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Drug Delivery by Polymer Nanoparticles: The Challenge of Controlled Release and Evaluation

  • Christine CharrueauEmail author
  • Christelle Zandanel

Abstract

The controlled release of the drugs at the site of action is a key issue for nanoparticulate carriers. The purpose of this chapter is to review the current strategies used to control the release profiles of polymer nanoparticles. Based on 12 representative drugs with hydrophobic or hydrophilic properties, the mechanisms controlling the drug release are described, the different ways to tune the release profile are analyzed, and the methods for evaluating drug release from nanoparticles are discussed. In conclusion, based on the physicochemical properties of the drugs, the types and characteristics of nanoformulations, and the route of administration, promising tracks for tuning release profiles can be proposed. Suggestions for choosing the most appropriate methods for studying drug release are also presented.

Keywords

Drug release Nanoparticles Hydrophobic drugs Hydrophilic drugs Dissolution Dialysis Diffusion Pharmacokinetics Release evaluation 

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Faculté de Pharmacie de l’Université Paris Descartes, Unité de Technologies Chimiques et Biologiques pour la Santé UTCBSCNRS UMR8258 – Inserm U1022Paris Cedex 06France
  2. 2.Institut Galien Paris Sud, UMR CNRS 8612, Univ. Paris Sud, Université Paris-SaclayChâtenay-MalabryFrance

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