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Auraptene and Its Role in Chronic Diseases

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Drug Discovery from Mother Nature

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 929))

Abstract

Auraptene (7-geranyloxycoumarin) is the best known and most abundant prenyloxycoumarin present in nature. It is synthesized by various plant species, mainly those of the Rutaceae and Umbeliferae (Apiaceae) families, comprising many edible fruits and vegetables such as lemons, grapefruit and orange. Auraptene has shown a remarkable effect in the prevention of degenerative diseases, in particular it has been reported to be one the most promising known natural chemopreventive agents against several types of cancer. The aim of this chapter is to review the effects of auraptene in the prevention and treatment of different chronic diseases.

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Author information

Authors and Affiliations

  1. Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico San Matteo, P.le C. Golgi, 2-27100, Pavia, Italy

    Giuseppe Derosa & Pamela Maffioli

  2. Center for Prevention, Surveillance, Diagnosis and Treatment of Rare Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

    Giuseppe Derosa & Pamela Maffioli

  3. Center for the Study of Endocrine-Metabolic Pathophysiology and Clinical Research, University of Pavia, Pavia, Italy

    Giuseppe Derosa

  4. Laboratory of Molecular Medicine, University of Pavia, Pavia, Italy

    Giuseppe Derosa

  5. PhD School in Experimental Medicine, University of Pavia, Pavia, Italy

    Pamela Maffioli

  6. Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhossein Sahebkar

  7. School of Medicine and Pharmacology, Metabolic Research Centre, Royal Perth Hospital, University of Western Australia, Perth, Australia

    Amirhossein Sahebkar

  8. Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, P.O. Box: 91779-48564, Mashhad, Iran

    Amirhossein Sahebkar

Authors
  1. Giuseppe Derosa
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  2. Pamela Maffioli
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  3. Amirhossein Sahebkar
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Corresponding authors

Correspondence to Giuseppe Derosa or Amirhossein Sahebkar .

Editor information

Editors and Affiliations

  1. Banaras Hindu University, Varanasi, Uttar Pradesh, India

    Subash Chandra Gupta

  2. MD Anderson Cancer Center, University of Texas, Houston, Texas, USA

    Sahdeo Prasad

  3. Inflammation Research Institute, San Diego, California, USA

    Bharat B. Aggarwal

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Derosa, G., Maffioli, P., Sahebkar, A. (2016). Auraptene and Its Role in Chronic Diseases. In: Gupta, S., Prasad, S., Aggarwal, B. (eds) Drug Discovery from Mother Nature. Advances in Experimental Medicine and Biology, vol 929. Springer, Cham. https://doi.org/10.1007/978-3-319-41342-6_19

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