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Interaction Between Nanoparticles and Plasma Proteins: Effects on Nanoparticle Biodistribution and Toxicity

  • Anna N. Ilinskaya
  • Marina A. DobrovolskaiaEmail author
Chapter

Abstract

Nanoparticles are increasingly used in biomedical applications as active pharmaceutical ingredients, drug carriers, or medical devices. Nanoparticles interaction with plasma proteins may influence their biodistribution by promoting interaction with and uptake by the circulating and tissue resident phagocytes. Biodistribution to off intended target-sites may lead to decrease in therapeutic efficacy and result in undesirable toxicities. Therefore understanding nanoparticle physicochemical properties, which determine protein binding, and consequences of protein corona on nanoparticle biodistribution and toxicity are important elements of the preclinical development of nanomedicines and nanoparticle-based medical devices. The focus of this chapter is to discuss the most recent data on nanoparticle interactions with blood components and how particle size and surface charge define their compatibility with the immune system.

Keywords

Bovine serum albumin (BSA) Complement activation related pseudoallergy (CARPA) Complement receptor (CR) High density lipoprotein (HDL) Mononuclear phagocytic system (MPS) Mass spectrometry (MS) N-Acetyltransferase 1 (NAC1) Polyacrylamide gel electrophoresis (PAGE) Pharmacodynamic (PD) Poly(ethylene glycol) (PEG) Pharmacokinetic (PK) Reactive oxygen species (ROS) Thermo-responsive diblock copolymer nanoparticles (TDCN) 

Notes

Acknowledgments

This project has been funded in whole or in part with Federal funds from the Frederick National Laboratory for Cancer Research, National Institutes of Health, under contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government.

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© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Frederick National Laboratory for Cancer ResearchLeidos Biomedical Research Inc.FrederickUSA

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