Skip to main content

Cinnamon and Chronic Diseases

  • Chapter
  • First Online:
Drug Discovery from Mother Nature

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 929))

Abstract

Cinnamon (Cinnamomum zeylanicum and Cinnamon cassia), the eternal tree of tropical medicine, belongs to the Lauraceae family and is one of the most important spices used daily by people all over the world. It contains a lot of manganese, iron, dietary fiber, and calcium. Cinnamon contains derivatives, such as cinnamaldehyde, cinnamic acid, cinnamate, and numerous other components such as polyphenols and antioxidant, anti-inflammatory, antidiabetic, antimicrobial, anticancer effects. Several reports have dealt with the numerous properties of cinnamon in the forms of bark, essential oils, bark powder, and phenolic compounds, and each of these properties can play a key role in human health. Recently, many trials have explored the beneficial effects of cinnamon in Alzheimer’s disease, diabetes, arthritis, and arteriosclerosis, but still we need further investigations to provide additional clinical evidence for this spice against cancer and inflammatory, cardioprotective, and neurological disorders.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Tulunay M, Aypak C, Yikilkan H, Gorpelioglu S (2015) Herbal medicine use among patients with chronic diseases. J Intercult Ethnopharmacol 4(3):217–220. PubMed PMID: 26401410. Pubmed Central PMCID: PMC4579486. Epub 2015/09/25. eng

    Google Scholar 

  2. Chan KW, Khong NM, Iqbal S, Ch’ng SE, Younas U, Babji AS (2014) Cinnamon bark deodorised aqueous extract as potential natural antioxidant in meat emulsion system: a comparative study with synthetic and natural food antioxidants. J Food Sci Technol 51(11):3269–3276. PubMed PMID: 26396320. Pubmed Central PMCID: PMC4571215. Epub 2015/09/24. eng

    Google Scholar 

  3. Shalaby MA, Saifan HY (2014) Some pharmacological effects of cinnamon and ginger herbs in obese diabetic rats. J Intercult Ethnopharmacol 3(4):144–149. PubMed PMID: 26401364. Pubmed Central PMCID: PMC4576807. Epub 2015/09/25. eng

    Google Scholar 

  4. Shan B, Cai YZ, Brooks JD, Corke H (2007) Antibacterial properties and major bioactive components of cinnamon stick (Cinnamomum burmannii): activity against foodborne pathogenic bacteria. J Agric Food Chem 55(14):5484–5490. PubMed PMID: 17567030. Epub 2007/06/15. eng

    Google Scholar 

  5. Shahwar D, Ullah S, Khan MA, Ahmad N, Saeed A, Ullah S (2015) Anticancer activity of Cinnamon tamala leaf constituents towards human ovarian cancer cells. Pak J Pharm Sci. 28(3):969–972. PubMed PMID: 26004731. Epub 2015/05/26. eng

    Google Scholar 

  6. Javed I, Faisal I, Rahman Z, Khan MZ, Muhammad F, Aslam B et al (2012) Lipid lowering effect of Cinnamomum zeylanicum in hyperlipidaemic albino rabbits. Pak J Pharm Sci 25(1):141–147. PubMed PMID: 22186322. Epub 2011/12/22. eng

    Google Scholar 

  7. Jin S, Cho KH (2011) Water extracts of cinnamon and clove exhibits potent inhibition of protein glycation and anti-atherosclerotic activity in vitro and in vivo hypolipidemic activity in zebrafish. Food Chem Toxicol Int J Published Br Ind Biol Res Assoc 49(7):1521–1529. PubMed PMID: 21443916. Epub 2011/03/30. eng

    Google Scholar 

  8. Medagama AB, Bandara R (2014) The use of complementary and alternative medicines (CAMs) in the treatment of diabetes mellitus: is continued use safe and effective? Nutr J 13:102. PubMed PMID: 25331834. Pubmed Central PMCID: PMC4210501. Epub 2014/10/22. eng

    Google Scholar 

  9. Chen J, Jiang QD, Wu YM, Liu P, Yao JH, Lu Q et al (2015) Potential of essential oils as penetration enhancers for transdermal administration of ibuprofen to treat dysmenorrhoea. Molecules 20(10):18219–18236. PubMed PMID: 26457698. Epub 2015/10/13. eng

    Google Scholar 

  10. Anderson RA, Qin B, Canini F, Poulet L, Roussel AM (2013) Cinnamon counteracts the negative effects of a high fat/high fructose diet on behavior, brain insulin signaling and Alzheimer-associated changes. PLoS One 8(12):e83243. PubMed PMID: 24349472. Pubmed Central PMCID: PMC3862724. Epub 2013/12/19. eng

    Google Scholar 

  11. Kawatra P, Rajagopalan R (2015) Cinnamon: mystic powers of a minute ingredient. Pharmacognosy Res 7(Suppl 1):S1–S6. PubMed PMID: 26109781. Pubmed Central PMCID: PMC4466762. Epub 2015/06/26. eng

    Google Scholar 

  12. Jayaprakasha GK, Rao LJ (2011) Chemistry, biogenesis, and biological activities of Cinnamomum zeylanicum. Crit Rev Food Sci Nutr 51(6):547–562. PubMed PMID: 21929331. Epub 2011/09/21. eng

    Google Scholar 

  13. Rao PV, Gan SH (2014) Cinnamon: a multifaceted medicinal plant. Evid Based Complement Altern Med eCAM 2014:642942. PubMed PMID: 24817901. Pubmed Central PMCID: PMC4003790. Epub 2014/05/13. eng

    Google Scholar 

  14. Singh G, Maurya S, DeLampasona MP, Catalan CA (2007) A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents. Food Chem Toxicol Int J Published Br Ind Biol Res Assoc 45(9):1650–1661. PubMed PMID: 17408833. Epub 2007/04/06. eng

    Google Scholar 

  15. Schoene NW, Kelly MA, Polansky MM, Anderson RA (2009) A polyphenol mixture from cinnamon targets p38 MAP kinase-regulated signaling pathways to produce G2/M arrest. J Nutr Biochem 20(8):614–620. PubMed PMID: 18835704. Epub 2008/10/07. eng

    Google Scholar 

  16. Cao H, Graves DJ, Anderson RA (2010) Cinnamon extract regulates glucose transporter and insulin-signaling gene expression in mouse adipocytes. Phytomedicine Int J Phytotherapy Phytopharmacol 17(13):1027–1032. PubMed PMID: 20554184. Epub 2010/06/18. eng

    Google Scholar 

  17. Jitomir J, Willoughby DS (2009) Cassia cinnamon for the attenuation of glucose intolerance and insulin resistance resulting from sleep loss. J Med Food 12(3):467–472. PubMed PMID: 19627193. Epub 2009/07/25. eng

    Google Scholar 

  18. Chericoni S, Prieto JM, Iacopini P, Cioni P, Morelli I (2005) In vitro activity of the essential oil of Cinnamomum zeylanicum and eugenol in peroxynitrite-induced oxidative processes. J Agric Food Chem 53(12):4762–4765. PubMed PMID: 15941312. Epub 2005/06/09. eng

    Google Scholar 

  19. Lee SH, Lee SY, Son DJ, Lee H, Yoo HS, Song S et al (2005) Inhibitory effect of 2′-hydroxycinnamaldehyde on nitric oxide production through inhibition of NF-kappa B activation in RAW 264.7 cells. Biochem Pharmacol 69(5):791–799. PubMed PMID: 15710356. Epub 2005/02/16. eng

    Google Scholar 

  20. Yu T, Lee S, Yang WS, Jang HJ, Lee YJ, Kim TW et al (2012) The ability of an ethanol extract of Cinnamomum cassia to inhibit Src and spleen tyrosine kinase activity contributes to its anti-inflammatory action. J Ethnopharmacol 139(2):566–573. PubMed PMID: 22155395. Epub 2011/12/14. eng

    Google Scholar 

  21. Youn HS, Lee JK, Choi YJ, Saitoh SI, Miyake K, Hwang DH et al (2008) Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. Biochem Pharmacol 75(2):494–502. PubMed PMID: 17920563. Epub 2007/10/09. eng

    Google Scholar 

  22. Yu SM, Ko FN, Wu TS, Lee JY, Teng CM (1994) Cinnamophilin, a novel thromboxane A2 receptor antagonist, isolated from Cinnamomum philippinense. Eur J Pharmacol 256(1):85–91. PubMed PMID: 8026563. Epub 1994/04/11. eng

    Google Scholar 

  23. Lee EJ, Chen HY, Hung YC, Chen TY, Lee MY, Yu SC et al (2009) Therapeutic window for cinnamophilin following oxygen-glucose deprivation and transient focal cerebral ischemia. Exp Neurol 217(1):74–83. PubMed PMID: 19416670. Epub 2009/05/07. eng

    Google Scholar 

  24. Panickar KS, Polansky MM, Graves DJ, Urban JF Jr, Anderson RA (2012) A procyanidin type A trimer from cinnamon extract attenuates glial cell swelling and the reduction in glutamate uptake following ischemia-like injury in vitro. Neuroscience 202:87–98. PubMed PMID: 22166344. Epub 2011/12/15. eng

    Google Scholar 

  25. Dagli N, Dagli R, Mahmoud RS, Baroudi K (2015) Essential oils, their therapeutic properties, and implication in dentistry: a review. J Int Soc Prev Commun Dent 5(5):335–340. PubMed PMID: 26539382. Pubmed Central PMCID: PMC4606594. Epub 2015/11/06. eng

    Google Scholar 

  26. Im K, Issac A, Nm J, Ninan E, Maliakel B, Kuttan R (2014) Effects of the polyphenol content on the anti-diabetic activity of Cinnamomum zeylanicum extracts. Food Funct 5(9):2208–2220. PubMed PMID: 25051315. Epub 2014/07/23. eng

    Google Scholar 

  27. Allen RW, Schwartzman E, Baker WL, Coleman CI, Phung OJ (2013) Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis. Ann Fam Med 11(5):452–459. PubMed PMID: 24019277. Pubmed Central PMCID: PMC3767714. Epub 2013/09/11. eng

    Google Scholar 

  28. Bernardo MA, Silva ML, Santos E, Moncada MM, Brito J, Proenca L et al (2015) Effect of cinnamon tea on postprandial glucose concentration. J Diabetes Res 2015:913651. PubMed PMID: 26258147. Pubmed Central PMCID: PMC4516848. Epub 2015/08/11. eng

    Google Scholar 

  29. Akilen R, Tsiami A, Devendra D, Robinson N (2010) Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial. Diabet Med J Br Diabet Assoc 27(10):1159–67. PubMed PMID: 20854384. Epub 2010/09/22. eng

    Google Scholar 

  30. Li R, Liang T, Xu L, Li Y, Zhang S, Duan X (2013) Protective effect of cinnamon polyphenols against STZ-diabetic mice fed high-sugar, high-fat diet and its underlying mechanism. Food Chem Toxicol Int J Published Br Ind Biol Res Assoc 51:419–425. PubMed PMID: 23127600. Epub 2012/11/07. eng

    Google Scholar 

  31. Solomon TP, Blannin AK (2007) Effects of short-term cinnamon ingestion on in vivo glucose tolerance. Diabetes Obes Metab 9(6):895–901. PubMed PMID: 17924872. Epub 2007/10/11. eng

    Google Scholar 

  32. Hlebowicz J, Darwiche G, Bjorgell O, Almer LO (2007) Effect of cinnamon on postprandial blood glucose, gastric emptying, and satiety in healthy subjects. Am J Clin Nutr 85(6):1552–1556. PubMed PMID: 17556692. Epub 2007/06/09. eng

    Google Scholar 

  33. Mettler S, Schwarz I, Colombani PC (2009) Additive postprandial blood glucose-attenuating and satiety-enhancing effect of cinnamon and acetic acid. Nutr Res 29(10):723–727. PubMed PMID: 19917452. Epub 2009/11/18. eng

    Google Scholar 

  34. Hlebowicz J, Hlebowicz A, Lindstedt S, Bjorgell O, Hoglund P, Holst JJ et al (2009) Effects of 1 and 3 g cinnamon on gastric emptying, satiety, and postprandial blood glucose, insulin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and ghrelin concentrations in healthy subjects. Am J Clin Nutr 89(3):815–821. PubMed PMID: 19158209. Epub 2009/01/23. eng

    Google Scholar 

  35. Deane AM, Nguyen NQ, Stevens JE, Fraser RJ, Holloway RH, Besanko LK et al (2010) Endogenous glucagon-like peptide-1 slows gastric emptying in healthy subjects, attenuating postprandial glycemia. J Clin Endocrinol Metab 95(1):215–221. PubMed PMID: 19892837. Epub 2009/11/07. eng

    Google Scholar 

  36. Naslund E, Bogefors J, Skogar S, Gryback P, Jacobsson H, Holst JJ et al (1999) GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans. Am J Physiol 277(3 Pt 2):R910–R916. PubMed PMID: 10484511. Epub 1999/09/14. eng

    Google Scholar 

  37. Palma A, Ruiz Montoya M, Arteaga JF, Rodriguez Mellado JM (2014) Determination of antioxidant activity of spices and their active principles by differential pulse voltammetry. J Agric Food Chem 62(3):582–589. PubMed PMID: 25264569. Epub 2014/09/30. eng

    Google Scholar 

  38. Boque N, Campion J, de la Iglesia R, de la Garza AL, Milagro FI, San Roman B et al (2013) Screening of polyphenolic plant extracts for anti-obesity properties in Wistar rats. J Sci Food Agric 93(5):1226–1232. PubMed PMID: 23080265. Epub 2012/10/20. eng

    Google Scholar 

  39. Luo Q, Wang SM, Lu Q, Luo J, Cheng YX (2013) Identification of compounds from the water soluble extract of Cinnamomum cassia barks and their inhibitory effects against high-glucose-induced mesangial cells. Molecules 18(9):10930–10943. PubMed PMID: 24013407. Epub 2013/09/10. eng

    Google Scholar 

  40. Muthenna P, Raghu G, Kumar PA, Surekha MV, Reddy GB (2014) Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats. Chem Biol Interact 222C:68–76. PubMed PMID: 25199697. Epub 2014/09/10. Eng

    Google Scholar 

  41. Akilen R, Pimlott Z, Tsiami A, Robinson N (2013) Effect of short-term administration of cinnamon on blood pressure in patients with prediabetes and type 2 diabetes. Nutrition 29(10):1192–1196. PubMed PMID: 23867208. Epub 2013/07/23. eng

    Google Scholar 

  42. Bano F, Ikram H, Akhtar N (2014) Neurochemical and behavioral effects of Cinnamomi cassiae (Lauraceae) bark aqueous extract in obese rats. Pak J Pharm Sci 27(3):559–563. PubMed PMID: 24811817. Epub 2014/05/09. eng

    Google Scholar 

  43. Lee SC, Xu WX, Lin LY, Yang JJ, Liu CT (2013) Chemical composition and hypoglycemic and pancreas-protective effect of leaf essential oil from indigenous cinnamon (Cinnamomum osmophloeum Kanehira). J Agric Food Chem 22;61(20):4905–4913. PubMed PMID: 23627599. Epub 2013/05/01. eng

    Google Scholar 

  44. Aletaha D (2015) Management of rheumatoid arthritis: what happens and what does not happen in real life. Rheumatol Int. PubMed PMID: 26687684. Epub 2015/12/22. eng

    Google Scholar 

  45. Catrina AI, Joshua V, Klareskog L, Malmstrom V (2016) Mechanisms involved in triggering rheumatoid arthritis. Immunol Rev 269(1):162–174. PubMed PMID: 26683152. Epub 2015/12/20. eng

    Google Scholar 

  46. Arthritis AFWir (2015) www.arthritis.org/about-arthritis/types/rheumatoid-arthritis/what-is-rheumatoid-arthritis.php

  47. Kirtikar KR, Basu BEB (1975) Indian medicinal plants. In: Dun D (ed) Bishen Singh Mahendra Pal Singh

    Google Scholar 

  48. Kubo M, Ma S, Wu J, Matsuda H (1996) Anti-inflammatory activities of 70 % methanolic extract from Cinnamomi Cortex. Biol Pharm Bull 19(8):1041–1045. PubMed PMID: 8874812. Epub 1996/08/01. eng

    Google Scholar 

  49. Mitra SK, Sundaram R, Venkataranganna MV, Gopumadhavan S, Prakash NS, Jayaram HD et al (2000) Anti-inflammatory, antioxidant and antimicrobial activity of Ophthacare brand, an herbal eye drops. Phytomed Int J Phytotherapy Phytopharmacol 7(2):123–127. PubMed PMID: 10839215. Epub 2000/06/06. eng

    Google Scholar 

  50. Atta AH, Alkofahi A (1998) Anti-nociceptive and anti-inflammatory effects of some Jordanian medicinal plant extracts. J Ethnopharmacol 60(2):117–124. PubMed PMID: 9582001. Epub 1998/05/15. eng

    Google Scholar 

  51. Ravindran PN, Nirmal-Babu K, Shylaja M (2003) Cinnamon and cassia: the genus Cinnamomum. CRS Press

    Google Scholar 

  52. Chang H-M, But P-H (1886) Pharmacology and applications of Chinese materia medica. Singapore: World Scientific

    Google Scholar 

  53. Lee BJ, Kim YJ, Cho DH, Sohn NW, Kang H (2011) Immunomodulatory effect of water extract of cinnamon on anti-CD3-induced cytokine responses and p38, JNK, ERK1/2, and STAT4 activation. Immunopharmacol Immunotoxicol 33(4):714–722. PubMed PMID: 22053946. Epub 2011/11/08. eng

    Google Scholar 

  54. Cao H, Urban JF Jr, Anderson RA (2008) Cinnamon polyphenol extract affects immune responses by regulating anti- and proinflammatory and glucose transporter gene expression in mouse macrophages. J Nutr 138(5):833–840. PubMed PMID: 18424588. Epub 2008/04/22. eng

    Google Scholar 

  55. Garella S, Matarese RA (1984) Renal effects of prostaglandins and clinical adverse effects of nonsteroidal anti-inflammatory agents. Medicine (Baltimore) 63(3):165–181. PubMed PMID: 6371441. Epub 1984/05/01. eng

    Google Scholar 

  56. Kang H, Park SH, Yun JM, Nam TG, Kim YE, Kim DO et al (2014) Effect of cinnamon water extract on monocyte-to-macrophage differentiation and scavenger receptor activity. BMC Complement Altern Med 14:90. PubMed PMID: 24602512. Pubmed Central PMCID: PMC3973967. Epub 2014/03/08. eng

    Google Scholar 

  57. McGowan MP, Proulx S (2009) Nutritional supplements and serum lipids: does anything work? Curr Atherosclerosis Rep 11(6):470–476. PubMed PMID: 19852889. Epub 2009/10/27. eng

    Google Scholar 

  58. Brites F, Zago V, Verona J, Muzzio ML, Wikinski R, Schreier L (2006) HDL capacity to inhibit LDL oxidation in well-trained triathletes. Life Sci 78(26):3074–3081. PubMed PMID: 16488445. Epub 2006/02/21. eng

    Google Scholar 

  59. Kloner RA, Simkhovich BZ (2005) Benefit of an exercise program before myocardial infarction. J Am Coll Cardiol 45(6):939–940. PubMed PMID: 15766832. Epub 2005/03/16. eng

    Google Scholar 

  60. Chenni A, Yahia DA, Boukortt FO, Prost J, Lacaille-Dubois MA, Bouchenak M (2007) Effect of aqueous extract of Ajuga iva supplementation on plasma lipid profile and tissue antioxidant status in rats fed a high-cholesterol diet. J Ethnopharmacol 109(2):207–213. PubMed PMID: 16949233. Epub 2006/09/05. eng

    Google Scholar 

  61. Mancini-Filho J, Van-Koiij A, Mancini DA, Cozzolino FF, Torres RP (1998) Antioxidant activity of cinnamon (Cinnamomum Zeylanicum, Breyne) extracts. Boll Chim Farm 137(11):443–447. PubMed PMID: 10077878. Epub 1999/03/17. eng

    Google Scholar 

  62. Jayaprakasha GK, Jagan Mohan Rao L, Sakariah KK (2003) Volatile constituents from Cinnamomum zeylanicum fruit stalks and their antioxidant activities. J Agric Food Chem 51(15):4344–4348. PubMed PMID: 12848508. Epub 2003/07/10. eng

    Google Scholar 

  63. Lee JS, Jeon SM, Park EM, Huh TL, Kwon OS, Lee MK et al (2003) Cinnamate supplementation enhances hepatic lipid metabolism and antioxidant defense systems in high cholesterol-fed rats. J Med Food 6(3):183–191. PubMed PMID: 14585184. Epub 2003/10/31. eng

    Google Scholar 

  64. Querfurth HW, LaFerla FM (2010) Alzheimer’s disease. N Engl J Med 362(4):329–344. PubMed PMID: 20107219. Epub 2010/01/29. eng

    Google Scholar 

  65. van Leuven F (2000) Single and multiple transgenic mice as models for Alzheimer’s disease. Prog Neurobiol 61(3):305–312. PubMed PMID: 10727777. Epub 2000/03/23. eng

    Google Scholar 

  66. Chauhan NB, Sandoval J (2007) Amelioration of early cognitive deficits by aged garlic extract in Alzheimer’s transgenic mice. Phytotherapy Res 21(7):629–640. PubMed PMID: 17380553. Epub 2007/03/24. eng

    Google Scholar 

  67. Ono K, Condron MM, Ho L, Wang J, Zhao W, Pasinetti GM et al (2008) Effects of grape seed-derived polyphenols on amyloid beta-protein self-assembly and cytotoxicity. J Biol Chem 283(47):32176–32187. PubMed PMID: 18815129. Pubmed Central PMCID: PMC2583320. Epub 2008/09/26. eng

    Google Scholar 

  68. Kim DS, Kim JY, Han YS (2007) Alzheimer’s disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1–42) insult. J Altern Complement Med 13(3):333-340. PubMed PMID: 17480132. Epub 2007/05/08. eng

    Google Scholar 

  69. George RC, Lew J, Graves DJ (2013) Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer’s disease pathogenesis. J Alzheimers Dis 36(1):21–40. PubMed PMID: 23531502. Epub 2013/03/28. eng

    Google Scholar 

  70. Frydman-Marom A, Levin A, Farfara D, Benromano T, Scherzer-Attali R, Peled S et al (2011) Orally administrated cinnamon extract reduces beta-amyloid oligomerization and corrects cognitive impairment in Alzheimer’s disease animal models. PLoS ONE 6(1):e16564. PubMed PMID: 21305046. Pubmed Central PMCID: PMC3030596. Epub 2011/02/10. eng

    Google Scholar 

  71. Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140(6):918–934. PubMed PMID: 20303880. Pubmed Central PMCID: PMC2873093. Epub 2010/03/23. eng

    Google Scholar 

  72. Ho SC, Chang KS, Chang PW (2013) Inhibition of neuroinflammation by cinnamon and its main components. Food Chem 138(4):2275–2282. PubMed PMID: 23497886. Epub 2013/03/19. eng

    Google Scholar 

  73. Tsai PJ, Tsai TH, Yu CH, Ho SC (2007) Evaluation of NO-suppressing activity of several Mediterranean culinary spices. Food Chem Toxicol Int J Published Br Ind Biol Res Assoc 45(3):440–447. PubMed PMID: 17074427. Epub 2006/11/01. eng

    Google Scholar 

  74. Quale JM, Landman D, Zaman MM, Burney S, Sathe SS (1996) In vitro activity of Cinnamomum zeylanicum against azole resistant and sensitive Candida species and a pilot study of cinnamon for oral candidiasis. Am J Chin Med 24(2):103–109. PubMed PMID: 8874667. Epub 1996/01/01. eng

    Google Scholar 

  75. Corren J, Lemay M, Lin Y, Rozga L, Randolph RK (2008) Clinical and biochemical effects of a combination botanical product (ClearGuard) for allergy: a pilot randomized double-blind placebo-controlled trial. Nutr J 7:20. PubMed PMID: 18625073. Pubmed Central PMCID: PMC2491648. Epub 2008/07/16. eng

    Google Scholar 

  76. Nagai H, Shimazawa T, Matsuura N, Koda A (1982) Immunopharmacological studies of the aqueous extract of Cinnamomum cassia (CCAq). I. Anti-allergic action. Jpn J Pharmacol 32(5):813–822. PubMed PMID: 6184511. Epub 1982/10/01. eng

    Google Scholar 

  77. Hagenlocher Y, Bergheim I, Zacheja S, Schaffer M, Bischoff SC, Lorentz A (2013) Cinnamon extract inhibits degranulation and de novo synthesis of inflammatory mediators in mast cells. Allergy 68(4):490–497. PubMed PMID: 23409834. Epub 2013/02/16. eng

    Google Scholar 

  78. Aswar UM, Kandhare AD, Mohan V, Thakurdesai PA (2015) Anti-allergic effect of intranasal administration of type-A procyanidin polyphenols based standardized extract of cinnamon bark in ovalbumin sensitized BALB/c mice. Phytotherapy Res 29(3):423–433. PubMed PMID: 25504814. Epub 2014/12/17. eng

    Google Scholar 

  79. Fillatreau S, Gray D, Anderton SM (2008) Not always the bad guys: B cells as regulators of autoimmune pathology. Nat Rev Immunol 8(5):391–397. PubMed PMID: 18437156. Epub 2008/04/26. eng

    Google Scholar 

  80. Greenwald RJ, Freeman GJ, Sharpe AH. The B7 family revisited. Annu Rev Immunol. 2005;23:515–48. PubMed PMID: 15771580. Epub 2005/03/18. eng

    Google Scholar 

  81. Kwon HK, Hwang JS, Lee CG, So JS, Sahoo A, Im CR et al (2011) Cinnamon extract suppresses experimental colitis through modulation of antigen-presenting cells. World J Gastroenterol 17(8):976–986. PubMed PMID: 21451725. Pubmed Central PMCID: PMC3057159. Epub 2011/04/01. eng

    Google Scholar 

  82. Lima FJ, Cosker F, Brito TS, Ribeiro-Filho HV, Silva CM, Aragao KS et al (2014) Antispasmodic and myorelaxant effects of the flavoring agent methyl cinnamate in gut: potential inhibition of tyrosine kinase. Eur J Pharmacol 740:192–199. PubMed PMID: 25046838. Epub 2014/07/22. eng

    Google Scholar 

  83. Esmaillzadeh A, Keshteli AH, Hajishafiee M, Feizi A, Feinle-Bisset C, Adibi P (2013) Consumption of spicy foods and the prevalence of irritable bowel syndrome. World J Gastroenterol 19(38):6465–6471. PubMed PMID: 24151366. Pubmed Central PMCID: PMC3801318. Epub 2013/10/24. eng

    Google Scholar 

  84. Kaefer CM, Milner JA (2008) The role of herbs and spices in cancer prevention. J Nutr Biochem 19(6):347–361. PubMed PMID: 18499033. Pubmed Central PMCID: PMC2771684. Epub 2008/05/24. eng

    Google Scholar 

  85. Gruenwald J, Freder J, Armbruester N (2010) Cinnamon and health. Crit Rev Food Sci Nutr 50(9):822–834. PubMed PMID: 20924865. Epub 2010/10/07. eng

    Google Scholar 

  86. Parkin DM, Bray F, Ferlay J, Pisani P (2001) Estimating the world cancer burden: Globocan 2000. Int J Cancer 94(2):153–156. PubMed PMID: 11668491. Epub 2001/10/23. eng

    Google Scholar 

  87. Crabtree JE, Covacci A, Farmery SM, Xiang Z, Tompkins DS, Perry S et al (1995) Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype. J Clin Pathol 48(1):41–45. PubMed PMID: 7706517. Pubmed Central PMCID: PMC502260. Epub 1995/01/01. eng

    Google Scholar 

  88. Zaidi SF, Muhammad JS, Shahryar S, Usmanghani K, Gilani AH, Jafri W et al (2012) Anti-inflammatory and cytoprotective effects of selected Pakistani medicinal plants in Helicobacter pylori-infected gastric epithelial cells. J Ethnopharmacol 141(1):403–410. PubMed PMID: 22433535. Epub 2012/03/22. eng

    Google Scholar 

  89. Tabak M, Armon R, Neeman I (1999) Cinnamon extracts’ inhibitory effect on Helicobacter pylori. J Ethnopharmacol 67(3):269–277. PubMed PMID: 10617061. Epub 2000/01/05. eng

    Google Scholar 

  90. Nir Y, Potasman I, Stermer E, Tabak M, Neeman I. Controlled trial of the effect of cinnamon extract on Helicobacter pylori. Helicobacter 5(2):94–97. PubMed PMID: 10849058. Epub 2000/06/10. eng

    Google Scholar 

  91. Rosti L, Gastaldi G (2005) Chronic salmonellosis and cinnamon. Pediatrics 116(4):1057. PubMed PMID: 16199729. Epub 2005/10/04. eng

    Google Scholar 

  92. Ranasinghe P, Jayawardana R, Galappaththy P, Constantine GR, de Vas Gunawardana N, Katulanda P (2012) Efficacy and safety of ‘true’ cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med J Br Diabet Assoc 29(12):1480–1492. PubMed PMID: 22671971. Epub 2012/06/08. eng

    Google Scholar 

  93. Jarvill-Taylor KJ, Anderson RA, Graves DJ (2001) A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 20(4):327–336. PubMed PMID: 11506060. Epub 2001/08/17. eng

    Google Scholar 

  94. Bandara T, Uluwaduge I, Jansz ER (2012) Bioactivity of cinnamon with special emphasis on diabetes mellitus: a review. Int J Food Sci Nutr 63(3):380–386. PubMed PMID: 22007625. Epub 2011/10/20. eng

    Google Scholar 

  95. Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth DO et al (2006) Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2. Eur J Clin Invest 36(5):340–344. PubMed PMID: 16634838. Epub 2006/04/26. eng

    Google Scholar 

  96. Suppapitiporn S, Kanpaksi N, Suppapitiporn S (2006) The effect of cinnamon cassia powder in type 2 diabetes mellitus. J Med Assoc Thailand = Chotmaihet Thangphaet 89(Suppl 3):S200–S205. PubMed PMID: 17718288. Epub 2007/08/28. eng

    Google Scholar 

  97. Vanschoonbeek K, Thomassen BJ, Senden JM, Wodzig WK, van Loon LJ (2006) Cinnamon supplementation does not improve glycemic control in postmenopausal type 2 diabetes patients. J Nutr 136(4):977–980. PubMed PMID: 16549460. Epub 2006/03/22. eng

    Google Scholar 

  98. Markey O, McClean CM, Medlow P, Davison GW, Trinick TR, Duly E et al (2011) Effect of cinnamon on gastric emptying, arterial stiffness, postprandial lipemia, glycemia, and appetite responses to high-fat breakfast. Cardiovasc Diabetol 10:78. PubMed PMID: 21899741. Pubmed Central PMCID: PMC3180260. Epub 2011/09/09. eng

    Google Scholar 

  99. Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA (2003) Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabet Care 26(12):3215–3218. PubMed PMID: 14633804. Epub 2003/11/25. eng

    Google Scholar 

  100. Roussel AM, Hininger I, Benaraba R, Ziegenfuss TN, Anderson RA (2009) Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese. J Am Coll Nutr 28(1):16–21. PubMed PMID: 19571155. Epub 2009/07/03. eng

    Google Scholar 

  101. Meades G Jr, Henken RL, Waldrop GL, Rahman MM, Gilman SD, Kamatou GP et al (2010) Constituents of cinnamon inhibit bacterial acetyl CoA carboxylase. Planta Med 76(14):1570–1575. PubMed PMID: 20379951. Epub 2010/04/10. eng

    Google Scholar 

  102. Khan A, Bryden NA, Polansky MM, Anderson RA (1990) Insulin potentiating factor and chromium content of selected foods and spices. Biol Trace Elem Res 24(3):183–188. PubMed PMID: 1702671. Epub 1990/03/01. eng

    Google Scholar 

  103. Berrio LF, Polansky MM, Anderson RA (1992) Insulin activity: stimulatory effects of cinnamon and brewer’s yeast as influenced by albumin. Horm Res 37(6):225–229. PubMed PMID: 1292975. Epub 1992/01/01. eng

    Google Scholar 

  104. Ping H, Zhang G, Ren G (2010) Antidiabetic effects of cinnamon oil in diabetic KK-Ay mice. Food Chem Toxicol Int J Published Br Ind Biol Res Assoc 48(8–9):2344–2349. PubMed PMID: 20561948. Epub 2010/06/22. eng

    Google Scholar 

  105. Qin B, Nagasaki M, Ren M, Bajotto G, Oshida Y, Sato Y (2003) Cinnamon extract (traditional herb) potentiates in vivo insulin-regulated glucose utilization via enhancing insulin signaling in rats. Diabet Res Clin Pract 62(3):139–148. PubMed PMID: 14625128. Epub 2003/11/20. eng

    Google Scholar 

  106. Couturier K, Batandier C, Awada M, Hininger-Favier I, Canini F, Anderson RA et al (2010) Cinnamon improves insulin sensitivity and alters the body composition in an animal model of the metabolic syndrome. Arch Biochem Biophys 501(1):158–161. PubMed PMID: 20515642. Epub 2010/06/03. eng

    Google Scholar 

  107. Qin B, Dawson H, Polansky MM, Anderson RA (2009) Cinnamon extract attenuates TNF-alpha-induced intestinal lipoprotein ApoB48 overproduction by regulating inflammatory, insulin, and lipoprotein pathways in enterocytes. Horm Metab Res = Hormon und Stoffwechselforschung = Hormones et metabolisme 41(7):516–522. PubMed PMID: 19593846. Epub 2009/07/14. eng

    Google Scholar 

  108. Qin B, Polansky MM, Sato Y, Adeli K, Anderson RA (2006) Cinnamon extract inhibits the postprandial overproduction of apolipoprotein B48-containing lipoproteins in fructose-fed animals. J Nutr Biochem 20(11):901–908. PubMed PMID: 18993048. Epub 2008/11/11. eng

    Google Scholar 

  109. Hong CH, Hur SK, Oh OJ, Kim SS, Nam KA, Lee SK (2002) Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol 83(1–2):153–159. PubMed PMID: 12413723. Epub 2002/11/05. eng

    Google Scholar 

  110. Oussalah M, Caillet S, Lacroix M (2006) Mechanism of action of Spanish oregano, Chinese cinnamon, and savory essential oils against cell membranes and walls of Escherichia coli O157:H7 and Listeria monocytogenes. J Food Prot 69(5):1046–1055. PubMed PMID: 16715803. Epub 2006/05/24. eng

    Google Scholar 

  111. Premanathan M, Rajendran S, Ramanathan T, Kathiresan K, Nakashima H, Yamamoto N (2000) A survey of some Indian medicinal plants for anti-human immunodeficiency virus (HIV) activity. Indian J Med Res 112:73–77. PubMed PMID: 11094851. Epub 2000/11/30. eng

    Google Scholar 

  112. Dudonne S, Vitrac X, Coutiere P, Woillez M, Merillon JM (2009) Comparative study of antioxidant properties and total phenolic content of 30 plant extracts of industrial interest using DPPH, ABTS, FRAP, SOD, and ORAC assays. J Agric Food Chem 57(5):1768–1674. PubMed PMID: 19199445. Epub 2009/02/10. eng

    Google Scholar 

  113. Kitazuru ER, Moreirac AVA, Mancini-Filhoc J, Delincee H, Villavicencioa ALCH (2004) Effects of irradiation on natural antioxidants of cinnamon (Cinnamomum zeylanicum N.). Radiat Phys Chem 71(1–2):37–49. Epub 2004/04/14. eng

    Google Scholar 

  114. Sharma V, Rao LJ (2014) An overview on chemical composition, bioactivity and processing of leaves of Cinnamomum tamala. Crit Rev Food Sci Nutr 54(4):433–448. PubMed PMID: 24236996. Epub 2013/11/19. eng

    Google Scholar 

  115. Ranasinghe P, Pigera S, Premakumara GA, Galappaththy P, Constantine GR, Katulanda P (2013) Medicinal properties of ‘true’ cinnamon (Cinnamomum zeylanicum): a systematic review. BMC Complement Altern Med 13:275. PubMed PMID: 24148965. Pubmed Central PMCID: PMC3854496. Epub 2013/10/24. eng

    Google Scholar 

  116. Lin LT, Wu SJ, Lin CC (2013) The anticancer properties and apoptosis-inducing mechanisms of cinnamaldehyde and the herbal prescription Huang-Lian-Jie-Du-Tang (Huang Lian Jie Du Tang) in human hepatoma cells. J Tradit Complement Med 3(4):227–233. PubMed PMID: 24716182. Pubmed Central PMCID: PMC3924998. Epub 2014/04/10. eng

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Reza Ghiasvand .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Hariri, M., Ghiasvand, R. (2016). Cinnamon and Chronic Diseases. In: Gupta, S., Prasad, S., Aggarwal, B. (eds) Drug Discovery from Mother Nature. Advances in Experimental Medicine and Biology, vol 929. Springer, Cham. https://doi.org/10.1007/978-3-319-41342-6_1

Download citation

Publish with us

Policies and ethics