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Genetic and Epigenetic Testing in Integrative Dermatology

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Personalized, Evolutionary, and Ecological Dermatology

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Abstract

The human genome consists of about 100,000 genes, of which approximately 20,000 code for structural peptides and proteins. Most of the remainder are control genes similar to off-on switches or other regulatory mechanisms. Epigenetics involves regulation of gene activation and deactivation through DNA methylation, alterations in histone structure, microRNA activity, and other factors. Genetic skin disorders, inflammatory and immune responses, and benign and malignant tumors all have genetic and epigenetic aspects. Understanding these genetic and epigenetic influences can assist in integrative management of common skin disorders as discussed in this chapter.

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Authors and Affiliations

  1. Department of Dermatology and Cutaneous Surgery, University of South Florida, 12901 Bruce B. Downs Blvd, Tampa, FL, 33612, USA

    Philip D. Shenefelt MD

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  1. Philip D. Shenefelt MD
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Correspondence to Philip D. Shenefelt MD .

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Editors and Affiliations

  1. Department of Dermatology , Nova Southeastern Medical School, Ft. Lauderdale, Florida, USA

    Robert A. Norman

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Shenefelt, P.D. (2016). Genetic and Epigenetic Testing in Integrative Dermatology. In: Norman, R. (eds) Personalized, Evolutionary, and Ecological Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-319-41088-3_2

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  • DOI: https://doi.org/10.1007/978-3-319-41088-3_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-41086-9

  • Online ISBN: 978-3-319-41088-3

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