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Proteases in Melanoma

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Book cover Melanoma Development

Abstract

Several proteolytic enzymes, produced by the tumor cells themselves or by the “tumor-activated” stroma, have been implicated in the pathogenesis of cancer including melanoma. From the formation of a primary tumor to the invasion of the underlying connective tissue, as a prerequisite for metastasis a series of proteolytic events are necessary to modify not only the pericellular environment but also host-tumor communication. We shortly review the most important and characterized proteolytic enzymes, their degradative activities, and the impact that those events have on the progression of tumor cells through tissues. We will especially concentrate on those enzymes participating in cellular communication, cell adhesion and matrix remodeling.

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Acknowledgments

This work was supported by the Deutsche Forschungsgemeinschaft through the SFB829 and by the Melanoma Research Network of the Deutsche Krebshilfe (Melanoma Verbund).

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  1. Department of Dermatology, University of Cologne, Kerpener Strasse 62, 50937, Cologne, Germany

    Paola Zigrino & Cornelia Mauch

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  1. Paola Zigrino
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  2. Cornelia Mauch
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Correspondence to Paola Zigrino .

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  1. Institute for Biochemistry, Erlangen, Germany

    Anja K. Bosserhoff

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Zigrino, P., Mauch, C. (2017). Proteases in Melanoma. In: Bosserhoff, A. (eds) Melanoma Development. Springer, Cham. https://doi.org/10.1007/978-3-319-41319-8_8

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