Spinal Cord and Peripheral Nerve Regeneration Current Research and Future Possibilities

  • Wise YoungEmail author
  • Hilton M. Kaplan


Our nervous system is remarkably elegant but also exceedingly complex. These complexities create monumental hurdles to regeneration. The current state of the art in spinal cord and peripheral nerve regeneration are explored. Future possibilities are laid out – aiming ultimately not just to restore function but almost certainly to even enhance it.


Spinal cord Peripheral nerve Nervous system Regeneration Future possibilities 



Oncogene of transforming retrovirus AKT8 (also Akt1 and PKB)


Activating transcription factor 2


Activating transcription factor 3


Brain-to-brain interface


Brain-derived neurotrophic factor


Chondroitinase ABC


Cyclic adenosine monophosphate


Contactin-associated protein


Conformité Européenne


Central nervous system


Chondroitin-6-sulfate proteoglycan


Designer Receptors Exclusively Activated by Designer Drugs


Dorsal root ganglia




Food and Drug Administration


Floating light-activated microelectrical stimulators


Glial fibrillary acidic protein


Glial hyaluronate-binding protein


Heparin sulfate proteoglycan


Insulin-like growth factor-1




IgM antibody that inhibits axonal growth


Keratin sulfate proteoglycan (KSPG)


Myelin-associated glycoprotein


Mammalian target of rapamycin


Neural Enhancement Divide


Peptide 1–40 of Nogo that inhibits NgR


Neural/glial antigen 2 (includes CSPG4)


Nerve guidance conduit


Nogo receptor


Nogo receptor 1


Nogo receptor 3


Neuromuscular electrical stimulation


Neuronal growth inhibitory molecule in myelin


The A version of Nogo


Nogo-A and Nogo-B genes


Nervous System 2.0


Neurotrophin receptor (p75 receptor)


Oligodendroglial myelin glycoprotein


75 KD protein


Pheochromocytoma 12


Platelet-derived growth factor


Phosphoinositide-dependent protein kinase 1 and 2


Phosphoinositol 3 kinase


Phosphoinositol phosphate 2


Phosphoinositol phosphate 3


Phosphokinase A


Phosphokinase B (also Akt) a serine/threonine protein kinase


Peripheral nervous system


Phosphatase tensin homologue


Ras homologue enriched in brain 1


Rho A


Rho kinase


Receptor protein tyrosine phosphatase sigma


Spinal cord injury


Signal transducer and activator of transcription 3


Tuberous sclerosis 1 and 2


University of California San Diego


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Copyright information

© Springer International Publishing Switzerland 2017

Authors and Affiliations

  1. 1.Rutgers, The State University of New JerseyNew BrunswickUSA

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