Abstract
Entities in this category are characterized by the absence of significant epidermal change and the presence of an inflammatory infiltrate that is largely restricted to the superficial, or superficial and deep dermis around blood vessels. Not infrequently, there may be some overlap with the superficial, and superficial and deep perivascular patterns. To the consternation of many pathologists, initial perusal of a skin biopsy demonstrating a superficial or superficial and deep inflammatory infiltrate in the absence of spongiosis or other epidermal change may seem like an exercise in diagnostic futility. However, by paying close attention to the composition and distribution of the inflammatory infiltrate, one can apply an organized approach to this clinically diverse group of disorders. This chapter will cover most of the important and common diseases having the superficial and deep pattern of inflammation.
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Selected References
Ackerman AB, Jones RE. Making chronic nonspecific dermatitis specific. Am J Dermatopathol. 1985;7(4):307–23.
Barnhill RB, Busam KJ. Vascular diseases. In: Elder D, Elenitsas R, Jaworsky C, Johnson Jr B, editors. Lever’s histopathology of the skin. 8th ed. Philadelphia: Lippincott-Raven; 1997.
Barzilai A, Shipiro D, Shapiro D, Goldberg I, Yacob-Hirsch Y, Diaz-Cascajo C, et al. Insect bite reaction in patients with hematologic malignant neoplasms. Arch Dermatol. 1999;135(12):1503–7.
Cepeda LT, Pieretti M, Chapman SF, Horenstein MG. CD30-positive atypical lymphoid cells in common non-neoplastic cutaneous infiltrates rich in neutrophils and eosinophils. Am J Surg Pathol. 2003;27(7):912–8.
El Shabrawi-Caelen L, Kerl H, Cerroni L. Lymphomatoid papulosis: reappraisal of clinicopathologic presentation and classification into subtypes A, B, and C. Arch Dermatol. 2004;140(4):441–7.
Flores-Bozo LR, Dominguez-Cherit J, Charli-Joseph Y. Angioinvasive lymphomatoid papulosis type E. Case report and review of the literature. J Am Acad Dermatol. 2015;72(5):AB81.
Fung MA. The clinical and histologic spectrum of “dermal hypersensitivity reactions”, a nonspecific histologic diagnosis that is not very useful in clinical practice, and the concept of a “dermal hypersensitivity reaction pattern”. J Am Acad Dermatol. 2002;47(6):898–907.
Gallardo F, Barranco C, Toll A, Pujol RM. CD30 antigen expression in cutaneous inflammatory infiltrates of scabies: a dynamic immunophenotypic pattern that should be distinguished from lymphomatoid papulosis. J Cutan Pathol. 2002;29(6):368–73.
Magro C, Schaefer JT, Crowson A, Li J, Morrison C. Pigmented purpuric dermatosis: classification by phenotypic and molecular profiles. Am J Clin Pathol. 2007;128(2):218–29.
McQuitty F, Curry JL, Tetzlaff MT, Prieto VG, Duvic M, Torres-Cabala C. The differential diagnosis of CD8-positive (“type D”) lymphomatoid papulosis. J Cutan Pathol. 2014;41(2):1018–23.
Mihm M, Clark W, Reed R, Caruso M. Mast cell infiltrates of the skin and the mastocytosis syndrome. Hum Pathol. 1973;4(2):231–9.
Patterson JW. Weedon’s skin pathology. 4th ed. New York: Churchill Livingstone/Elsevier; 2016.
Soter NA. The skin in mastocytosis. J Invest Dermatol. 1991;96(3 Suppl):32S–8. discussion 38S–39S, 50S–65S.
Wieser I, Chee Won O, Rakshshandra T, Duvic M. Lymphomatoid papulosis: treatment response and associated lymphomas in a study of 180 patients. J Am Acad Dermatol. 2016;74(1):59–67.
Willemze R, Meijer CJ. Primary cutaneous CD30-positive lymphoproliferative disorders. Hematol Oncol Clin North Am. 2003;17(6):1319–32. vii–viii.
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Billings, S.D., Cotton, J. (2016). Perivascular Dermatitis. In: Inflammatory Dermatopathology. Springer, Cham. https://doi.org/10.1007/978-3-319-41897-1_5
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DOI: https://doi.org/10.1007/978-3-319-41897-1_5
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