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Designing Polymer Nanoparticle Nanomedicines: Potential Applications and Challenges

  • Christine VauthierEmail author
Chapter

Abstract

Several challenges need to be fulfilled to design polymer nanoparticles with suitable characteristics to achieve desired applications as nanomedicine. The part 3 of the book was aimed to discuss different approaches that are used to tune characteristics of nanoparticles adjusting functionalities needed to maximize the efficacy of the delivery approach. A chapter is devoted to the synthesis of polymers that are main components of the polymer nanoparticles and give several functionalities to the final nanoparticles. The different ways to achieve association of drugs and approaches that can be developed to control the release of the drug from the nanoparticles are presented in two distinct chapters. Other aspects included in this part of the book are devoted to the understanding of interactions between proteins and nanoparticles that are at the bottom of the control of the biodistribution and safety of nanoparticles. A final chapter proposes a prospective view on developments of polymer nanoparticles as tools for theranostic combining therapeutic and diagnostic functionalities. This introduction to the part 3 of the book is aimed to place these chapters in the more global prospective of designing functional nanomedicines based on polymer nanoparticles in regard with their potential applications and challenges to complete.

Keywords

Polymer Colloid Chemotherapy Clinical trials Biocompatible Biodegradable Biodistribution Diagnostic Drug-ability Drug delivery Imaging Intracellular delivery Intravenous injection Mucosal administration Nucleic acids siRNA Peptides Personalized medicine Polymer Proteins Systemic activity Target cells Target tissue Theranostic Therapeutic activity Treatment 

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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  1. 1.Institut Galien Paris Sud, Faculty of PharmacyUMR CNRS 8612, University of Paris-Sud, University Paris SaclayChâtenay-Malabry CedexFrance

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