Biochemistry of Coenzyme Q10

  • Gian Paolo Littarru
  • Francesca Bruge
  • Luca TianoEmail author
Part of the Trends in Andrology and Sexual Medicine book series (TASM)


Human coenzyme Q (CoQ10) or ubiquinone is mainly known for its bioenergetic role as a proton and electron carrier in the inner mitochondrial membrane and is also an endogenous lipophilic antioxidant, ubiquitous in biological membranes. It is also present in plasma lipoproteins, where it plays a well-recognized antioxidant role. More recently coenzyme Q10 was also shown to affect gene expression by modulating the intracellular redox status. Its involvement in many cellular and extracellular functions suggests that its use as a food supplement could be beneficial in conditions associated with increased oxidative stress underlying different pathological conditions. In reproductive biology, CoQ10 has been shown to play a role in fertility of both males and females.


Sperm Motility Seminal Plasma Inner Cell Mass Mitochondrial Bioenergetic Dimethylallyl Diphosphate 
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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  • Gian Paolo Littarru
    • 1
  • Francesca Bruge
    • 1
  • Luca Tiano
    • 1
    Email author
  1. 1.Department of Clinical and Dental Sciences – Biochemistry SectionPolytechnic University of MarcheAnconaItaly

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