iran. J Ethnopharmacol. 2012;141(1):80–95.
Kroll DJ, Shaw HS, Oberlies NH. Milk thistle nomenclature: why it matters in cancer research and pharmacokinetic studies. Integr Cancer Ther. 2007;6(2):110–9.
Osuchowski MF, Johnson VJ, He Q, Sharma RP. Alterations in regional brain neurotransmitters by silymarin, a natural antioxidant flavonoid mixture, in BALB/c mice. Pharmaceutical Biol. 2004;42(4–5):384–9.
Lu P, Mamiya T, Lu L, Mouri A, Niwa M, Kim HC, et al. Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatment. Behav Brain Res. 2010;207(2):387–93.
Mazzio EA, Harris N, Soliman KFA. Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells. Planta Medica. 1998;64(7):603–6.
Solati J, Yaghmaei P, Mohammdadi K. Role of the 5-HT1A serotonergic system in anxiolytic-like effects of Silymarin. Neurophysiol. 2012;44(1):49–55.
Sayyah M, Boostani H, Pakseresht S, Malayeri A. Comparison of Silybum marianum (L.) Gaertn. with fluoxetine in the treatment of obsessive−compulsive disorder. Prog Neuro-Psychopharmacol Biol Psychiatry. 2010;34(2):362–5.
Gordon A, Hobbs DA, Bowden DS, Bailey MJ, Mitchell J, Francis AJP, et al. Effects of Silybum marianum on serum hepatitis C virus RNA, alanine aminotransferase levels and well-being in patients with chronic hepatitis C. J Gastroenterol Hepatol. 2006;21(1):275–80.
Grant JE, Odlaug BL. Silymarin treatment of obsessive-compulsive spectrum disorders. J Clin Psychopharmacol. 2015;35(3):340–2.
Ardjomand-Woelkart K, Bauer R. Review and assessment of medicinal safety data of orally used Echinacea preparations. Planta Medica. 2016;82(01/02):17–31.
Sarris J, Ng C, Schweitzer I. “Omic” genetic technologies for herbal medicines in psychiatry. Phytother Res. 2011;26:522–7.
Ulrich-Merzenich G, Zeitler H, Jobst D, Panek D, Vetter H, Wagner H. Application of the “-Omic-” technologies in phytomedicine. Phytomedicine. 2007;14(1):70–82.
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McIntyre, E., Camfield, D.A., Sarris, J. (2017). Potential Herbal Anxiolytics. In: Camfield, D., McIntyre, E., Sarris, J. (eds) Evidence-Based Herbal and Nutritional Treatments for Anxiety in Psychiatric Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-42307-4_8
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