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Shape-Controlled Nanoparticles for Drug Delivery and Targeting Applications

  • Gilles PonchelEmail author
  • Olivier Cauchois
Chapter

Abstract

Whatever nanoparticles are envisioned for, including vaccinal, imaging, diagnostic, or drug targeting applications, their considerable interest originates from a unique combination of a nanometric size and the possibility to considerably modulate their physicochemical properties, including their geometry. There are nowadays growing experimental evidences that the morphology and the shape of nanoparticles can significantly contribute to their pharmacokinetics in the body, by influencing various physicochemical mechanisms such as their diffusivity, interactions with biological materials, internalization by cells. We present here a review of the present knowledge in this field. After a brief discussion on the different phenomena on which shape can have an influence, the different preparation methods currently available to obtain nonspherical nanoparticles will be presented. Their pro and cons will be discussed, regarding surface properties control, scale-up potential, etc.

Keywords

Nanoparticles Drug delivery Drug targeting Shape Morphology Self-assembling Amphipilic copolymers Peptides Manufacturing methods 

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Institut Galien Paris Sud, Faculty of PharmacyCNRS, Univ. of Paris-Sud, University Paris SaclayChâtenay-MalabryFrance

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