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Temporomandibular Disorder Comorbidity

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Comorbidities in Headache Disorders

Part of the book series: Headache ((HEAD))

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Abstract

Temporomandibular disorders (TMD) are conceptualized as a group of diverse conditions related to the jaw muscles, temporomandibular joint (TMJ) and related tissues and may be associated with pain, limitations in jaw movements and noises in the TMJ. It is generally agreed that TMD just represents an umbrella term, and intensive work has been devoted to establish specific criteria for subsets of TMDs which are both reliable and valid. This has been achieved with the Diagnostic Criteria for TMD (DC/TMD) (Schiffman et al., J Oral Facial Pain Headache 28(1):6–27, 2014), and all main diagnoses now have known reliability, sensitivity and specificity values which are unique for any pain classification system. One of the new diagnoses in the DC/TMD is headache attributed to TMD (HATMD) (Schiffman et al., Cephalalgia 32(9):683–692, 2012; Schiffman et al., J Oral Facial Pain Headache 28(1):6–27, 2014) which clearly indicates that there is a close overlap between some of the many headache types and some of the painful TMDs. It may be useful from a clinical perspective to recognize some of the similarities in clinical presentation but also to try to identify potential differences in symptomatology as well as underlying pain mechanisms and management. This chapter will first provide an overview of the clinical presentations and overlaps between TMD and headache. Some of the basic mechanisms related to nociception from musculoskeletal tissues, peripheral and central sensitization and endogenous inhibitory controls will then be discussed with particular reference to TMDs.

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References

  1. The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629–808.

    Google Scholar 

  2. Abboud J, Marchand AA, Sorra K, Descarreaux M. Musculoskeletal physical outcome measures in individuals with tension-type headache: a scoping review. Cephalalgia. 2013;33(16):1319–36.

    Article  PubMed  Google Scholar 

  3. Alstergren P, Ernberg M, Kvarnstrom M, Kopp S. Interleukin-1beta in synovial fluid from the arthritic temporomandibular joint and its relation to pain, mobility, and anterior open bite. J Oral Maxillofac Surg Off J Am Assoc Oral Maxillofac Surg. 1998;56(9):1059–65; discussion 1066.

    Article  CAS  Google Scholar 

  4. Ashina M, Bendtsen L, Jensen R, Lassen LH, Sakai F, Olesen J. Possible mechanisms of action of nitric oxide synthase inhibitors in chronic tension-type headache. Brain J Neurol. 1999;122(Pt 9):1629–35.

    Article  Google Scholar 

  5. Ashina M, Stallknecht B, Bendtsen L, Pedersen JF, Schifter S, Galbo H, Olesen J. Tender points are not sites of ongoing inflammation -in vivo evidence in patients with chronic tension-type headache. Cephalalgia. 2003;23(2):109–16.

    Article  CAS  PubMed  Google Scholar 

  6. Ashina S, Babenko L, Jensen R, Ashina M, Magerl W, Bendtsen L. Increased muscular and cutaneous pain sensitivity in cephalic region in patients with chronic tension-type headache. Eur J Neurol. 2005;12(7):543–9.

    Article  CAS  PubMed  Google Scholar 

  7. Ashina S, Bendtsen L, Ashina M, Magerl W, Jensen R. Generalized hyperalgesia in patients with chronic tension-type headache. Cephalalgia. 2006;26(8):940–8.

    Article  CAS  PubMed  Google Scholar 

  8. Ayesh EE, Jensen TS, Svensson P. Hypersensitivity to mechanical and intra-articular electrical stimuli in persons with painful temporomandibular joints. J Dent Res. 2007;86(12):1187–92.

    Article  CAS  PubMed  Google Scholar 

  9. Balasubramaniam R, de Leeuw R, Zhu H, Nickerson RB, Okeson JP, Carlson CR. Prevalence of temporomandibular disorders in fibromyalgia and failed back syndrome patients: a blinded prospective comparison study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104(2):204–16.

    Article  PubMed  Google Scholar 

  10. Ballegaard V, Thede-Schmidt-Hansen P, Svensson P, Jensen R. Are headache and temporomandibular disorders related? A blinded study. Cephalalgia. 2008;28(8):832–41.

    Article  CAS  PubMed  Google Scholar 

  11. Baron R, Forster M, Binder A. Subgrouping of patients with neuropathic pain according to pain-related sensory abnormalities: a first step to a stratified treatment approach. Lancet Neurol. 2012;11(11):999–1005.

    Article  PubMed  Google Scholar 

  12. Bendtsen L. Central sensitization in tension-type headache – possible pathophysiological mechanisms. Cephalalgia. 2000;20(5):486–508.

    Article  CAS  PubMed  Google Scholar 

  13. Bendtsen L, Fernandez-de-la-Penas C. The role of muscles in tension-type headache. Curr Pain Headache Rep. 2011;15(6):451–8.

    Article  PubMed  Google Scholar 

  14. Bendtsen L, Jensen R. Tension-type headache: the most common, but also the most neglected, headache disorder. Curr Opin Neurol. 2006;19(3):305–9.

    PubMed  Google Scholar 

  15. Bevilaqua Grossi D, Lipton RB, Bigal ME. Temporomandibular disorders and migraine chronification. Curr Pain Headache Rep. 2009;13(4):314–8.

    Article  PubMed  Google Scholar 

  16. Boyer N, Dallel R, Artola A, Monconduit L. General trigeminospinal central sensitization and impaired descending pain inhibitory controls contribute to migraine progression. Pain. 2014;155(7):1196–205.

    Article  PubMed  Google Scholar 

  17. Buchgreitz L, Lyngberg AC, Bendtsen L, Jensen R. Frequency of headache is related to sensitization: a population study. Pain. 2006;123(1–2):19–27.

    Article  CAS  PubMed  Google Scholar 

  18. Buchgreitz L, Lyngberg AC, Bendtsen L, Jensen R. Increased pain sensitivity is not a risk factor but a consequence of frequent headache: a population-based follow-up study. Pain. 2008;137(3):623–30.

    Article  CAS  PubMed  Google Scholar 

  19. Burstein R, Cutrer MF, Yarnitsky D. The development of cutaneous allodynia during a migraine attack clinical evidence for the sequential recruitment of spinal and supraspinal nociceptive neurons in migraine. Brain J Neurol. 2000;123(Pt 8):1703–9.

    Article  Google Scholar 

  20. Burstein R, Jakubowski M, Garcia-Nicas E, Kainz V, Bajwa Z, Hargreaves R, Becerra L, Borsook D. Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol. 2010;68(1):81–91.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Burstein R, Yarnitsky D, Goor-Aryeh I, Ransil BJ, Bajwa ZH. An association between migraine and cutaneous allodynia. Ann Neurol. 2000;47(5):614–24.

    Article  CAS  PubMed  Google Scholar 

  22. Cady RJ, Glenn JR, Smith KM, Durham PL. Calcitonin gene-related peptide promotes cellular changes in trigeminal neurons and glia implicated in peripheral and central sensitization. Mol Pain. 2011;7:94.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Cairns B. Pathophysiology of TMD pain–basic mechanisms and their implications for pharmacotherapy. J Oral Rehabil. 2010;37(6):391–410.

    Article  CAS  PubMed  Google Scholar 

  24. Cairns BE, Svensson P, Wang K, Castrillon E, Hupfeld S, Sessle BJ, Arendt-Nielsen L. Ketamine attenuates glutamate-induced mechanical sensitization of the masseter muscle in human males. Exp Brain Res. 2006;169(4):467–72.

    Article  CAS  PubMed  Google Scholar 

  25. Cairns BE, Svensson P, Wang K, Hupfeld S, Graven-Nielsen T, Sessle BJ, Berde CB, Arendt-Nielsen L. Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle. J Neurophysiol. 2003;90(4):2098–105.

    Article  CAS  PubMed  Google Scholar 

  26. Carli G, Suman AL, Biasi G, Marcolongo R. Reactivity to superficial and deep stimuli in patients with chronic musculoskeletal pain. Pain. 2002;100(3):259–69.

    Article  PubMed  Google Scholar 

  27. Cathcart S, Winefield AH, Lushington K, Rolan P. Noxious inhibition of temporal summation is impaired in chronic tension-type headache. Headache. 2010;50(3):403–12.

    Article  PubMed  Google Scholar 

  28. Chun YH, Frank D, Lee JS, Zhang Y, Auh QS, Ro JY. Peripheral AMPA receptors contribute to muscle nociception and c-fos activation. Neurosci Res. 2008;62(2):97–104.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Clauw DJ. Fibromyalgia and related conditions. Mayo Clin Proc. 2015;90(5):680–92.

    Article  PubMed  Google Scholar 

  30. Defrin R, Riabinin M, Feingold Y, Schreiber S, Pick CG. Deficient pain modulatory systems in patients with mild traumatic brain and chronic post-traumatic headache: implications for its mechanism. J Neurotrauma. 2015;32(1):28–37.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Della Vedova C, Cathcart S, Dohnalek A, Lee V, Hutchinson MR, Immink MA, Hayball J. Peripheral interleukin-1β levels are elevated in chronic tension-type headache patients. Pain Res Manag: J Can Pain Soc. 2013;18(6):301–6.

    Article  Google Scholar 

  32. Diatchenko L, Anderson AD, Slade GD, Fillingim RB, Shabalina SA, Higgins TJ, Sama S, Belfer I, Goldman D, Max MB, Weir BS, Maixner W. Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am J Med Genet B Neuropsychiatr Genet Offic Publ Int Soc Psychiatr Genet. 2006;141b(5):449–62.

    Article  CAS  Google Scholar 

  33. Diatchenko L, Nackley AG, Slade GD, Bhalang K, Belfer I, Max MB, Goldman D, Maixner W. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain. 2006;125(3):216–24.

    Article  CAS  PubMed  Google Scholar 

  34. Diatchenko L, Slade GD, Nackley AG, Bhalang K, Sigurdsson A, Belfer I, Goldman D, Xu K, Shabalina SA, Shagin D, Max MB, Makarov SS, Maixner W. Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet. 2005;14(1):135–43.

    Article  CAS  PubMed  Google Scholar 

  35. Drummond PD, Knudsen L. Central pain modulation and scalp tenderness in frequent episodic tension-type headache. Headache. 2011;51(3):375–83.

    Article  PubMed  Google Scholar 

  36. Ekberg EC, Nilner M. Treatment outcome of short- and long-term appliance therapy in patients with TMD of myogenous origin and tension-type headache. J Oral Rehabil. 2006;33(10):713–21.

    Article  CAS  PubMed  Google Scholar 

  37. Erdal ME, Herken H, Yilmaz M, Bayazit YA. Association of the T102C polymorphism of 5-HT2A receptor gene with aura in migraine. J Neurol Sci. 2001;188(1–2):99–101.

    Article  CAS  PubMed  Google Scholar 

  38. Fernandez-de-Las-Penas C, Alonso-Blanco C, Cuadrado ML, Gerwin RD, Pareja JA. Myofascial trigger points and their relationship to headache clinical parameters in chronic tension-type headache. Headache. 2006;46(8):1264–72.

    Article  PubMed  Google Scholar 

  39. Fernandez-de-las-Penas C, Alonso-Blanco C, Cuadrado ML, Gerwin RD, Pareja JA. Trigger points in the suboccipital muscles and forward head posture in tension-type headache. Headache. 2006;46(3):454–60.

    Article  PubMed  Google Scholar 

  40. Fernandez-de-Las-Penas C, Alonso-Blanco C, Cuadrado ML, Pareja JA. Myofascial trigger points in the suboccipital muscles in episodic tension-type headache. Man Ther. 2006;11(3):225–30.

    Article  PubMed  Google Scholar 

  41. Fernandez-de-las-Penas C, Ambite-Quesada S, Rivas-Martinez I, Ortega-Santiago R, de-la-Llave-Rincon AI, Fernandez-Mayoralas DM, Pareja JA. Genetic contribution of catechol-O-methyltransferase polymorphism (Val158Met) in children with chronic tension-type headache. Pediatr Res. 2011;70(4):395–9.

    Article  CAS  PubMed  Google Scholar 

  42. Fernandez-de-Las-Penas C, Cuadrado ML, Arendt-Nielsen L, Ge HY, Pareja JA. Increased pericranial tenderness, decreased pressure pain threshold, and headache clinical parameters in chronic tension-type headache patients. Clin J Pain. 2007;23(4):346–52.

    Article  PubMed  Google Scholar 

  43. Fernandez-de-Las-Penas C, Cuadrado ML, Pareja JA. Myofascial trigger points, neck mobility, and forward head posture in episodic tension-type headache. Headache. 2007;47(5):662–72.

    Article  PubMed  Google Scholar 

  44. Fernandez-de-las-Penas C, Galan-del-Rio F, Fernandez-Carnero J, Pesquera J, Arendt-Nielsen L, Svensson P. Bilateral widespread mechanical pain sensitivity in women with myofascial temporomandibular disorder: evidence of impairment in central nociceptive processing. J Pain Offic J Am Pain Soc. 2009;10(11):1170–8.

    Article  Google Scholar 

  45. Fernandez-de-Las-Penas C, Ortega-Santiago R, Cuadrado ML, Lopez-de-Silanes C, Pareja JA. Bilateral widespread mechanical pain hypersensitivity as sign of central sensitization in patients with cluster headache. Headache. 2011;51(3):384–91.

    Article  PubMed  Google Scholar 

  46. Freund BJ, Schwartz M. Relief of tension-type headache symptoms in subjects with temporomandibular disorders treated with botulinum toxin-A. Headache. 2002;42(10):1033–7.

    Article  PubMed  Google Scholar 

  47. Garrett PH, Sarlani E, Grace EG, Greenspan JD. Chronic temporomandibular disorders are not necessarily associated with a compromised endogenous analgesic system. J Orofac Pain. 2013;27(2):142–50.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Glaros AG, Urban D, Locke J. Headache and temporomandibular disorders: evidence for diagnostic and behavioural overlap. Cephalalgia. 2007;27(6):542–9.

    Article  CAS  PubMed  Google Scholar 

  49. Gomes MB, Guimaraes JP, Guimaraes FC, Neves AC. Palpation and pressure pain threshold: reliability and validity in patients with temporomandibular disorders. Cranio J Craniomandibular Pract. 2008;26(3):202–10.

    Google Scholar 

  50. Goncalves DA, Camparis CM, Speciali JG, Castanharo SM, Ujikawa LT, Lipton RB, Bigal ME. Treatment of comorbid migraine and temporomandibular disorders: a factorial, double-blind, randomized, placebo-controlled study. J Orofac Pain. 2013;27(4):325–35.

    Article  PubMed  Google Scholar 

  51. Goncalves DA, Camparis CM, Speciali JG, Franco AL, Castanharo SM, Bigal ME. Temporomandibular disorders are differentially associated with headache diagnoses: a controlled study. Clin J Pain. 2011;27(7):611–5.

    Article  PubMed  Google Scholar 

  52. Goncalves MC, Florencio LL, Chaves TC, Speciali JG, Bigal ME, Bevilaqua-Grossi D. Do women with migraine have higher prevalence of temporomandibular disorders? Braz J Phys Ther. 2013;17(1):64–8.

    Article  PubMed  Google Scholar 

  53. Graven-Nielsen T, Wodehouse T, Langford RM, Arendt-Nielsen L, Kidd BL. Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement. Arthritis Rheum. 2012;64(9):2907–16.

    Article  CAS  PubMed  Google Scholar 

  54. Hagen K, Pettersen E, Stovner LJ, Skorpen F, Zwart JA. The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT Study. J Headache Pain. 2006;7(2):70–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Hartung JE, Ciszek BP, Nackley AG. Beta2- and beta3-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines. Pain. 2014;155(7):1346–55.

    Article  CAS  PubMed  Google Scholar 

  56. King CD, Wong F, Currie T, Mauderli AP, Fillingim RB, Riley 3rd JL. Deficiency in endogenous modulation of prolonged heat pain in patients with Irritable Bowel Syndrome and Temporomandibular Disorder. Pain. 2009;143(3):172–8.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Kocer A, Kocer E, Memisogullari R, Domac FM, Yuksel H. Interleukin-6 levels in tension headache patients. Clin J Pain. 2010;26(8):690–3.

    PubMed  Google Scholar 

  58. Kosek E, Ordeberg G. Lack of pressure pain modulation by heterotopic noxious conditioning stimulation in patients with painful osteoarthritis before, but not following, surgical pain relief. Pain. 2000;88(1):69–78.

    Article  CAS  PubMed  Google Scholar 

  59. Kothari SF, Baad-Hansen L, Oono Y, Svensson P. Somatosensory assessment and conditioned pain modulation in temporomandibular disorders pain patients. Pain. 2015;156(12):2545–55.

    Article  PubMed  Google Scholar 

  60. Lai TH, Protsenko E, Cheng YC, Loggia ML, Coppola G, Chen WT. Neural plasticity in common forms of chronic headaches. Neural Plast. 2015;2015:205985.

    PubMed  PubMed Central  Google Scholar 

  61. Lam DK, Sessle BJ, Hu JW. Glutamate and capsaicin effects on trigeminal nociception II: activation and central sensitization in brainstem neurons with deep craniofacial afferent input. Brain Res. 2009;1253:48–59.

    Article  CAS  PubMed  Google Scholar 

  62. Latremoliere A, Woolf CJ. Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain Offic J Am Pain Soc. 2009;10(9):895–926.

    Article  Google Scholar 

  63. Leblebici B, Pektas ZO, Ortancil O, Hurcan EC, Bagis S, Akman MN. Coexistence of fibromyalgia, temporomandibular disorder, and masticatory myofascial pain syndromes. Rheumatol Int. 2007;27(6):541–4.

    Article  PubMed  Google Scholar 

  64. Lee YC, Lu B, Edwards RR, Wasan AD, Nassikas NJ, Clauw DJ, Solomon DH, Karlson EW. The role of sleep problems in central pain processing in rheumatoid arthritis. Arthritis Rheum. 2013;65(1):59–68.

    Article  PubMed  PubMed Central  Google Scholar 

  65. Liljestrom MR, Le Bell Y, Anttila P, Aromaa M, Jamsa T, Metsahonkala L, Helenius H, Viander S, Jappila E, Alanen P, Sillanpaa M. Headache children with temporomandibular disorders have several types of pain and other symptoms. Cephalalgia. 2005;25(11):1054–60.

    Article  PubMed  Google Scholar 

  66. Lindstedt F, Berrebi J, Greayer E, Lonsdorf TB, Schalling M, Ingvar M, Kosek E. Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene. PLoS One. 2011;6(3):e18252.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Lipton RB, Bigal ME, Ashina S, Burstein R, Silberstein S, Reed ML, Serrano D, Stewart WF. Cutaneous allodynia in the migraine population. Ann Neurol. 2008;63(2):148–58.

    Article  PubMed  PubMed Central  Google Scholar 

  68. Lovati C, Giani L, Castoldi D, Mariotti D’Alessandro C, DeAngeli F, Capiluppi E, D’Amico D, Mariani C. Osmophobia in allodynic migraineurs: cause or consequence of central sensitization? Neurol Sci. 2015;36 Suppl 1:145–7.

    Article  PubMed  Google Scholar 

  69. Lukacs M, Haanes KA, Majlath Z, Tajti J, Vecsei L, Warfvinge K, Edvinsson L. Dural administration of inflammatory soup or Complete Freund’s Adjuvant induces activation and inflammatory response in the rat trigeminal ganglion. J Headache Pain. 2015;16:564.

    Article  CAS  PubMed  Google Scholar 

  70. Maixner W, Fillingim R, Booker D, Sigurdsson A. Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain. Pain. 1995;63(3):341–51.

    Article  CAS  PubMed  Google Scholar 

  71. Marklund S, Wiesinger B, Wanman A. Reciprocal influence on the incidence of symptoms in trigeminally and spinally innervated areas. Eur J Pain. 2010;14(4):366–71.

    Article  PubMed  Google Scholar 

  72. Melo CE, Oliveira JL, Jesus AC, Maia ML, de Santana JC, Andrade LS, Quintans JD, Quintans-Junior LJ, Conti PC, Bonjardim LR. Temporomandibular disorders dysfunction in headache patients. Med Oral Patol Oral Cir Bucal. 2012;17(6):e1042–6.

    Article  PubMed  Google Scholar 

  73. Mense S. Muscle pain: mechanisms and clinical significance. Dtsch Arztebl Int. 2008;105(12):214–9.

    PubMed  PubMed Central  Google Scholar 

  74. Mense S. Algesic agents exciting muscle nociceptors. Exp Brain Res. 2009;196(1):89–100.

    Article  CAS  PubMed  Google Scholar 

  75. Michelotti A, Liguori R, Toriello M, D’Anto V, Vitale D, Castaldo G, Sacchetti L. Catechol-O-methyltransferase (COMT) gene polymorphisms as risk factor in temporomandibular disorders patients from Southern Italy. Clin J Pain. 2014;30(2):129–33.

    PubMed  Google Scholar 

  76. Nackley AG, Tan KS, Fecho K, Flood P, Diatchenko L, Maixner W. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. Pain. 2007;128(3):199–208.

    Article  CAS  PubMed  Google Scholar 

  77. Nahman-Averbuch H, Granovsky Y, Coghill RC, Yarnitsky D, Sprecher E, Weissman-Fogel I. Waning of “conditioned pain modulation”: a novel expression of subtle pronociception in migraine. Headache. 2013;53(7):1104–15.

    Article  PubMed  Google Scholar 

  78. Nilsson IM, List T, Drangsholt M. Headache and co-morbid pains associated with TMD pain in adolescents. J Dent Res. 2013;92(9):802–7.

    Article  PubMed  Google Scholar 

  79. Ojima K, Watanabe N, Narita N, Narita M. Temporomandibular disorder is associated with a serotonin transporter gene polymorphism in the Japanese population. BioPsychoSocial Med. 2007;1:3.

    Article  CAS  Google Scholar 

  80. Olesen J, Steiner T, Bousser MG, Diener HC, Dodick D, First MB, Goadsby PJ, Gobel H, Lainez MJ, Lipton RB, Nappi G, Sakai F, Schoenen J, Silberstein SD. Proposals for new standardized general diagnostic criteria for the secondary headaches. Cephalalgia. 2009;29(12):1331–6.

    Article  CAS  PubMed  Google Scholar 

  81. Oono Y, Wang K, Baad-Hansen L, Futarmal S, Kohase H, Svensson P, Arendt-Nielsen L. Conditioned pain modulation in temporomandibular disorders (TMD) pain patients. Exp Brain Res. 2014;232(10):3111–9.

    Article  PubMed  Google Scholar 

  82. Park JW, Chung JW. Inflammatory cytokines and sleep disturbance in patients with temporomandibular disorders. J Oral Facial Pain Headache. 2016;30(1):27–33.

    Article  PubMed  Google Scholar 

  83. Peck CC, Goulet JP, Lobbezoo F, Schiffman EL, Alstergren P, Anderson GC, de Leeuw R, Jensen R, Michelotti A, Ohrbach R, Petersson A, List T. Expanding the taxonomy of the diagnostic criteria for temporomandibular disorders. J Oral Rehabil. 2014;41(1):2–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  84. Pfau DB, Rolke R, Nickel R, Treede RD, Daublaender M. Somatosensory profiles in subgroups of patients with myogenic temporomandibular disorders and Fibromyalgia Syndrome. Pain. 2009;147(1–3):72–83.

    Article  PubMed  Google Scholar 

  85. Pielsticker A, Haag G, Zaudig M, Lautenbacher S. Impairment of pain inhibition in chronic tension-type headache. Pain. 2005;118(1–2):215–23.

    Article  PubMed  Google Scholar 

  86. Porreca F, Ossipov MH, Gebhart GF. Chronic pain and medullary descending facilitation. Trends Neurosci. 2002;25(6):319–25.

    Article  CAS  PubMed  Google Scholar 

  87. Potvin S, Larouche A, Normand E, de Souza JB, Gaumond I, Grignon S, Marchand S. DRD3 Ser9Gly polymorphism is related to thermal pain perception and modulation in chronic widespread pain patients and healthy controls. J Pain Off J Am Pain Soc. 2009;10(9):969–75.

    Article  CAS  Google Scholar 

  88. Rainero I, Fasano E, Rubino E, Rivoiro C, Valfre W, Gallone S, Savi L, Gentile S, Lo Giudice R, De Martino P, Dall’Omo AM, Pinessi L. Association between migraine and HLA-DRB1 gene polymorphisms. J Headache Pain. 2005;6(4):185–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Reid KI, Gracely RH, Dubner RA. The influence of time, facial side, and location on pain-pressure thresholds in chronic myogenous temporomandibular disorder. J Orofac Pain. 1994;8(3):258–65.

    CAS  PubMed  Google Scholar 

  90. Romero-Reyes M, Akerman S, Nguyen E, Vijjeswarapu A, Hom B, Dong HW, Charles AC. Spontaneous behavioral responses in the orofacial region: a model of trigeminal pain in mouse. Headache. 2013;53(1):137–51.

    Article  PubMed  Google Scholar 

  91. Russell MB, Saltyte-Benth J, Levi N. Are infrequent episodic, frequent episodic and chronic tension-type headache inherited? A population-based study of 11 199 twin pairs. J Headache Pain. 2006;7(3):119–26.

    Article  PubMed  PubMed Central  Google Scholar 

  92. Sales Pinto LM, de Carvalho JJ, Cunha CO, Dos Santos Silva R, Fiamengui-Filho JF, Rodrigues Conti PC. Influence of myofascial pain on the pressure pain threshold of masticatory muscles in women with migraine. Clin J Pain. 2013;29(4):362–5.

    Article  PubMed  Google Scholar 

  93. Sandrini G, Rossi P, Milanov I, Serrao M, Cecchini AP, Nappi G. Abnormal modulatory influence of diffuse noxious inhibitory controls in migraine and chronic tension-type headache patients. Cephalalgia. 2006;26(7):782–9.

    Article  CAS  PubMed  Google Scholar 

  94. Sarlani E, Grace EG, Reynolds MA, Greenspan JD. Sex differences in temporal summation of pain and aftersensations following repetitive noxious mechanical stimulation. Pain. 2004;109(1–2):115–23.

    Article  PubMed  Google Scholar 

  95. Sato H, Saisu H, Muraoka W, Nakagawa T, Svensson P, Wajima K. Lack of temporal summation but distinct aftersensations to thermal stimulation in patients with combined tension-type headache and myofascial temporomandibular disorder. J Orofac Pain. 2012;26(4):288–95.

    PubMed  Google Scholar 

  96. Schiffman E, Ohrbach R, List T, Anderson G, Jensen R, John MT, Nixdorf D, Goulet JP, Kang W, Truelove E, Clavel A, Fricton J, Look J. Diagnostic criteria for headache attributed to temporomandibular disorders. Cephalalgia. 2012;32(9):683–92.

    Article  PubMed  PubMed Central  Google Scholar 

  97. Gaul C, Goldberg LJ, Haythornthwaite JA, Hollender L, Jensen R, John MT, De Laat A, de Leeuw R, Maixner W, van der Meulen M, Murray GM, Nixdorf DR, Palla S, Petersson A, Pionchon P, Smith B, Visscher CM, Zakrzewska J, Dworkin SF. Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) for Clinical and Research Applications: recommendations of the International RDC/TMD Consortium Network* and Orofacial Pain Special Interest Groupdagger. J Oral Facial Pain Headache. 2014;28(1):6–27.

    Article  PubMed  PubMed Central  Google Scholar 

  98. Schmidt-Hansen PT, Svensson P, Bendtsen L, Graven-Nielsen T, Bach FW. Increased muscle pain sensitivity in patients with tension-type headache. Pain. 2007;129(1–2):113–21.

    Article  PubMed  Google Scholar 

  99. Sessle BJ. Peripheral and central mechanisms of orofacial inflammatory pain. Int Rev Neurobiol. 2011;97:179–206.

    Article  CAS  PubMed  Google Scholar 

  100. Shah JP, Danoff JV, Desai MJ, Parikh S, Nakamura LY, Phillips TM, Gerber LH. Biochemicals associated with pain and inflammation are elevated in sites near to and remote from active myofascial trigger points. Arch Phys Med Rehabil. 2008;89(1):16–23.

    Article  PubMed  Google Scholar 

  101. Slade GD, Conrad MS, Diatchenko L, Rashid NU, Zhong S, Smith S, Rhodes J, Medvedev A, Makarov S, Maixner W, Nackley AG. Cytokine biomarkers and chronic pain: association of genes, transcription, and circulating proteins with temporomandibular disorders and widespread palpation tenderness. Pain. 2011;152(12):2802–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  102. Slade GD, Sanders AE, Bair E, Brownstein N, Dampier D, Knott C, Fillingim R, Maixner WO, Smith S, Greenspan J, Dubner R, Ohrbach R. Preclinical episodes of orofacial pain symptoms and their association with health care behaviors in the OPPERA prospective cohort study. Pain. 2013;154(5):750–60.

    Article  PubMed  PubMed Central  Google Scholar 

  103. Slade GD, Sanders AE, Ohrbach R, Fillingim RB, Dubner R, Gracely RH, Bair E, Maixner W, Greenspan JD. Pressure pain thresholds fluctuate with, but do not usefully predict, the clinical course of painful temporomandibular disorder. Pain. 2014;155(10):2134–43.

    Article  PubMed  PubMed Central  Google Scholar 

  104. Smith SB, Mir E, Bair E, Slade GD, Dubner R, Fillingim RB, Greenspan JD, Ohrbach R, Knott C, Weir B, Maixner W, Diatchenko L. Genetic variants associated with development of TMD and its intermediate phenotypes: the genetic architecture of TMD in the OPPERA prospective cohort study. J Pain Offic J Am Pain Soc. 2013;14(12 Suppl):T91–101.e101–3.

    Article  Google Scholar 

  105. Staud R. Abnormal endogenous pain modulation is a shared characteristic of many chronic pain conditions. Expert Rev Neurother. 2012;12(5):577–85.

    Article  PubMed  PubMed Central  Google Scholar 

  106. Suzuki R, Rygh LJ, Dickenson AH. Bad news from the brain: descending 5-HT pathways that control spinal pain processing. Trends Pharmacol Sci. 2004;25(12):613–7.

    Article  CAS  PubMed  Google Scholar 

  107. Svensson P, Arendt-Nielsen L, Nielsen H, Larsen JK. Effect of chronic and experimental jaw muscle pain on pain-pressure thresholds and stimulus–response curves. J Orofac Pain. 1995;9(4):347–56.

    CAS  PubMed  Google Scholar 

  108. Svensson P, Cairns BE, Wang K, Arendt-Nielsen L. Injection of nerve growth factor into human masseter muscle evokes long-lasting mechanical allodynia and hyperalgesia. Pain. 2003;104(1–2):241–7.

    Article  CAS  PubMed  Google Scholar 

  109. Svensson P, Castrillon E, Cairns BE. Nerve growth factor-evoked masseter muscle sensitization and perturbation of jaw motor function in healthy women. J Orofac Pain. 2008;22(4):340–8.

    PubMed  Google Scholar 

  110. Svensson P, List T, Hector G. Analysis of stimulus-evoked pain in patients with myofascial temporomandibular pain disorders. Pain. 2001;92(3):399–409.

    Article  CAS  PubMed  Google Scholar 

  111. Takahashi T, Kondoh T, Fukuda M, Yamazaki Y, Toyosaki T, Suzuki R. Proinflammatory cytokines detectable in synovial fluids from patients with temporomandibular disorders. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(2):135–41.

    Article  CAS  PubMed  Google Scholar 

  112. Takeuchi Y, Zeredo JL, Fujiyama R, Amagasa T, Toda K. Effects of experimentally induced inflammation on temporomandibular joint nociceptors in rats. Neurosci Lett. 2004;354(2):172–4.

    Article  CAS  PubMed  Google Scholar 

  113. Tchivileva IE, Lim PF, Smith SB, Slade GD, Diatchenko L, McLean SA, Maixner W. Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study. Pharmacogenet Genomics. 2010;20(4):239–48.

    CAS  PubMed  PubMed Central  Google Scholar 

  114. Thomsen LL, Kirchmann M, Bjornsson A, Stefansson H, Jensen RM, Fasquel AC, Petursson H, Stefansson M, Frigge ML, Kong A, Gulcher J, Stefansson K, Olesen J. The genetic spectrum of a population-based sample of familial hemiplegic migraine. Brain J Neurol. 2007;130(Pt 2):346–56.

    Article  CAS  Google Scholar 

  115. Turp JC, Kowalski CJ, O’Leary N, Stohler CS. Pain maps from facial pain patients indicate a broad pain geography. J Dent Res. 1998;77(6):1465–72.

    Article  CAS  PubMed  Google Scholar 

  116. Vierck CJ, Wong F, King CD, Mauderli AP, Schmidt S, Riley 3rd JL. Characteristics of sensitization associated with chronic pain conditions. Clin J Pain. 2014;30(2):119–28.

    PubMed  PubMed Central  Google Scholar 

  117. Vij B, Whipple MO, Tepper SJ, Mohabbat AB, Stillman M, Vincent A. Frequency of migraine headaches in patients with fibromyalgia. Headache. 2015;55(6):860–5.

    Article  PubMed  Google Scholar 

  118. Villa G, Ceruti S, Zanardelli M, Magni G, Jasmin L, Ohara PT, Abbracchio MP. Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus. Mol Pain. 2010;6:89.

    Article  PubMed  PubMed Central  Google Scholar 

  119. Wang K, Arendt-Nielsen L, Jensen T, Svensson P. Reduction of clinical temporomandibular joint pain is associated with a reduction of the jaw-stretch reflex. J Orofac Pain. 2004;18(1):33–40.

    PubMed  Google Scholar 

  120. Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011;152(3 Suppl):S2–15.

    Article  PubMed  Google Scholar 

  121. Wright EF, Clark EG, Paunovich ED, Hart RG. Headache improvement through TMD stabilization appliance and self-management therapies. Cranio J Craniomandib Pract. 2006;24(2):104–11.

    Google Scholar 

  122. Xanthos DN, Sandkuhler J. Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity. Nat Rev Neurosci. 2014;15(1):43–53.

    Article  CAS  PubMed  Google Scholar 

  123. Yarnitsky D. Role of endogenous pain modulation in chronic pain mechanisms and treatment. Pain. 2015;156 Suppl 1:S24–31.

    Article  PubMed  Google Scholar 

  124. Yarnitsky D, Arendt-Nielsen L, Bouhassira D, Edwards RR, Fillingim RB, Granot M, Hansson P, Lautenbacher S, Marchand S, Wilder-Smith O. Recommendations on terminology and practice of psychophysical DNIC testing. Eur J Pain. 2010;14(4):339.

    Article  PubMed  Google Scholar 

  125. You HJ, Lei J, Sui MY, Huang L, Tan YX, Tjolsen A, Arendt-Nielsen L. Endogenous descending modulation: spatiotemporal effect of dynamic imbalance between descending facilitation and inhibition of nociception. J Physiol. 2010;588(Pt 21):4177–88.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  126. Yunus MB. Central sensitivity syndromes: a new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness. Semin Arthritis Rheum. 2008;37(6):339–52.

    Article  PubMed  Google Scholar 

  127. Zhao YJ, Liu Y, Zhao YH, Li Q, Zhang M, Chen YJ. Activation of satellite glial cells in the trigeminal ganglion contributes to masseter mechanical allodynia induced by restraint stress in rats. Neurosci Lett. 2015;602:150–5.

    Article  CAS  PubMed  Google Scholar 

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Exposto, F., Svensson, P., Arendt-Nielsen, L. (2017). Temporomandibular Disorder Comorbidity. In: Giamberardino, M., Martelletti, P. (eds) Comorbidities in Headache Disorders. Headache. Springer, Cham. https://doi.org/10.1007/978-3-319-41454-6_9

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