Shape-Controlled Nanoparticles for Drug Delivery and Targeting Applications
Whatever nanoparticles are envisioned for, including vaccinal, imaging, diagnostic, or drug targeting applications, their considerable interest originates from a unique combination of a nanometric size and the possibility to considerably modulate their physicochemical properties, including their geometry. There are nowadays growing experimental evidences that the morphology and the shape of nanoparticles can significantly contribute to their pharmacokinetics in the body, by influencing various physicochemical mechanisms such as their diffusivity, interactions with biological materials, internalization by cells. We present here a review of the present knowledge in this field. After a brief discussion on the different phenomena on which shape can have an influence, the different preparation methods currently available to obtain nonspherical nanoparticles will be presented. Their pro and cons will be discussed, regarding surface properties control, scale-up potential, etc.
KeywordsNanoparticles Drug delivery Drug targeting Shape Morphology Self-assembling Amphipilic copolymers Peptides Manufacturing methods
- Lleo MM, Canepari P, Satta G (1990) Bacterial cell shape regulation: testing of additional predictions unique to the two-competing-sites model for peptidoglycan assembly and isolation of conditional rod-shaped mutants from some wild-type cocci. J Bacteriol 172:3758–3771CrossRefPubMedPubMedCentralGoogle Scholar
- Parakhonskiy B, Zyuzin M, Uashchenok A, Carregal-Romero S, Rejman J, Möhwald H, Parak WJ, Skirtach AG (2015) The influence of the size and aspect ratio of anisotropic, porous CaCO3 particles on their uptake by cells. J Nanobiotechnol 13(53):1–13Google Scholar
- Perry JL, Reuter KG, Kai MP, Herlihy KP, Jones SW, Luft JC, Napier M, Bear JE, DeSimone JM (2012) PEgylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics. Nano Lett 12:5304–5310CrossRefPubMedPubMedCentralGoogle Scholar
- Scanlon S, Aggeli A (2008) Self-assemblying peptide nanotubes. Nanotoday 3(3–4):22–30Google Scholar