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Mechanics of Biological Systems and Materials, Volume 6 pp 83–87Cite as

Rheology of Soft and Rigid Micro Particles in Curved Microfluidic Channels

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Part of the Conference Proceedings of the Society for Experimental Mechanics Series book series (CPSEMS)

Abstract

We investigated the rheological behavior of micro particles in inertial flow in a curved microfluidic channel. Different from the typical microfluidic regime operating at low Reynolds number, inertial flow provides hydrodynamic manipulation, namely inertial focusing of particles at high flow speeds. Primary influences of inertial flow on particle motions are several: repulsive force from the wall due to a pressure buildup in the constriction between the wall and the particle, shear gradient lift force due to the parabolic flow profile at microscale, and secondary drag force in the cross-sectional direction due to channel curvature. These forces result in particle moving across the streamlines to certain predictable equilibrium positions in the flow. With regard to soft particles, their flow behavior and equilibrium positions may deviate from the theoretical predictions based on rigid particles. This study provides a proof-of-concept of inertial focusing-based separation of particles with different deformability. We demonstrated its capability by separating yeast cells and polystyrene particles of similar sizes in a double spiral channel.

Keywords

  • Biological cell
  • Inertial focusing
  • Hydrodynamics
  • Deoxygenation
  • Particle separation

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Acknowledgement

This material is based upon work supported by the National Science Foundation under Grant No. 1464102.

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Authors and Affiliations

  1. Department of Ocean and Mechanical Engineering, Florida Atlantic University, Boca Raton, FL, 33431, USA

    Jia Liu, Yuhao Qiang, Michael Mian & E. Du

  2. National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY, 11973, USA

    Weihe Xu

Authors
  1. Jia Liu
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  2. Yuhao Qiang
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  3. Michael Mian
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  4. Weihe Xu
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  5. E. Du
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Corresponding author

Correspondence to E. Du .

Editor information

Editors and Affiliations

  1. Department of Mechanical Engineering, State University of New York at Stony Brook, Stony Brook, New York, USA

    Chad S. Korach

  2. Michigan State University , East Lansing, Michigan, USA

    Srinivasan Arjun Tekalur

  3. Purdue University, West Lafayette, Indiana, USA

    Pablo Zavattieri

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Liu, J., Qiang, Y., Mian, M., Xu, W., Du, E. (2017). Rheology of Soft and Rigid Micro Particles in Curved Microfluidic Channels. In: Korach, C., Tekalur, S., Zavattieri, P. (eds) Mechanics of Biological Systems and Materials, Volume 6. Conference Proceedings of the Society for Experimental Mechanics Series. Springer, Cham. https://doi.org/10.1007/978-3-319-41351-8_12

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  • DOI: https://doi.org/10.1007/978-3-319-41351-8_12

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  • Publisher Name: Springer, Cham

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