Interaction Between Nanoparticles and Plasma Proteins: Effects on Nanoparticle Biodistribution and Toxicity
Nanoparticles are increasingly used in biomedical applications as active pharmaceutical ingredients, drug carriers, or medical devices. Nanoparticles interaction with plasma proteins may influence their biodistribution by promoting interaction with and uptake by the circulating and tissue resident phagocytes. Biodistribution to off intended target-sites may lead to decrease in therapeutic efficacy and result in undesirable toxicities. Therefore understanding nanoparticle physicochemical properties, which determine protein binding, and consequences of protein corona on nanoparticle biodistribution and toxicity are important elements of the preclinical development of nanomedicines and nanoparticle-based medical devices. The focus of this chapter is to discuss the most recent data on nanoparticle interactions with blood components and how particle size and surface charge define their compatibility with the immune system.
KeywordsBovine serum albumin (BSA) Complement activation related pseudoallergy (CARPA) Complement receptor (CR) High density lipoprotein (HDL) Mononuclear phagocytic system (MPS) Mass spectrometry (MS) N-Acetyltransferase 1 (NAC1) Polyacrylamide gel electrophoresis (PAGE) Pharmacodynamic (PD) Poly(ethylene glycol) (PEG) Pharmacokinetic (PK) Reactive oxygen species (ROS) Thermo-responsive diblock copolymer nanoparticles (TDCN)
This project has been funded in whole or in part with Federal funds from the Frederick National Laboratory for Cancer Research, National Institutes of Health, under contract HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products or organizations imply endorsement by the US Government.
- Brown DM, Donaldson K, Borm PJ, Schins RP, Dehnhardt M, Gilmour P et al (2004) Calcium and ROS-mediated activation of transcription factors and TNF-alpha cytokine gene expression in macrophages exposed to ultrafine particles. Am J Physiol Lung Cell Mol Physiol 286(2):L344–L353PubMedCrossRefGoogle Scholar
- Capriotti AL, Cavaliere C, Foglia P, Samperi R, Stampachiacchiere S, Ventura S et al (2014) Multiclass analysis of mycotoxins in biscuits by high performance liquid chromatography-tandem mass spectrometry. Comparison of different extraction procedures. J Chromatogr A 1343:69–78PubMedCrossRefGoogle Scholar
- Caron WP, Rawal S, Song G, Kumar P, Lay JC, Zamboni WC (2013b) Bidirectional interaction between nanoparticles and cells of the mononuclear phagocytic system. In: Dobrovolskaia MA, McNeil SE (eds) Handbook of immunological properties of engoineered nanomaterilas. World Scientific Publishing Co. Pte. Ltd., Singapore, pp 385–416CrossRefGoogle Scholar
- Fleischer CC, Payne CK (2014) Secondary structure of corona proteins determines the cell surface receptors used by nanoparticles. J Phys Chem BGoogle Scholar
- Mohr K, Sommer M, Baier G, Schottler S, Okwieka P, Tenzer S, Landfester K, Mailander V, Schmidt M, Meyer RG (2014) Aggregation behavior of polysterene-nanoparticles in human blood serum and its impact on the in vivo distribution in mice. J Nanomed Nanotechnol 5(2)Google Scholar
- Treuel L, Nienhaus UG (2013) Nanoparticles interaction with plasma proteins and its relates to biodistribution. In: Dobrovolskaia MA, McNeil SE (eds) Handbook of immunological properties of engineered nanomaterials. World Scientific Publishing Co. Pte. Ltd., Singapore, pp 151–172CrossRefGoogle Scholar
- Yazdi AS, Guarda G, Riteau N, Drexler SK, Tardivel A, Couillin I et al (2010) Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1alpha and IL-1beta. Proc Natl Acad Sci USA 107(45):19449–19454PubMedPubMedCentralCrossRefGoogle Scholar
- Zaman M, Ahmad E, Qadeer A, Rabbani G, Khan RH (2014) Nanoparticles in relation to peptide and protein aggregation. Int J Nanomed 9:899–912Google Scholar